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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Frequency selectivity, multistability, and oscillations emerge from models ofgenetic regulatory systems显示文摘 | SMOLEN P BAXTER D A BYRNE J H | 1998 | Amer J Phys1998，274，： | 1 |
| 3 | Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate显示文摘 | Zhou P Byrne C Jacobs J | 1995 | Genes Dev1995，9，： | 1 |
| 4 | Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)显示文摘 | Byrne J A Mattie M G Basset P | 1996 | Genomics1996，35，3： | 1 |
| 5 | Urinary pro- teases degrade albumin: implications for measurement of albuminuria in stored samples 显示文摘 | Kania K Byrnes EA Beilby J P | 2010 | Ann Clin Bio- chem2010，47，2： | 1 |
| 6 | Systemic disease involving an iridovirus-like agent in cultured tilapia,Oreochromis niloticus显示文摘 | McGrogan D G Ostland V E Byrne P J | 1998 | Journal of Fish Diseases1998，21，2： | 1 |
| 7 | Conditionals:A Theory of Meaning,Pragmatics,and Inference显示文摘 | BYRNE M J | 2002 | PsychologicalReview2002，109，4： | 1 |
| 8 | Superiority of anti-re-flux stent compared with conventional stents in the palliativemanagement of patients with cancer of the lower esophagusand esophagogastric junction:results of a randomized clinicaltrial显示文摘 | Power C Byrne P J Lim K | 2007 | Dis Esophagus2007，20，6： | 1 |
| 9 | The plasma cascade and matrix metalloproteinases in non-small cell lung cancer显示文摘 | G Cox W P Staward K J O'Byrne | 1999 | Thorax1999，54，1： | 1 |
| 10 | Examination of behavioral deficits triggered by targeting BDNF in fetal or postnatal brains of mice显示文摘 | Chan J P Unger T J Byrnes J Rios M | 2006 | Neuroscience2006，142，： | 1 |
| 11 | Characterization of the Mississippian chat in south-central Kansas显示文摘 | Watney W L Guy W J Byrnes A P | 2001 | AAPG Bulletin2001，85，1： | 1 |
| 12 | Sc(BINOL)Li: A new heterobimetallic catalyst for the asymmetric Strecker reaction显示文摘 | Chavarot M Byrne J J Chavant P Y | 2001 | Tetrahedron: Asymmetry2001，12，： | 1 |
| 13 | Importance of Airway Inflammation for Hyperresponsiveness Induced by Ozone显示文摘 | HOLTZMAN M J FABBRI L M O'BYRNE P M | 2003 | Am Rev Respir Dis2003，127，： | 1 |
| 14 | Water treatment using nano-crystalline TiO2 electrodes 显示文摘 | J A Byrne A Davidson P S M Dunlop | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，： | 1 |
| 15 | Endoscopic transthoracic electrocautery of the sympathetic chain for palmar and axillary hyperhidrosis显示文摘 | Byrne J Walsh T N Hederman W P | 1990 | Br J Surg1990，77，9： | 1 |
| 16 | Cholecystectomy and gas- tro-esophageal reflux显示文摘 | Walson T N Jazrawi S Byrne P J et aI | 1991 | Br J Surg1991，78，： | 1 |
| 17 | Development in the measurements of air- filled porosity of peat substrates 显示文摘 | Byrne P J Carty B | 1989 | Acta Horticulture1989，366，： | 1 |
| 18 | Prevention of the neo- plastic progression of Btt' s esophagus by endoscopic argon beamplasma ablation显示文摘 | Morris C I) Byrne J P Armstiong G R | 2001 | Br J Surg2001，88，10： | 1 |
| 19 | Campath-1G causes rapid depletion of circulating host dendritic cells(DCs) before allogeneic transplantation but does not delay donor DC reconstitution显示文摘 | Klangsinsirikul P Carter G I Byrne J L | 2002 | Blood2002，99，： | 1 |
| 20 | The Photocatalytic Removal of Bacterial Pollutants from Drinking Water显示文摘 | Dunlop P S M Byrne J A Manga N et 81 | 2002 | Journal of Photochemistry and Photobiology A-Chemistry2002，148，： | 1 |
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