维普期刊资源整合服务平台（V6.5）

45篇 您的检索式：作者名="Bruk"

选中清除导出查看参考文献查看引证文献引用追踪共3页首页上一页第1页下一页末页 /3 跳转

	题名	作者	年代	出处	被引量
1	Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice显示文摘Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study, we discovered bivalent hormetic functions of PXR/CAR modulating the richness of the gut microbiome using genetically engineered mice. The absence of PXR or CAR increased microbial richness, and absence of both receptors synergistically increased microbial richness. PXR and CAR deficiency increased the pro-inflammatory bacteria Helicobacteraceae and Helicobacter. Deficiency in both PXR and CAR increased the relative abundance of Lactobacillus, which has bile salt hydrolase activity, corresponding to decreased primary taurine-conjugated bile acids(BAs) in feces, which may lead to higher internal burden of taurine and unconjugated BAs, both of which are linked to inflammation, oxidative stress, and cytotoxicity. The basal effect of PXR/CAR on the gut microbiome was distinct from pharmacological and toxicological activation of these receptors. Common PXR/CAR-targeted bacteria were identified, the majority of which were suppressed by these receptors. h PXR-TG mice had a distinct microbial profile as compared to wild-type mice. This study is the first to unveil the basal functions of PXR and CAR on the gut microbiome.	Mallory Little Moumita Dutta Hao Li Adam Matson Xiaojian Shi Gabby Mascarinas Bruk Molla Kris Weigel Haiwei Gu Sridhar Mani Julia Yue Cui	2022	Acta Pharmaceutica Sinica B2022，12，2：	2
2	Description of the vasospasm phenomena following perimesenc ephalic nonaneurysmal subarachnoid hemorrhage 显示文摘	Prat D Goren O Bruk B	2013	Biomed Res Int2013，2013，37：	1
3	Application of transcranial Doppler uhrasonography for the diagnosis of brain death 显示文摘	Hadani M Bruk B Ram Z	1999	Intensive Care Med1999，25，：	1
4	Modelling of long-term behaviour of cesium and strontium radionuclides in the Arctic environment and human exposure显示文摘	Golikov V Logacheva I Bruk G	2004	Journal of Environmental Radioactivity2004，74，13：	1
5	Recent progress in alcoholic liver diseases 显示文摘	Strubelt O Chung AS Bruk RF	1987	Toxicology1987，45，：	1
6	Modelling of long-term behaviour of caesium and strontium radionuclides in the Arctic environment and human exposure显示文摘	Golikov V Logacheva I Bruk G	2004	Journal of Environmental Radioactivity2004，74，13：	1
7	Application of transcranial doppler ultrasonography for the diagnosis of brain death显示文摘	Bruk B Ram Z	1999	Intensive Care Med1999，25，8：	1
8	Modelling of long-term behaviour of cesium and strontium radionuclides in the Arctic environment and human exposure 显示文摘	Golikov V Logacheva I Bruk G	2004	Journal of Environmental Radioactivity2004，74，13：	1
9	Recent progress in alcoholic liver diseases显示文摘	Strubelt O chung AS Bruk RF	1987	Toxicology1987，45，：	1
10	Measurement of the flow in coronary artery bypass grafts显示文摘	Bruk V Steriovsky A	2006	Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2006，150，1：	1
11	Application of transcranial Doppler ultrasonography for the diagnosis of brain death 显示文摘	Hadani M Bruk B Ram Z	1999	Intensive Care Med1999，25，8：	1
12	Modelling of long-term behaviour of cesium and strontium radionuclides in the Arctic environment and human exposure 显示文摘	Golikov V Logacheva I Bruk G	2004	Journal of Environmental Radioactivity2004，74，13：	1
13	X-linked agammaglobulinemia: report on an untited states registry of 201 patients显示文摘	Winkelstein JA Marino ML Lederman HM Jones SM Sullivan K Bruks AW	2006	Medicine (Baltimore)2006，85，4：	1
14	Transiently increased basilar artery flow velocity following severe head injury: a time course transcranial Doppler study 显示文摘	Bruk B Ram Z	1997	J Neurotrauma1997，14，9：	1
15	Endoscopic Rdial Artery Harvesting for Coronary Artery Bypass Grafting: First Experience 显示文摘	Simek M Marcian P Bruk V	2006	Rozhl Chit2006，85，8：	1
16	Modelling of long-term behaviour of cesium and strontium radionuclides in the Arctic environment and human exposure 显示文摘	Golikov V Logacheva I Bruk G	2004	Journal of Environmental Radioactivity2004，74，13：	1
17	Transcranial Doppler in vertebrobasilar vasospasm after subarachnoid hemorrhage 显示文摘	Soustiel JF Bruk B Shik B	1998	Neurosurgery1998，43，2：	1
18	Recent progress in alcoholic liver diseases显示文摘	Strubelt O Chung AS Bruk RF	1987	Toxicology1987，45，：	1
19	Applicon of transcranial Doppler ultrasonography for the diagnosis of brain death显示文摘	Hadani M Bruk B Ram Z	1999	Intensive Care Med1999，25，：	1
20	Replicating and extending past personality/job satisfaction meta-analyses显示文摘	Bruk L V Khoury H A Nixon AE	2009	Human Performance2009，22，15：	1

返回顶部每页显示：

共3页首页上一页第1页下一页末页 /3 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示