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| 1 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Effects of antioxidants on post-thawed bovine spermand oxidative stress parameters : antioxidants protectDNA integrity against cryodamage 显示文摘 | BUCAK M N TUNCER P B SARIOZKAN S | 2010 | Cryobiology2010，61，3： | 1 |
| 3 | Protein separations using colloidal magnetic nanoparticles显示文摘 | Bucak S Jones D A Laibinis P E | 2003 | Biotechnol Prog2003，19，： | 1 |
| 4 | Primary adrenal insufficiency caused by a novel mutation in DAX1 gene 显示文摘 | Evliyaolu O Dokurel i Bucak F | 2013 | J Clin Res Pediatr Endocrinol2013，5，1： | 1 |
| 5 | Effects of anti-oxidant additives on microscopic and oxidative parameters of Angora goat semen following the freeze-thawing process显示文摘 | Atessahin A Bucak M N Tuncer P B | 2008 | Small Ruminant Research2008，，77： | 1 |
| 6 | Postoperative cognitive dysfunction in living liver transplant donors显示文摘 | Bucak N BegeZ Erdil F | 2014 | Exp Clin Transplant2014，，1： | 1 |
| 7 | Multiple kernel learning for visualobject recognition: a review显示文摘 | Bucak S S Jin R Jain A K | 2014 | IEEE Transactions on PatternAnalysis and Machine Intelligence2014，36，7： | 1 |
| 8 | Enhancement ofoxygen mass transfer using functionalized magneticnanoparticles显示文摘 | Olle B Bucak S C Holmes T | 2006 | Industrial&Engineering ChemistryResearch2006，45，12： | 1 |
| 9 | Multiple Kernel Learning for Visual Object Recognition: a Review 显示文摘 | Bucak S S Rong J Jain A K | 2014 | IEEE Transactions on Pattern Analysis and Machine Intelligence2014，36，7： | 1 |
| 10 | Effects of oxidized glutathione, bovine se- rum albumin, cysteine and llycopene on the quality of frozen- thawed ramsemen显示文摘 | Uysal O Bucak M N | 2007 | ActaVet Brno2007，76，： | 1 |
| 11 | Incremental subspace learning via non-negative matrix factorization 显示文摘 | BUCAK S S GUNSEL B | 2009 | Pattern Recognition2009，42，5： | 1 |
| 12 | 显示文摘 | Bucak S Jones D A Laibinis P E | 2003 | Biotech Prog2003，19，2： | 1 |
| 13 | Protein separations using colloidal magnetic nanoparticles显示文摘 | Bucak S Jones D A | 2003 | Bioteclmol Prog2003，19，： | 1 |
| 14 | Protein separations using colloidal magnetic nanoparticles 显示文摘 | Bucak S Jones D A Laibinis P E | 2003 | Biotechnology Progress2003，19，2： | 1 |
| 15 | 查看详情显示文摘 | Olle B Bucak S Homles T C | | 0，，12： | 1 |
| 16 | Multiple kernel learning for visual object recognition: A review 显示文摘 | Bucak S Jin R Jain A | 2013 | Pattern Analysis and Machine Intelligence IEEE Transactions on2013，36，7： | 1 |
| 17 | The effect of beta receptor blockadethrough propranolol on corneal neovascularization 显示文摘 | SIMAVU H ERDURMUS M TERZI EH BUCAK YY ONDERHI KUKNER AS | 2014 | J Oc-ul Pharmacol Therapeut2014，30，： | 1 |
| 18 | Incremental subspace learning via non-negative matrix factorization显示文摘 | Bucak S S Gunsel B | 2009 | Pattern Recognition2009，42，5： | 1 |
| 19 | The effect of optical glass facades and its anisotropies on building measurement methods显示文摘 | M. lllguth C. Schulera O. Bucak | 2015 | Frontiers of Architectural Research2015，4，2： | 1 |
| 20 | Multiple kernel learning for visual object recognition:A review显示文摘 | Bucak S S Jin R Jain A K | 2014 | IEEE Transactions on Pattern Analysis and Machine Intelligence2014，36，7： | 1 |
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