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| 1 | Impaired coagulation,liver dysfunction and COVID-19:Discovering an intriguing relationship显示文摘Coronavirus disease 2019(COVID-19)is,at present,one of the most relevant global health problems.In the literature hepatic alterations have been described in COVID-19 patients,and they are mainly represented by worsening of underlying chronic liver disease leading to hepatic decompensation and liver failure with higher mortality.Several potential mechanisms used by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)to cause liver damage have been hypothesized.COVID-19 primary liver injury is less common than secondary liver injury.Most of the available data demonstrate how liver damage in SARSCo V-2 infection is likely due to systemic inflammation,and it is less likely mediated by a cytopathic effect directed on liver cells.Moreover,liver alterations could be caused by hypoxic injury and drugs(antibiotics and non-steroidal antiinflammatory drugs,remdesivir,tocilizumab,tofacitinib and dexamethasone).SARS-Co V-2 infection can induce multiple vascular district atherothrombosis by affecting simultaneously cerebral,coronary and peripheral vascular beds.Data in the literature highlight how the virus triggers an exaggerated immune response,which added to the cytopathic effect of the virus can induce endothelial damage and a prothrombotic dysregulation of hemostasis.This leads to a higher incidence of symptomatic and confirmed venous thrombosis and of pulmonary embolisms,especially in central,lobar or segmental pulmonary arteries,in COVID-19.There are currently fewer data for arterial thrombosis,while myocardial injury was identified in 7%-17%of patients hospitalized with SARS-Co V-2 infection and 22%-31%in the intensive care unit setting.Available data also revealed a higher occurrence of stroke and more serious forms of peripheral arterial disease in COVID-19 patients.Hemostasis dysregulation is observed during the COVID-19 course.Lower platelet count,mildly increased prothrombin time and increased Ddimer are typical laboratory features of patients with severe SARS-Co V-2 infection,described as“COVID-19 associated coagulopathy.”These alterations are correlated to poor outcomes.Moreover,patients with severe SARS-Co V-2 infection are characterized by high levels of von Willebrand factor with subsequent ADAMTS13 deficiency and impaired fibrinolysis.Platelet hyperreactivity,hypercoagulability and hypofibrinolysis during SARS-Co V-2 infection induce a pathological state named as“immuno-thromboinflammation.”Finally,liver dysfunction and coagulopathy are often observed at the same time in patients with COVID-19.The hypothesis that liver dysfunction could be mediated by microvascular thrombosis has been supported by postmortem findings and extensive vascular portal and sinusoidal thrombosis observation.Other evidence has shown a correlation between coagulation and liver damage in COVID-19,underlined by the transaminase association with coagulopathy,identified through laboratory markers such as prothrombin time,international normalized ratio,fibrinogen,D-dimer,fibrin/fibrinogen degradation products and platelet count.Other possible mechanisms like immunogenesis of COVID-19 damage or massive pericyte activation with consequent vessel wall fibrosis have been suggested. | Damiano D'Ardes Andrea Boccatonda Giulio Cocco Stefano Fabiani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone Francesco Cipollone | 2022 | World Journal of Gastroenterology2022，28，11： | 5 |
| 2 | Fertility preservation after bilateral severe testicular trauma显示文摘 | Giovanni Liguori Nicola Pavan Gianluca d'Aloia Stefano Bucci Bernardino de Concilio Giorgio Mazzon Giangiacomo Ollandini Carlo Trombetta | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 3 | Cardiovascular outcome in treated hypertensive patients with responder,masked,false resistant,and true resistant hypertension显示文摘 | Pierdomenieo SD Lapenna D Bucci A | 2005 | Am J Hypertens2005，18，11： | 1 |
| 4 | Precision determination of lattice parameters and coefficients of thermal expansion of BiFeO3显示文摘 | Bucci J D Robertson B K James W J | 1972 | J Appl Cryst1972，5，： | 1 |
| 5 | Final report of a pilottrial of accelerated radiotherapy plus concurrent 96-hour infusional paclitaxel for locally advanced head and neck cancer显示文摘 | Bucci M K Rosenthal D I Hershock D | 2004 | Am J Clin Oncol2004，27，6： | 1 |
| 6 | Central nicotinic cho- linergic systems: A role in the cognitive dysfunction in At- tentionDeficit/Hyperactivity Disorder? 显示文摘 | Potter AS Newhouse PA Bucci D J | 2006 | Behav Brain Res2006，，： | 1 |
| 7 | In vivo delivery of the caveolin-I scaffolding domain inhibits nitric oxide synthesis and reduces inflammation 显示文摘 | Bucci M Gratton J P Rudic R D | 2000 | Nature Med2000，6，2： | 1 |
| 8 | Increased temporal disper- sion of myocardial repolarization in myotonic dystrophy type 1 : be- yond the cardiac conduction system 显示文摘 | Magrl D Piccirillo G Bucci E | 2012 | Int J Cardiol2012，156，3： | 1 |
| 9 | Cardiovascular and renal events in uncomplicated mild hypertensive patients with sustained and white coat hypertension 显示文摘 | Pierdomenico SD Lapenna D Bucci A | 2004 | Am J Hypertens2004，17，10： | 1 |
| 10 | Final report of a pilot trial of accelerated radiotherapy plus concurrent 96- hour infusional paclitaxel for locally advanced head and neck cancer显示文摘 | BUCCI M K ROSENTHAL D I HERSHOCK D | 2004 | Am J Clin Oncol2004，27，6： | 1 |
| 11 | Cardiovascular outcome in treated hypertensive patients with responder,masked,false resistant,and true resistant hypertension显示文摘 | Lapenna D Bucci A | 2005 | Am J Hypertens2005，18，： | 1 |
| 12 | Cardiovascular outcome in treated hypertensive patients with responder,masked,false resislant,and true resistant hypertension显示文摘 | Pierdomenico SD Lapenna D Bucci A | 2005 | Am J Hypertens2005，18，： | 1 |
| 13 | Circulating homocysteine levels in sustained and white coat hypertension显示文摘 | Pierdomenico S D Bucci A Lapenna D | 2003 | Journal of human hypertension2003，17，3： | 1 |
| 14 | Circulating homo-cysteine levels in sustained and white coat hypertension显示文摘 | Pierdomenico S D Bucci A Lapeuna D | 2003 | J Hum Hypertens2003，17，3： | 1 |
| 15 | Synthesis ofisophoric sparse array allowing zoomable beams and ar-bitrary coverage in satellite communications显示文摘 | BUCCI O M PERNA S PINCHERA D | 2015 | IEEETransactions on Antennas and Propagation2015，63，4： | 1 |
| 16 | 400 MW SMES power conditioning system development and simulation显示文摘 | Bucci B M Swe K T | 1993 | IEEE Transactions on Power Electronics1993，8，3： | 1 |
| 17 | Cardiovascular outcome in treated hypertensive patients with responder, masked, false resistant,and true resistant hypertension 显示文摘 | Pierdomenico SD Lapenna D Bucci A | 2005 | Am J Hypertens2005，18，： | 1 |
| 18 | Realization of a 980-nm/1550-nm pump-signal (De) multiplexer made by ionexchange on glass using a segmented asymmetric Y-Junction显示文摘 | Bucci D Grelin J Ghibaudo E Broquin J-E | | 0，，09： | 1 |
| 19 | Effects of antioxidants on boar spermatozoa during sorting and storting显示文摘 | VALLORANI C SPINACI M BUCCI D | 2010 | Animal Repoduction Science2010，122，12： | 1 |
| 20 | Leukoencephalomalacia and hemorrhage in the brain of rabbits gavaged with mycotoxin fumonisin B1 显示文摘 | Bucci T J Hansen D K Laborde J B | 1996 | Natural Toxins1996，4，1： | 1 |
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