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| 1 | Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology显示文摘Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efficacy in a clinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in clinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinflammation. At the present time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity, hypertension, diabetes and atherosclerosis could act as 'silent contributors' promoting a chronic proinflammatory state. This could aggravate the outcome of various pathological entities and can contribute to a number of subsequent post-stroke complications such as dementia, depression and neurodegeneration creating a pathological vicious cycle. Moreover, recent data suggests that the inflammatory process might be closely linked with multiple neurodegenerative pathways related to depression. In addition, pro-inflammatory cytokines could play a central role in the pathophysiology of both depression and dementia. | Raluca Elena Sandu Ana Maria Buga Adriana Uzoni Eugen Bogdan Petcu Aurel Popa-Wagner | 2015 | Neural Regeneration Research2015，10，9： | 6 |
| 2 | Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide显示文摘 | Ignerro LJ Buga GM Wood KS | 1987 | Proc Natl Acad Sci USA1987，84，24： | 1 |
| 3 | Entothelium derived relaxing factor produced and released from artery and vein in nitric oxide显示文摘 | Ignarro LJ Buga CM Wood KS | 1987 | Proc Natl Aead Sei USA1987，84，24： | 1 |
| 4 | Enthotheliumderived relaxing factor produced and released from artery and vein is nitric oxide显示文摘 | Ignarro L I Buga G M Wood K S | 1987 | Proc Natl Acad Sci1987，84，24： | 1 |
| 5 | Negative feedback regulation of endothelial cell function by nitric oxide显示文摘 | Buga GM Griscavage JM Rogers NE | 1993 | Circ Res1993，73，5： | 1 |
| 6 | Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical显示文摘 | Ignarro LJ Byrns RE Buga GM | 1987 | Circ Res1987，61，6： | 1 |
| 7 | High-pres sure polymerized phases of C60显示文摘 | Blank V D Buga S G Dubitsky G A | 1998 | Carbon1998，36，4： | 1 |
| 8 | Endothelium-derived relaxing factor produced and released from artery and veinis nitric oxide显示文摘 | lgnerro L J Buga GM Wood KS | 1997 | Proc Natl AcadSci USA1997，84，24： | 1 |
| 9 | Exercise testing and training of apparently healthy Individuals 显示文摘 | Buga G W | 1997 | Jouranal of Athletic Training1997，32，3： | 1 |
| 10 | Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle 显示文摘 | Ignarro LJ Bush PA Buga GM | 1990 | Biochem Biophys Res Commum1990，170，2： | 1 |
| 11 | Complications of emergency intubation with and without paralysis 显示文摘 | Li J Murphy-Lavoie H Bugas C | 1999 | Am J Emerg Med1999，17，2： | 1 |
| 12 | Cellular and molecular mechanisms underlying neurorehabilitation after stroke in aged sub- jects显示文摘 | Buga AM Dunoiu C Bleanu A | 2008 | Rom J Morphol Embryol2008，49，3： | 1 |
| 13 | Apolipoprotein A-I mimetic peptides显示文摘 | Brian J. Lenten Alan C. Wagner G. M. Anantharamaiah Mohamad Navab Srinivasa T. Reddy Georgette M. Buga Alan M. Fogelman | 2009 | Current Atherosclerosis Reports2009，，1： | 1 |
| 14 | Strategies to im- prove post-stroke behavioral recovery in aged subjects 显示文摘 | Buga A Balseanu A Popa-Wagner A | 2009 | Rom J Morphol Embryol2009，50，4： | 1 |
| 15 | Endothelium-derived relaxing factor prod uced and released from artery and vein is nitric oxide 显示文摘 | Lgnarro LJ Buga GM Wood KS | 1997 | Proc Natl Acad Sci USA1997，84，24： | 1 |
| 16 | Clinical trials update from the American Heart Association meeting 2010 : EMPHASIS-HF, RAFT, TIM-HF, Tele-HF, ASCEND-HF, ROCKET-AF, and PROTECT 显示文摘 | Cleland JG Coletta AP Buga L | 2011 | Eur Heart Fail2011，13，4： | 1 |
| 17 | Shear stress - induced release of nitric oxide from endothelial cells grown on beads显示文摘 | Buga GM Gold ME Fukuto JIM | 1991 | Hypertension1991，17，2： | 1 |
| 18 | Inhibitors of nitric oxide promote microvascular thrombosis显示文摘 | Azizzadeh B Buga GM Berke GS | 2003 | Arch Facial Plast Surg2003，5，1： | 1 |
| 19 | Endothelium - derived relaxing factor produced and released from artery and vein is nitric oxide 显示文摘 | Lgnarro LJ Buga GM Wood KS | 1997 | Proc Natl Acad Sci USA1997，84，： | 1 |
| 20 | Is C60 fullerite harder than diamond?显示文摘 | BLANK V POPOV M BUGA S | 1994 | Physics Letters A1994，188，3： | 1 |
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