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| 1 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 2 | IFNr and lymphocytes prevent primary tumor development and shape tumor immunogenicity显示文摘 | SHANKARAN V IKEDA H BRUCE AT | 2001 | Nature2001，410，6832： | 2 |
| 3 | Interactive venation-based leaf shape modeling显示文摘 | Sung Min Hong Bruce Simpson Gladimir V G Baranoski | 2005 | Computer Animation and Virtual Worlds2005，16，34： | 1 |
| 4 | Vacuum degassing improves steel product显示文摘 | Bruce S Cheetham V Legge G | 2009 | Steel Times International2009，33，8： | 1 |
| 5 | Ximelagatran vs Low-Molecular-Weight Heparin and Warfarin for the Treatment of Deep Vein Thrombosis显示文摘 | Jena-Noel Fiessinger Menno V Huisman Bruce L Davidson | 2005 | JAMA2005，293，： | 1 |
| 6 | Psychological disorders in patients with evacuation disorders and constipation in a tertiary practice显示文摘 | Nehra V Bruce B K Rath-Harvey D M | 2000 | Am J Gastroenterol2000，95，7： | 1 |
| 7 | Selection and characterization of β-lactam-β-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 β-lactamase gene显示文摘 | Sergei B V Bruce G Lakshmi P K | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
| 8 | IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity显示文摘 | Shankaran V Ikeda H Bruce A T | 2001 | Nature2001，410，6832： | 1 |
| 9 | Psycho- logical disorders in patients with evacuation disordersand constipation in a tertiary practice显示文摘 | Nehra V Bruce BK Rath-Haroey DM | 2000 | Am J Gastro- enterol2000，95，7： | 1 |
| 10 | Prevalence of malnutrition in general medical patiems显示文摘 | Bruce R S Blackburn GL Joseph V etal | 1976 | JAMA1976，235，01： | 1 |
| 11 | Pyoderma gangrenosum treated withhyperbaric oxygen therapy显示文摘 | Wasserteil V Bruce S Sessoms S etal | 1992 | Int J Der matol1992，31，： | 1 |
| 12 | Obturator internus muscle abscess in a child:a case report显示文摘 | Bansal M Bhaliak V Bruce CE | 2008 | J Pediatr Orthop B2008，17，5： | 1 |
| 13 | Influences of familiarity on the processing of faces显示文摘 | Bruce V | 1986 | Perception1986，15，： | 1 |
| 14 | Interactive venation-based leaf shape modeling显示文摘 | Sung Min Hong Bruce Simpson Gladimir V G Baranoski | 2005 | Computer Animation and Virtual Worlds2005，16，34： | 1 |
| 15 | IFN-γ lymphocytes prevent primary tumor development and shape tumor immunogenicity显示文摘 | Shankaran V Ikeda H Bruce AT | 2001 | Nature2001，410，： | 1 |
| 16 | Iron and cobalt ethylene polymerization catalys bearing 2,6-bis (imino) pyridyl ligands: synthesis, structures,and polymerization studies 显示文摘 | BRITOVSEK G J P BRUCE M GIBSON V C | 1999 | Journal of American Chemical Society1999，121，38： | 1 |
| 17 | Dry vacuum aids steel degassing显示文摘 | Bruce S Cheetham V | 2009 | Vacuum Challenges and Solutlons2009，，8： | 1 |
| 18 | The effect of seat geometry on gate valve noise显示文摘 | Smith Bruce A W Luloff Brian V | 2000 | Pressure Vessel Technology2000，122，4： | 1 |
| 19 | IFN gamma and lymphocytes prevent primary tmnour development and shape tumour immunogenicity 显示文摘 | Shankaran V Ikeda H Bruce AT | 2001 | Nature2001，410，： | 1 |
| 20 | Expression of biologi- cally active recombinant porcine interleukin-12 from Escherichia coli 显示文摘 | Morris KR Bruce MP Janardhana V | 2008 | Vet Immunol Immunopathol2008，126，34： | 1 |
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