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| 1 | Gastrointestinal symptoms in Chinese patients with Type 2 diabetes mellitus显示文摘 | G. T. C.Ko W. ‐B.Chan J. C. N.Chan L. W. W.Tsang C. S.Cockram | 2001 | Diabetic Medicine2001，，8： | 1 |
| 2 | Effects of PEEP levels following repeated recruitment maneuvers on ventilator‐induced lung injury显示文摘 | S.‐C.KO H.ZHANG J. J.HAITSMA K.‐C.CHENG C.‐F.LI A. S.SLUTSKY | 2008 | Acta Anaesthesiologica Scandinavica2008，，4： | 1 |
| 3 | Clinical implications of hypermucoviscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community‐acquired bacteraemia显示文摘 | H.‐C.LEE Y.‐C.CHUANG W.‐L.YU N.‐Y.LEE C.‐M.CHANG N.‐Y.KO L.‐R.WANG W.‐C.KO | 2006 | Journal of Internal Medicine2006，，6： | 1 |
| 4 | Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis显示文摘Chronic pancreatitis(CP)is a major risk factor of pancreatic ductal adenocarcinoma(PDAC).How CP promotes pancreatic oncogenesis remains unclear.A characteristic feature of PDAC is its prominent desmoplasia in the tumor microenvironment,composed of activated fibroblasts and macrophages.Macrophages can be characterized as M1 or M2,with tumor-inhibiting or-promoting functions,respectively.We reported that Gremlin 1(GREM1),a key pro-fibrogenic factor,is upregulated in the stroma of CP.The current study aimed to investigate the expression of GREM1 and correlation between GREM1 and macrophages within the pancreas during chronic inflammation and the development of PDAC.By mRNA in situ hybridization,we detected GREM1 mRNA expression withinα-smooth muscle actin(SMA)-positive fibroblasts of the pancreatic stroma.These designated FibroblastsGrem1+marginally increased from CP to pancreatic intraepithelial neoplasia(PanIN)and PDAC.Within PDAC,FibroblastsGrem1+increased with higher pathological tumor stages and in a majority of PDAC subtypes screened.Additionally,FibroblastsGrem1+positively correlated with total macrophages(MacCD68+)and M2 macrophages(M2CD163+)in PDAC.To begin exploring potential molecular links between FibroblastsGrem1+and macrophages in PDAC,we examined the expression of macrophage migration inhibitory factor(MIF),an endogenous counteracting molecule of GREM1 and an M1 macrophage promoting factor.By IHC staining of MIF,we found MIF to be expressed by tumor cells,positively correlated with GREM1;by IHC co-staining,we found MIF to be negatively correlated with M2CD163+expression.Our findings suggest that GREM1 expression by activated fibroblasts may promote PDAC development,and GREM1/MIF may play an important role in macrophage phenotype. | Joy M.Davis Binglu Cheng Madeline M.Drake Qiang Yu Baibing Yang Jing Li Chunhui Liu Mamoun Younes Xiurong Zhao Jennifer M.Bailey Qiang Shen Tien C.Ko Yanna Cao | 2022 | Genes & Diseases2022，9，1： | 0 |
| 5 | 龈瓣推进术中双瓣切口和骨膜松弛切口的比较显示文摘目的:本研究旨在评价垂直向牙槽骨增量时两种牙周松弛切口的效能及相关临床事件发生情况。材料和方法:选取23例垂直和水平骨缺损的患者(Seibert分类Ⅲ)对双瓣切口(double-flap incision,DFI)和传统骨膜松弛切口(periosteal releasing incision,PRI)进行比较,随机采用一种切口进行龈瓣推进.测量龈瓣推进的量、术后并发症的发生率,并比较患者不适的程度。采用UNC-15探针测量最初翻起的龈瓣和推进后的龈瓣,两者的差记为龈瓣推进量;术后并发症包括早期膜暴露、感染、感觉异常和随访中发现持续不适;采用视觉模拟量表(visual analog scale,VAS)量化患者疼痛、肿胀和出血的程度。结果:DFI组的平均龈瓣推进为9.64±0.92mm.而PRI组的平均龈瓣推进为7.13±1.45mm(P〈0.001);早期膜暴露PRI组发生2例,DFI组发生1例:感觉异常、感染和术后并发症的发生率(PRI.5;DFI,1).没有明显统计学差异(P〈0.082);DFI组的平均疼痛、肿胀和出血计分(分别为1.55±1.21,1.91±0.94,0.40±0.12)比PRI组(分别为3.75±2.63,3.25±1.29,1.16±0.34)低(分别为P=0.019,P=0.010.P=0.061)。结论:DFI组有助于龈瓣推进并且减少相关临床事件的发生,此技术有可能成为龈瓣推进的另一选择,能够克服PRI的一些局限性。 | Yumi Ogata Terrence J.Griffin Alexander C.Ko Yong Hur 林潇 李钧 | 2015 | 中国口腔医学继续教育杂志2015，0，5： | 0 |
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