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| 1 | Functional-trait ecology of the plateau pika Ochotona curzoniae in the Qinghai-Tibetan Plateau ecosystem显示文摘Understanding a species’functional traits allows for a directed and productive perspective on the role a species plays in nature,and thus its relative importance to conservation planning.The functionaltrait ecology of the plateau pika Ochotona curzoniae is examined to better understand the resilience and sustainability of the high alpine grasslands of the Qinghai-Tibetan Plateau(QTP).The key functional traits of plateau pikas are their abundance and behavior of digging extensive burrow systems.Plateau pikas have been poisoned over a significant part of their original geographic distribution across the QTP,allowing comparison of ecological communities with and without pikas.Nearly all mammalian and avian carnivores,most of which are obligate predators on pikas,have been lost in regions where pikas have been poisoned.Most endemic birds on the QTP nest in pika burrows;when pikas are poisoned,burrows collapse,and these birds are greatly reduced in number.Due to the biopedturbation resulting from their burrows,regional plant species richness is higher in areas with pikas than without.The presence of pika burrows allows higher rates of infiltration during heavy monsoon rains compared to poisoned areas,possibly mitigating runoff and the potential for serious downslope erosion and flooding.Thus,the functional traits of plateau pikas enhance native biodiversity and other important ecosystem functions;these traits are irreplaceable.As plateau pikas are not natural colonizers,active reintroduction programs are needed to restore pikas to areas from which they have been poisoned to restore the important functional ecological traits of pikas. | Andrew T.SMITH BADINGQIUYING Maxwell C.WILSON Brigitte W.HOGAN | 2019 | Integrative Zoology2019，14，1： | 3 |
| 2 | Genome‐wide methylation profiling in Crohn’s disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway显示文摘 | Elaine R.Nimmo James G.Prendergast Marian C.Aldhous Nicholas A.Kennedy PaulHenderson Hazel E.Drummond Bernard H.Ramsahoye David C.Wilson Colin A.Semple JackSatsangi | 2012 | Inflamm Bowel Dis2012，，： | 2 |
| 3 | Anvil glaciation in a deep cumulus updraught over Florida simulated with the Explicit Microphysics Model. I: Impact of various nucleation processes显示文摘 | Vaughan T. J.Phillips ConstantinAndronache Steven C.Sherwood AaronBansemer William C.Conant Paul J.Demott Richard C.Flagan AndyHeymsfield HaflidiJonsson MichealPoellot Tracey A.Rissman John H.Seinfeld TimVanreken VaruntidaVarutbangkul James C.Wilson | 2006 | 2006 (609)2006，，609： | 1 |
| 4 | Come and Take a Walk:Listening to Early Head Start Parents on School-Readiness as a Matter of Child,Family, and Community Health显示文摘 | Carol L.McAllister Patrick C.Wilson Beth L.Green Jennifer L.Baldwin | | 0，，04： | 1 |
| 5 | The monocarboxylate transporter family—Role and regulation显示文摘 | Andrew P.Halestrap Marieangela C.Wilson | 2012 | IUBMB Life2012，，2： | 1 |
| 6 | The Paradox of Social Class and Sports Involvement; The Role of Cultural and Economic Capital显示文摘 | Thomas C.Wilson | | 0，，01： | 1 |
| 7 | Numerical and experimental investigation on aluminum 6061-Vgrooved stainless steel 304 explosive cladding显示文摘This study attempts to analyze the microstructure and interface behavior of aluminum 6061(Al 6061)-Vgrooved stainless steel(SS304)explosive cladding by numerical and experimental methods.Numerical simulation was performed by Smoothed Particle Hydrodynamics(SPH)technique,in ANSYS AUTODYN,and the results are correlated with experimental outcome.The machining of V-grooves on the base plate transform the melted layer formed in conventional cladding(without grooves on the base plate)into a smooth undulating interface,for a similar experimental condition.The flyer plate and collision velocities,observed in numerical simulation,are in good agreement to the analytical expectations.The pressure developed in the flyer plate is higher than the base plate and the maximum pressure is witnessed at the collision point irrespective of grooved base plate or otherwise.The temperature developed in the collision point of conventional explosive cladding exceeds the melting point of both the participant metals,whereas,it exceeds the melting point of aluminum alone,in case of V-grooved base plate cladding.The shear and impact strengths of the V-grooved base plate clads are higher than the conventional clads and the fracture surfaces exhibit mixed modes of fracture. | C.Wilson dhileep kumar S.Saravanan K.Raghukandan | 2022 | Defence Technology(防务技术)2022，18，2： | 1 |
| 8 | Long‐term results of a randomized trial comparing holmium laser enucleation of the prostate and transurethral resection of the prostate: results at 7 years显示文摘 | Peter J.Gilling Liam C.Wilson Colleen J.King Andre M.Westenberg Christopher M.Frampton Mark R.Fraundorfer | 2012 | BJU International2012，，3： | 1 |
| 9 | Changes and Reforms in Public Administration Education显示文摘 | Thomas Voicina Linda C.Wilson | | 0，，： | 1 |
| 10 | Long‐term results of a randomized trial comparing holmium laser enucleation of the prostate and transurethral resection of the prostate: results at 7 years显示文摘 | Peter J.Gilling Liam C.Wilson Colleen J.King Andre M.Westenberg Christopher M.Frampton Mark R.Fraundorfer | 2012 | BJU International2012，，3： | 1 |
| 11 | 加利福尼亚小狼湖地震引起的边坡崩塌的动力学分析显示文摘引 言 纽马克(Newmark)(1965)提出的动力边坡稳定性分析的方法正在不断地用于地震区的土坝工程设计、公路渠道和其它人造坡。这种分析此处称为“纽马克分析”,它结合了两种资料:(1)临界加速度,在这种加速度情况下,边坡可达到其最大强度的地面加速度值;2)强震地震图,它记录了地面加速度的对应时间。纽马克分析根据强震图应用与边坡主题有关的加速度历史原始材料中相同的临界加速度计算出刚性摩擦块体的位移。因此,边坡工程的设计必须两者择一:(1)很牢固,足以屈服在预计地震发生的过程中出现的仅有的小位移。(2)很柔韧,足以承受一个较大的位移。所以,纽马克分析给设计人员提供了当第一种方法不可行时,可选择第二种方法的自由。 | RAYMOND C.WILSON DAVID K.KEEFER 李时若 | 1984 | 地质科技情报1984，7，1： | 1 |
| 12 | Systematic review: medical and nutritional interventions for the management of intestinal failure and its resultant complications in children显示文摘 | A. R.Barclay L. M.Beattie L. T.Weaver D. C.Wilson | 2010 | Alimentary Pharmacology & Therapeutics2010，，2： | 1 |
| 13 | Genetics of the innate immune response in inflammatory bowel disease显示文摘 | JohanVan Limbergen Richard K.Russell Elaine R.Nimmo Gwo‐TzerHo Ian D.Arnott David C.Wilson JackSatsangi | 2007 | Inflamm Bowel Dis2007，，3： | 1 |
| 14 | IN VIVO NEAR-INFRAREDFLUORESCENCEIMAGING OF HUMANCOLONADENOCARCINOMABY SPECIFIC IMMUNOTARGETINGOFA TUMOR-ASSOCIATEDMUCIN显示文摘Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. Methods: The fluorescent anti-TAG72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled CC49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-CC49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of CC49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. Conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy. | RALPH S.DACOSTA YING TANG TUULA KALLIOMAKI RAYMOND M.REILLY ROBERT WEERSINK ALISHA R.ELFORD NORMAN E.MARCON BRIAN C.WILSON | 2009 | Journal of Innovative Optical Health Sciences2009，2，4： | 0 |
| 15 | A portable X-pinch design for x-ray diagnostics of warm dense matter显示文摘We describe the design and x-ray emission properties(temporal,spatial,and spectral)of Dry Pinch I,a portable X-pinch driver developed at Imperial College London.Dry Pinch I is a direct capacitor discharge device,30033003700 mm3 in size and∼50 kg in mass,that can be used as an external driver for x-ray diagnostics in high-energy-density physics experiments.Among key findings,the device is shown to reliably produce 1.1±0.3 ns long x-ray bursts that couple∼50 mJ of energy into photon energies from 1 to 10 keV.The average shot-to-shot jitter of these bursts is found to be 10±4.6 ns using a combination of x-ray and current diagnostics.The spatial extent of the x-ray hot spot from which the radiation emanates agrees with previously published results for X-pinches-suggesting a spot size of 10±6μm in the soft energy region(1–10 keV)and 190±100μm in the hard energy region(>10 keV).These characteristics mean that Dry Pinch I is ideally suited for use as a probe in experiments driven in the laboratory or at external facilities when more conventional sources of probing radiation are not available.At the same time,this is also the first detailed investigation of an X-pinch operating reliably at current rise rates of less than 1 kA/ns. | J.Strucka J.W.D.Halliday T.Gheorghiu H.Horton B.Krawczyk P.Moloney S.Parker G.Rowland N.Schwartz S.Stanislaus S.Theocharous C.Wilson Z.Zhao T.A.Shelkovenko S.A.Pikuz S.N.Bland | 2022 | Matter and Radiation at Extremes2022，7，1： | 0 |
| 16 | The diagnostic and prognostic utility of the dual-task tandem gait test for pediatric concussion显示文摘Background:The tandem gait test has gained interest recently for assessment of concussion recovery.The purpose of our study was to determine the prognostic and diagnostic use of the single-and dual-task tandem gait test,alongside other clinical measures,within 10 days of pediatric concussion.Methods:We assessed 126 patients post-concussion(6.3§2.3 days post-injury,mean§SD)at a pediatric sports medicine clinic and compared them to 58 healthy controls(age:15.6§1.3 years;43%female).We also compared the 31 patients with concussion who developed persistent post-concussion symptoms(PPCS)(age=14.9§2.0 years;48%female)to the 81 patients with concussion who did not develop PPCS following the initial assessment(age:14.1§3.0 years;41%female).All subjects completed a test battery,and concussion patients were monitored until they experienced concussion-symptom resolution.The test battery included tandem gait(single-task,dual-task(performing tandem gait while concurrently completing a cognitive test)conditions),modified Balance Error Scoring System(mBESS),and concussion symptom assessment(Health and Behavior Inventory).We defined PPCS as symptom resolution time>28 days post-concussion for the concussion group.Measurement outcomes included tandem gait time(single-and dual-task),dual-task cognitive accuracy,mBESS errors(single/double/tandem stances),and symptom severity.Results:The concussion group completed the single-task(mean difference=9.1 s,95%confidential interval(95%CI):6.1-12.1)and dual-task(mean difference=12.7 s,95%CI:8.716.8)tandem gait test more slowly than the control group.Compared to those who recovered within 28 days of concussion,the PPCS group had slower dual-task tandem gait test times(mean difference=7.9 s,95%CI:2.0-13.9),made more tandem-stance mBESS errors(mean difference=1.3 errors,95%CI:0.2-2.3),and reported more severe symptoms(mean difference=26.6 Health and Behavior Inventory rating,95%CI:21.1-32.6).Conclusion:Worse dual-task tandem gait test time and mBESS tandem stance performance predicted PPCS in pediatric patients evaluated within 10 days of concussion.Tandem gait assessments may provide valuable information augmenting common clinical practices for concussion management. | Katie A.Van Deventer Corrine N.Seehusen Gregory A.Walker Julie C.Wilson David R.Howell | 2021 | Journal of Sport and Health Science2021，10，2： | 0 |
| 17 | SINGLET OXYGEN DETECTION DURING PHOTOSENSITIZATION显示文摘Singlet oxygen(^(1)O_(2))is a highly reactive oxygen species involved in numerous chemical and photochemical reactions in diferent biological systems and in particular,in photodynamic therapy(PDT).However,the quantifcation of^(1)O_(2) generation during in vitro and in vivo pho-tosensitization is still technically challenging.To address this problem,indirect and direct methods for^(1)O_(2)detection have been intensively studied.This review presents the available methods currently in use or under development for detecting and quantifying^(1)O_(2) generation during photosensitization.The advantages and limitations of each method will be presented.Moreover,the future trends in developing PDT-^(1)O_(2) dosimetry will be briefly discussed. | BUHONG LI HUIYUN LIN DEFU CHEN BRIAN C.WILSON YING GU | 2013 | Journal of Innovative Optical Health Sciences2013，6，1： | 0 |
| 18 | Editorial-Introduction to the Special Issue on Photodynamic Therapy显示文摘Photodynamic therapy(PDT)is a minimally invasive treatment for malignant and nonmalignant diseases that uses light-activated photosensitizers to destroy or modify cells or tissues.It has been approved by health agencies in several countries for cancers of different sites and stages,and for treatment of age related macular degeneration,various benign skin conditions and localized bacterial infections. | Buhong Li Brian C.Wilson | 2015 | Journal of Innovative Optical Health Sciences2015，8，1： | 0 |
| 19 | Correlation of in vivo tumor response and singlet oxygen luminescence detection in mTHPC-mediated photodynamic therapy显示文摘Excited-state singlet axygen(^(1)O_(2)),generated during photodynamic therapy(PDT),is believed to be the primary cytotoxic agent with a number of clinically approved photosensitizers.Its relative concentration in cells or tissues can be measured directly through its near-infrared(NIR)luminescence emission,which has correlated well with in vitro cell and in triro normal skin treatment responses.Here,its correlation with the response of tumor tiss1e in vito is examined,using the photosensitizer meso-tetralydroxyphenylchlorin(mTHPC)in an animal model comprising luciferase-and green fluorescent protein(GFP)-transduced gliosarcoma grown in a dorsal window chamber.The change in the bioluminescence signal,imaged pre-treatment and at 2,5 and 9 d post treatment,was used as a quantitative measure of the tumor response,which was classified in individual tumors as'non','moderate'and'strong'in order to reduce the variance in the data.Plotting the bioluminescence-based response vs the^(1)O_(2)counts demonstrated clear correlation,indicating tha^(1)O_(2)luminescence provides a valid do-simetric technique for PDT in tumor tissue. | Brian C.Wilson Michael S.Patterson Buhong Li Mark T.Jarvi | 2015 | Journal of Innovative Optical Health Sciences2015，8，1： | 0 |
| 20 | Effects of Preheat on the Thermodynamics of the ICF Hot Spot显示文摘 | Jeremy Melvin Hyunkyung Lim Verinder Rana Baolian Cheng James Glimm David H. Sharp Doug C.Wilson | 2015 | Journal of Physical Science and Application2015，5，1： | 0 |
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