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| 1 | Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa显示文摘Autophagy is invoIved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged organelles.Cryptorchidism is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in ejaculates.The aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid patients.Semen samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron microscopy.Autophagy protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm cells.LC3 was also detected in the midpiece of cryptorchid sperm tail.Autophagy substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid ones.Transmission electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid samples.Partly degraded mitochondria were frequently discerned in autophagic vacuoles.In conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to control.Our work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological conditions.Thus,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men. | Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 2 | Effects of rapeseed meal-glucosinolates on thyroid metabolism and feed utilization in rainbow trout显示文摘 | Burel C | 2001 | General and Comparative Endocrinology2001，124，： | 1 |
| 3 | Op- timal minimum distance-based precoder for MIMO spatial multiplexing systems 显示文摘 | COLLIN L BERDER O ROSTAING P BUREL a | 2004 | IEEE Transactions on Signal Processing2004，52，： | 1 |
| 4 | Digestibility of extruded peas,extruded lupin,and rapeseed meal in rainbow trout(Oncorhynchus mykiss) and turbot(Psetta maxima) 显示文摘 | Burel C Boujard T Tulli F | 2000 | Aquaculture2000，188，3： | 1 |
| 5 | Effect of past nutritional history and fasting on feed intake and growth in rainbow trout Oncorhynchus mykiss 显示文摘 | Boujard T Burel C Medale F | 2000 | A- quatic Living Resources2000，13，3： | 1 |
| 6 | Randomized con- trolled trial of cognitive behavioral therapy vs standard treat- ment to prevent recurrent cardiovascular events in patients with coronary heart disease: Secondary Prevention in Uppsala Pri- mary Health Care project (SUPRIM) 显示文摘 | Gulliksson M Burell G Vessby B | 2011 | Arch Intern Med2011，171，2： | 1 |
| 7 | Digestibility of extrude peas, extruded lupin, and rapeseed meal in rainbow trout ( Oncorhynchus mykiss ) and turbot ( Psetta maxima)显示文摘 | Burel C Boujard T Tulli F | 2000 | Aquaculture2000，188，34： | 1 |
| 8 | Extension of the MIMO precoder based on the minimum Euclidean distance: a cross-form matrix 显示文摘 | VRIGNEAU B LETESSIER J ROSTAING P COLLIN L BUREL G | 2008 | IEEE Journal of elected Topics in Signal Processing2008，2，2： | 1 |
| 9 | Dichotomy of AML1 - ETO functions: growth arrest versus block of differentiation 显示文摘 | Burel SA Harakawa N Zhou L | 2001 | Mol Cell Biol2001，21，16： | 1 |
| 10 | A robust synchronization procedure for blind estimation of the symbol period and the timing offset in spread spectrum transmissions 显示文摘 | Bouder C Azou S Burel G | 2002 | The 7th Internaional Symposium on Spread-Spectrum Techniques and Applications2002，，： | 1 |
| 11 | Isoelectric focusing a- nalysis of peroxidases in flax seedling hypocotyls grow in diffe- rent light conditions显示文摘 | BUREL C BERTHE T MERY J C | 1994 | Plant Physiology Biochemistry1994，32，： | 1 |
| 12 | Blind separation of sources:a nonlinear neural algorithm显示文摘 | BUREL G | 1992 | Neural Network1992，5，6： | 1 |
| 13 | OMERO: Flexible, model - driven data management for experimental biolo- gy 显示文摘 | Allan C Burel J M Moore J | 2012 | Nature Methods2012，9，3： | 1 |
| 14 | Blind recovery of k/n rate convolutional encoders in a noisy environment 显示文摘 | Marazin M Gautier R Burel G | 2011 | Wireless Communications and Networks2011，2011，1： | 1 |
| 15 | Blind separation of sources: a nonlinear neuralalgorithm显示文摘 | BUREL G | 1992 | Neural Networks1992，5，6： | 1 |
| 16 | Deletion of an AML1 -ETO C -terminal NcoR/SMRT- interacting region strongly induces leukemia development 显示文摘 | Yan M Burel A Peterson LF | 2004 | Proc Natl Acad Sci USA2004，101，17： | 1 |
| 17 | Porphyrins as light harvesters in the dye-sensitised TiO_ solar cell显示文摘 | Campbella W M Burell A K Officer D L | 2004 | Coordination Chemistry Reviews2004，248，1： | 1 |
| 18 | Stress, burnout and coping: Differences between women with coronary heart disease and healthy matched women 显示文摘 | Hallman T Thomsson H Burell G | 2002 | J Health Psychol2002，8，： | 1 |
| 19 | Blind separation of sources: a nonlinear neural algorithm 显示文摘 | Burel G | 1992 | Neural Networks1992，5，6： | 1 |
| 20 | Significant plain film findings in sigrnoid volvulus显示文摘 | Burell HC Baker DM Waldrop P | 1994 | Clin Radiol1994，49，： | 1 |
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