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| 1 | Macrophage depletion and Schwann cell transplantation reduce cyst size after rat contusive spinal cord injury显示文摘Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury(SCI) and is currently in clinical trials.In our continuing efforts to improve Schwann cell transplantation strategies,we sought to determine the combined effects of Schwann cell transplantation with macrophage depletion.Since macrophages are major inflammatory contributors to the acute spinal cord injury,and are the major phagocytic cells,we hypothesized that transplanting Schwann cells after macrophage depletion will improve cell survival and integration with host tissue after SCI.To test this hypothesis,rat models of contusive SCI at thoracic level 8 were randomly subjected to macrophage depletion or not.In rat subjected to macrophage depletion,liposomes filled with clodronate were intraperitoneally injected at 1,3,6,11,and 18 days post injury.Rats not subjected to macrophage depletion were intraperitoneally injected with liposomes filled with phosphate buffered saline.Schwann cells were transplanted 1 week post injury in all rats.Biotinylated dextran amine(BDA) was injected at thoracic level 5 to evalute axon regeneration.The Basso,Beattie,and Bresnahan locomotor test,Gridwalk test,and sensory test using von Frey filaments were performed to assess functional recovery.Immunohistochemistry was used to detect glial fibrillary acidic protein,neurofilament,and green fluorescent protein(GFP),and also to visulize BDA-labelled axons.The GFP labeled Schwann cell and cyst and lesion volumes were quantified using stained slides.The numbers of BDA-positive axons were also quantified.At 8 weeks after Schwann cell transplantation,there was a significant reduction in cyst and lesion volumes in the combined treatment group compared to Schwann cell transplantation alone.These changes were not associated,however,with improved Schwann cell survival,axon growth,or locomotor recovery.Although combining Schwann cell transplantation with macrophage depletion does improve histopathology of the injury site,the effect on axon growth and behavioral recovery appears no better than what can be achieved with Schwann cell transplants alone. | Yee-Shuan Lee Lucy H.Funk Jae K.Lee Mary Bartlett Bunge | 2018 | Neural Regeneration Research2018，13，4： | 4 |
| 2 | 湿强剂用于造纸引发的环境问题显示文摘在造纸过程中主要根据纸张生产过程的条件选择湿强剂。在中性或弱碱性条件下,最好的湿强剂是聚酰胺-表氯醇(PAE)树脂,其可以提供最好的湿强效果。 | Bung Josef Diana Braga 顾海强 王继猛 游小庆 奚伟伟 | 2008 | 国际造纸2008，27，4： | 3 |
| 3 | Surface sizing agent显示文摘 | Bung J | 2004 | Quarterly Jour-hal of Indian Pulp And PAper Technical Association2004，6，5： | 1 |
| 4 | Schwann cell transplantation:A repair strategy for spinal cord injury显示文摘 | Wiliams RR Bunge MB | | 0，，： | 1 |
| 5 | Multisolute extraction of organic acids by emulsion liquid membranes显示文摘 | Wang C C Bunge A L | 1990 | I J Memb Sci1990，53，12： | 1 |
| 6 | Surface sizing agents显示文摘 | Bung J | 2004 | Quarterly Journal of Indian Pulp and Paper Technical Association2004，16，3： | 1 |
| 7 | Transplantation of purified populations of Schwann cells into lesioned adult rat spinal cord 显示文摘 | Bunge MB | 1994 | J Neurol1994，242，11： | 1 |
| 8 | Characterization of children's decision making:Sensitivity to punishment frequency,not task complexity显示文摘 | CRONE E A BUNGE S A LATENSTEIN H | 2005 | Child Neuropsychology2005，11，3： | 1 |
| 9 | Apoptosis alter traumatic human spinal cord injury显示文摘 | Emery E Aldana P Bunge MB | 1998 | J Neurosurg1998，89，6： | 1 |
| 10 | Apoptosis after traumatic human spinal cord injury显示文摘 | Emery E Aldana P Bunge MB | | 0，，06： | 1 |
| 11 | A multifunctional neurotrophin with reduced affinity to p75NTR enhances transplanted Schwann cell survival and axon growth after spinal cord injury显示文摘 | Enomoto M Bunge MB Tsoulfas P | | 0，，： | 1 |
| 12 | Characterization of photochemically induced spinal cord injury in the rat by light and electron microscopy显示文摘 | Bunge MB Holets VR Bates ML | 1994 | Exp Neurol1994，127，1： | 1 |
| 13 | Acute tranmatic central cord syndrome : MRI-pathological correlations 显示文摘 | Queneer RM Bunge RP Egnor M | 1992 | Neuroradiology1992，34，2： | 1 |
| 14 | Apoptosis after traumatic human spinal cord injury显示文摘 | Emery E Aldana P Bunge MB | 1998 | J Neurosury1998，89，： | 1 |
| 15 | Release of autocrine growth factor by primary and immortalized Schwann cells 显示文摘 | Porter S Glaser L Bunge R | 1987 | Proe Natl Acad Sci USA1987，84，21： | 1 |
| 16 | Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration 显示文摘 | Bunge RP | 1993 | Curr Opin Neurobiol1993，3，： | 1 |
| 17 | Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?显示文摘 | Courtine G Bunge M B Fawcett J W | 2007 | Nat Med2007，13，： | 1 |
| 18 | Characterization of Damaged Skin by Imedance Spec- troscopy: Mechanical Damage 显示文摘 | White Erick A Orazem Mark E Bunge Annette L | 2013 | Pharmaceutical Research2013，30，8： | 1 |
| 19 | The efficacy of retreatment with the same medication for early treatment failure of bacterial vaginosis 显示文摘 | Bunge KE Beigi RH Meyn LA | 2009 | Sex Transm Dis2009，36，11： | 1 |
| 20 | Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord显示文摘 | FOUAD K SCHNELL L BUNGE M B | 2005 | J Neurosci2005，25，5： | 1 |
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