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| 1 | Advances in nutritional therapy in inflammatory boweldiseases:Review显示文摘Inflammatory bowel diseases(IBD), including ulcerative colitis and Crohn's disease are chronic, life-long, and relapsing diseases of the gastrointestinal tract. Currently, there are no complete cure possibilities, but combined pharmacological and nutritional therapy may induce remission of the disease. Malnutrition and specific nutritional deficiencies are frequent among IBD patients, so the majority of them need nutritional treatment, which not only improves the state of nutrition of the patients but has strong anti-inflammatory activity as well. Moreover, some nutrients, from early stages of life are suspected as triggering factors in the etiopathogenesis of IBD. Both parenteral and enteral nutrition is used in IBD therapy, but their practical utility in different populations and in different countries is not clearly established, and there are sometimes conflicting theories concerning the role of nutrition in IBD. This review presents the actual data from research studies on the influence of nutrition on the etiopathogenesis of IBD and the latest findings regarding its mechanisms of action. The use of both parenteral and enteral nutrition as therapeutic methods in induction and maintenance therapy in IBD treatment is also extensively discussed. Comparison of the latest research data, scientific theories concerning the role of nutrition in IBD, and different opinions about them are also presented and discussed. Additionally, some potential future perspectives for nutritional therapy are highlighted. | Andrzej Wędrychowicz Andrzej Zając Przemysław Tomasik | 2016 | World Journal of Gastroenterology2016，22，3： | 21 |
| 2 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 3 | Korean pine nut fatty acids affect appetite sensations,plasma CCK and GLP 1 in overweight subjects 显示文摘 | Einerhand AW Pasman W Rubingh C | 2006 | FASEB J2006，20，： | 1 |
| 4 | Comparision of ISCCP and other cloud amounts显示文摘 | Rossow W B Walker AW Garder L C | 1993 | J Climate1993，6，： | 1 |
| 5 | Genetic enhancenentof fracture repair, healing of an experimental sepmental defect by adenoviral transfer of the BMP-2 gene显示文摘 | Bahzer Aw Lattermann C W halen JD el al | 2000 | Gene Ther2000，7，9： | 1 |
| 6 | Evaluation of climatic vibration testing on plastic waterproof enclosure for elec- tronic equipment using ANSYS (R) workbench 显示文摘 | AW K C HUANG W D J DE Silva | 2007 | Ma- ter Design2007，28，9： | 1 |
| 7 | Genetic enhancement of fracture repair:healing of an experimental segmental defect by adenoviral transfer of the bmp-2 gene 显示文摘 | Baltzer AW Lattermann C W halen JD | 2000 | Gene Ther2000，7，6： | 1 |
| 8 | Synthetic lethal screen identification of chemosensitizer loci in cancer ceils显示文摘 | Bodemann BO Cardenas J Ferguson D Girard L Peyton M Minna JD Michnoff C Hao W Roth MG Xie XJ White MA | 2007 | Nature2007，446，： | 1 |
| 9 | Insulin-like growth factor I receptor primary structure:comparison with insulin receptor suggests structural determinants that define functional specificity显示文摘 | Ullrich A Gray A Tam AW Yang-Feng T Tsubokawa M Collins C Henzel W Le Bon T Kathuria S Chen E | | 0，，： | 1 |
| 10 | Study of degradation mechanism of blue-light emitting diodes 显示文摘 | A Uddin C W Aw T G Andersson | 2005 | Thin Solid Films2005，483，12： | 1 |
| 11 | Evaluation of climatic vibration testing on plastic waterproof enclosure for electronic equipment using ANSYS workbench显示文摘 | Aw K C Huang W D J De Silva M W R P | 2007 | Materials and Design2007，28，： | 1 |
| 12 | The genus Rhodococcus显示文摘 | Bell K S Philp J C Aw D W J | 1998 | Journal of Applied Microbiology1998，85，： | 1 |
| 13 | Beneficial effects of soluble dietary Jerusalem artichoke(Helianthus tuberosus)in the prevention of the onset of type 2 diabetes and nonalcoholic fatty liver disease in high-fructose diet-fed rats显示文摘 | Chang W C Jia H J Aw W P | 2014 | British Journal of Nutrition2014，112，5： | 1 |
| 14 | Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6 显示文摘 | Langermans JA Doherty TM Vervenne RA van der Laan T Lyashchenko K Greenwald R Agger EM Aagaard C Weiler H van Soolingen D Dalemans W Thomas AW Andersen P | 2005 | Vaccine2005，23，21： | 1 |
| 15 | Comparison of PCR-DGGE and Nested-PCR-DGGE approach for ammonia oxidizers monitoring in membrane bioreactors’activated sludge显示文摘 | Aleksandra Z B Jaros aw W S awomir C | 2014 | Archives of Environmental Protection2014，40，4： | 1 |
| 16 | Multiplex neuritis in a patient with autoimmune hepatitis:A case report显示文摘A 37-year old woman presented with a 9-year history of hepatitis of unknown origin and aminotransferases within a 3-fold upper limit of normal. Autoimmune hepatitis (AIH) was diagnosed on the basis of elevated aminotransferases, soluble liver antigen/liver pancreas (SLA/LP) autoantibodies and characteristic histology. Immunosuppressive therapy led to rapid normalization of aminotransferases. Two years later, the patient developed left sided hemisensory deficits under maintenance therapy of prednisolone and azathioprine (AZT). Later she developed right foot drop and paraesthesia in the ulnar innervation territory on both sides. Magnetic resonance imaging (MRI) and cerebral panangiography suggested cerebral vasculitis. Neurological investigation and electromyography disclosed multiplex neuritis (MN) probably due to vasculitis. Consistent with this diagnosis, autoantibodies to extractable nuclear antigens were detectable in serum. Immunosuppression was changed to oral 150 mg cyclophosphamide (CPM0) per day. Prednisolone was increased to 40 mg/d and then gradually tapered to 5 mg. Oral CPM was administered up to a total dose of 40 g and then substituted by 6 times of an intervall infusion therapy of CPM (600 mg/m2). Almost complete motoric remission was achieved after 3 mo of CPM. Sensibility remained reduced in the right peroneal innervation territory. Follow-up of cranial MRI provided stable fi ndings without any new or progressive lesions. This is the fi rst report of multiplex neuritis in a patient with autoimmune hepatitis. | S Lüth F Birklein C Schramm J Herkel E Hennes W Müller-Forell PR Galle AW Lohse | 2006 | World Journal of Gastroenterology2006，12，33： | 0 |
| 17 | Peptides from adipose tissue in mental disorders显示文摘Adipose tissue is a dynamic endocrine organ that is essential to regulation of metabolism in humans. A new approach to mental disorders led to research oninvolvement of adipokines in the etiology of mental disorders and mood states and their impact on the health status of psychiatric patients, as well as the effects of treatment for mental health disorders on plasma levels of adipokines. There is evidence that disturbances in adipokine secretion are important in the pathogenesis, clinical presentation and outcome of mental disorders. Admittedly leptin and adiponectin are involved in pathophysiology of depression. A lot of disturbances in secretion and plasma levels of adipokines are observed in eating disorders with a significant impact on the symptoms and course of a disease. It is still a question whether observed dysregulation of adipokines secretion are primary or secondary. Moreover findings in this area are somewhat inconsistent, owing to differences in patient age, sex, socioeconomic status, smoking habits, level of physical activity, eating pathology, general health or medication. This was the rationale for our detailed investigation into the role of the endocrine functions of adipose tissue in mental disorders. It seems that we are continually at the beginning of understanding of the relation between adipose tissue and mental disorders. | Andrzej W?drychowicz Andrzej Zaj?c Maciej Pilecki Barbara Ko?cielniak Przemys?aw J Tomasik | 2014 | World Journal of Psychiatry2014，4，4： | 0 |
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