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| 1 | 限制性与自由输血策略对心血管疾病患者非心脏手术效果的影响:系统回顾与Meta分析显示文摘目的比较采取限制性与自由输血策略的心血管疾病患者的非心脏手术结局。数据来源搜集涉及医院红细胞输注阈值的随机控制试验。检索CENTRAL、Medline、EMBase、CINAHL、PubMed、LILACS、NHSBT输血证据库、Clinical Trials.gov、WHO国际临床试验注册平台、国际标准随机对照临床试验编号登记、欧盟临床试验登记。检索时间为2015-11-02之前。试验选择选取发表与未发表的比较限制性与自由输血阈值的随机控制试验,试验均纳入心血管疾病患者。结果检索到41项试验,其中7项试验纳入心血管疾病患者。另选取4项纳入心血管疾病患者的试验。最终共搜集11项纳入心血管疾病患者(n=3 033)的试验进行Meta分析(限制性输血1 514例,自由输血1 519例)。输血阈值与30 d死亡率之间联系的汇集风险比例为1.15〔95%CI(0.88,1.50),P=0.50〕,异质性较小(I^2=14%)。限制性输血患者的急性冠脉综合征风险与自由输血患者相比更高〔9项试验;风险比例1.78,95%CI(1.18,2.70),P=0.01,I^2=0%〕。结论对急性冠脉综合征或慢性心血管疾病患者采取80 g/L以下的限制性输血阈值可能并不安全,对病死率与其他结局的影响并不确定。这些数据可暂时支持对急性或慢性心血管疾病患者使用更加自由的输血阈值(>80 g/L),但有待更具有说服力的高质量的心血管疾病患者随机试验进行验证。 | Docherty AB O' Donnell R Brunskill S 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 12 |
| 2 | Fayetteville Green Lake,USA,VIII,Mass balance for ^137Cs in water,varved and non-varved sediments显示文摘 | Brunskill G J | 1984 | Chemical Geology1984，44，： | 1 |
| 3 | Inspiratory and expiratory steady flow analysis in a model symmetrically bifurcating airwway显示文摘 | Brunskill C T Lieber B B | 1997 | ASME Journal of Biomechanical Engineering1997，119，： | 1 |
| 4 | Changes in the gone expression programs of renal mesangial cells during diabetic nephropathy显示文摘 | Brunskill EW Potter SS | 2012 | BMC Nephrol2012，13，： | 1 |
| 5 | Distinct path- ways regulate proapoptotic Nix and BNip3 in cardiac stress 显示文摘 | Galvez A S Brunskill E W Marreez Y | 2006 | J Biol Chem2006，281，3： | 1 |
| 6 | Transfhsion of fresher wrsus older red blood cells for all conditions 显示文摘 | Brunskill SJ Wilkinson KL Doree C | 2015 | Cochrane Database Syst Rev2015，，： | 1 |
| 7 | Early diagenetic cycling,incineration, and burial of sedimentary organic carbon in the central Gulf of Papua (Papua New Guinea) 显示文摘 | ALLER R C BLAIR N E BRUNSKILL G J | 2008 | Journal of Geophysical Research2008，113，： | 1 |
| 8 | SPINK1/PSTI Polymorphisms Act as Disease Modifiers in Familial and Idiopathic Chronic Pancreatitis显示文摘 | Roland H. Pfützer* M.Michael Barmada? Andrew P.J. Brunskill§ ∥ Robert Finch* ? P.Suzanne Hart? ? John Neoptolemos# William F. Furey§ ∥ David C. Whitcomb* ?? ** ?? | 2000 | Gastroenterology2000，，3： | 1 |
| 9 | Inspiratory and expiratory steady flow analysis in a model symmewically bifurcating airway 显示文摘 | Zhao Y Brunskill CT Lieber BB | 1997 | ASME Journal of Biomeehanieal Engineering (S0148-0731)1997，119，2： | 1 |
| 10 | Organochlorine Pesticide Residues in Soils and Sediments of the Herbert and Burdekin River Regions, North Queensland-hnplications for Contamination of the Great Barrier Reef 显示文摘 | Cavanagh J E Burns K A Brunskill G J | 1999 | Marine Pollution Bulletin1999，39，112： | 1 |
| 11 | Long-Term Exposure of Proximal Tubular Epithelial Cells to Glucose Induces Transforming Growth Factor-β1 Synthesis via an Autocrine PDGF Loop显示文摘 | Donald Fraser Nigel Brunskill Takafumi Ito Aled Phillips | 2003 | The American Journal of Pathology2003，，6： | 1 |
| 12 | C-peptide as a therapeutic tool in diabetic nephropathy显示文摘 | Hills C E Brunskill N J Squires P E | 2010 | Am J Nephrol2010，31，5： | 1 |
| 13 | Activation of mitogenic pathways by albumin in kidney proximal tubule epithelial cells: implications for the pathophysiology of proteinuric slates 显示文摘 | DIXON R BRUNSKILL NJ | 1999 | J Am Soe Nephrol1999，10，7： | 1 |
| 14 | The molecular interactions between filtered proteins and proximal tubular cells in proteinuria显示文摘 | Baines RJ Brunskill NJ | 2008 | Nephron Exp Nephrol2008，101，2： | 1 |
| 15 | C-peptide signals via God to protect against TNF-α-mediated apoptosis of opossum kidney proximal tubular cells 显示文摘 | Al-Rasheed NM Willars GB Brunskill NJ | 2006 | J Am Soc Nephrol2006，17，4： | 1 |
| 16 | Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomes显示文摘 | Clifford DM Fisher SA Brunskill S J | 2012 | PLoS One2012，7，37： | 1 |
| 17 | SPINK 1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis显示文摘 | Pfutzer RH Barmda MM Brunskill AP | 2000 | Gastroenterology2000，119，3： | 1 |
| 18 | Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop显示文摘 | FraserD Brunskill N Ito T | 2003 | Am J Pathol2003，163，6： | 1 |
| 19 | Perceptual switch rates with ambiguous structure-from-motion figures in bipolar disor- der显示文摘 | Krug K Brunskill E Scarna A | 2008 | Proc Biol Sci2008，275，1645： | 1 |
| 20 | Incorporating expert knowledge when learning Bayesian network structure: a medical case study 显示文摘 | Julia Flores M Nicholson A E Brunskill A | 2011 | Artificial Intelligence in Medicine2011，53，3： | 1 |
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