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| 1 | Autophagy in colorectal cancer:An important switch from physiology to pathology显示文摘Colorectal cancer(CRC) remains a leading cause of cancer death in both men and women worldwide.Among the factors and mechanisms that are involved in the multifactorial etiology of CRC,autophagy is an important transformational switch that occurs when a cell shifts from normal to malignant.In recent years,multiple hypotheses have been considered regarding the autophagy mechanisms that are involved in cancer.The currently accepted hypothesis is that autophagy has dual and contradictory roles in carcinogenesis,but the precise mechanisms leading to autophagy in cancer are not yet fully defined and seem to be context dependent.Autophagy is a surveillance mechanism used by normal cells that protects them from the transformation to malignancy by removing damaged organelles and aggregated proteins and by reducing reactive oxygen species,mitochondrial abnormalities and DNA damage.However,autophagy also supports tumor formation by promoting access to nutrients that are critical to the metabolism and growth of tumor cells and by inhibiting cellular death and increasing drug resistance.Autophagy studies in CRC have focused on several molecules,mainly microtubule-associated protein 1 light chain 3,beclin 1,and autophagy related 5,with conflicting results.Beneficial effects were observed for some agents that modulate autophagy in CRC either alone or,more often,in combination with other agents.More extensive studies are needed in the future to clarify the roles of autophagy-related genes and modulators in colorectal carcinogenesis,and to develop potential beneficial agents for the prognosis and treatment of CRC. | Florin Burada Elena Raluca Nicoli Marius Eugen Ciurea Daniel Constantin Uscatu Mihai Ioana Dan Ionut Gheonea | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 15 |
| 2 | Recent changes in reference evapotranspiration in Romania显示文摘 | Adina-Eliza Croitoru Adrian Piticar Carmen Sofia Dragot? Doina Cristina Burada | 2013 | Global and Planetary Change2013，，： | 2 |
| 3 | Production of a Mg-Nd alloy by direct electrolysis from an oxifluoride melt显示文摘 | Soare V Gurgu C Burada M Ostvold T Kontoyannis C | 2006 | Canadian Metallurgical Quarterly2006，45，2： | 1 |
| 4 | Entropic Splitter for Particle Separation显示文摘 | D Reguera A Luque P S Burada | 2012 | Physical Review Letters2012，108，02： | 1 |
| 5 | Production of a Mg-Nd alloy by direct electrolysis from an oxifluoride melt显示文摘 | Sore V Gurgu C Burada M | 2006 | Ca- nadian Metallurgical Quarterly2006，45，2： | 1 |
| 6 | Entropic stochastic resonance显示文摘 | Burada P S Sehmid G Reguera D | 2008 | Phys Rev Lett2008，101，： | 1 |
| 7 | Degradation at the industrial dispersion and waste gas chimneys: Case study显示文摘 | Burada C O | 2011 | Metalurgia International2011，16，1： | 1 |
| 8 | The effects of sintering on the photocatalytic activity of N-doped TiO2 nanoparticles 显示文摘 | Zhao Y X Qiu X F Burada C | 2008 | Chemistry of Material2008，20，： | 1 |
| 9 | IRGM gene polymorphisms and risk of gastric cancer 显示文摘 | Burada F Plantinga TS Ioana M | 2012 | J Dig Dis2012，13，7： | 1 |
| 10 | Entropic stochastic resonance: the constructive role of the unevenness显示文摘 | P. S. Burada G. Schmid D. Reguera J. M. Rubi P. H?nggi | 2009 | The European Physical Journal B2009，，1： | 1 |
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