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| 1 | Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism?显示文摘The balance of autophagy, apoptosis and necroptosis is crucial to determine the outcome of the cellular response to cholesterol dysregulation. Cholesterol plays a major role in regulating the properties of cell membranes, especially as regards their fluidity, and the regulation of its biosynthesis influences the shape and functions of these membranes. Whilst dietary cholesterol can easily be distributed to most organs, the central nervous system, whose membranes are particularly rich in cholesterol, mainly relies on de novo synthesis. For this reason, defects in the biosynthesis of cholesterol can variably affect the development of central nervous system. Moreover, defective synthesis of cholesterol and its intermediates may reflect both on structural cell anomalies and on the response to inflammatory stimuli. Examples of such disorders include mevalonate kinase deficiency, and Smith-Lemli-Opitz syndrome, due to deficiency in biosynthetic enzymes, and type C Niemann-Pick syndrome, due to altered cholesterol trafficking across cell compartments. Autophagy, as a crucial pathway dedicated to the degradation of cytosolic proteins and organelles, plays an essential role in the maintenance of homeostasis and in the turnover of the cytoplasmic material especially in the presence of imbalances such as those resulting from alteration of cholesterol metabolism. Manipulating the process of autophagy can offer possible strategies for improving neuronal cell viability and function in these genetic disorders. | Elisa Piscianz Liza Vecchi Brumatti Alberto Tommasini Annalisa Marcuzzi | 2019 | Neural Regeneration Research2019，14，4： | 2 |
| 2 | The Complex Interaction between Home Environment, Socioeconomic Status, Maternal IQ and Early Child Neurocognitive Development: a Multivariate Analysis of Data Collected in a Newborn Cohort Study 显示文摘 | Ronfanl L Vecchi Brumatti L Mariuz M | 2015 | Plos One2015，10，01： | 1 |
| 3 | Curcumin and Inflammatory Bowel Dis- ease: Potential and Limits of Innovative Treatments 显示文摘 | VECCHI BRUMATTI L MARCUZZI A TRICARI- CO PM | 2014 | Molecules2014，19，： | 1 |
| 4 | First trimester maternal serum PIGF, free β-hCG, PAPP-A, PP-13, uterine artery Doppler and maternal history for the prediction of preeclampsia显示文摘 | G. Di Lorenzo M. Ceccarello V. Cecotti L. Ronfani L. Monasta L. Vecchi Brumatti M. Montico G. D’Ottavio | 2012 | Placenta2012，，6： | 1 |
| 5 | Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival显示文摘 | Elgendy M Sheridan C Brumatti G | 2011 | Mol Cell2011，42，： | 1 |
| 6 | Oncogenic Ras-inducedexpression of Noxa and Beclin-I promotes autophagic cell death andlimits clonogenic survival显示文摘 | Elgendy M Sheridan C Brumatti G | 2011 | Mol Cell2011，42，1： | 1 |
| 7 | Apoptosomes: protease activation platforms to die from显示文摘 | Adrain C Brumatti G Martin SJ | 2006 | Trends Biochem Sci2006，31，5： | 1 |
| 8 | Apoptosomes protease activation platforms to die from 显示文摘 | Adrain C Brumatti G Martin SJ | 2006 | Trends Biochemical Sci2006，31，5： | 1 |
| 9 | Expression and purification of recombinant annexin Ⅴ for the detection of membrane alterations on apoptotic cells 显示文摘 | Brumatti G Sheridan C Martin SJ | 2008 | Methods2008，44，3： | 1 |
| 10 | Expression and purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells 显示文摘 | Brumatti G Sheridan C Martin SJ | 2008 | Methods2008，44，3： | 1 |
| 11 | A rapid and sensitive method for the screening of DNA intercalating antibiotics 显示文摘 | Furlan RLA Garrido LM Brumatti G | 2002 | Biotechnol Lett2002，24，21： | 1 |
| 12 | Oncogenic Ras-Induced expression of Noxa and beclin-1 promotes autophagic cell death and limits clonogenic survival显示文摘 | Elgendy M Sheridan C Brumatti G | 2011 | Mol Cell2011，42，1： | 1 |
| 13 | Expressionand purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells显示文摘 | BRUMATTI G SHERIDAN C MARTIN S J | 2008 | Methods2008，44，3： | 1 |
| 14 | Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim 显示文摘 | Sheridan C Brumatti G Martin SJ | 2008 | J Biol Chem2008，283，22： | 1 |
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