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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Prevalence of malnutrition in general medical patients显示文摘 | Bruce RS Blackburn GI Joseph Vitale | 1976 | JAMA1976，235，4： | 1 |
| 3 | 1-Formylpiperazine and related compounds 显示文摘 | Bruce WH Morris F Geroge RS | 1955 | J Am Chem Soc1955，77，： | 1 |
| 4 | The tongue in clinical diagnosis显示文摘 | RS Rogers Ⅲ AJ Bruce | 2004 | Journal of the European Academy of Dermatology and Venereology2004，18，3： | 1 |
| 5 | 1-Formylpiperazine and related compounds显示文摘 | Bruce WH Morris F Geroge RS | 1955 | J Am Chem Soc1955，77，3： | 1 |
| 6 | Locking Plates: Tips and Tricks 显示文摘 | Wade RS Bruce HZ Jeff OA | 2007 | Bone Joint Sury Am2007，89，10： | 1 |
| 7 | The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice显示文摘 | Bruce CR Risis S Babb JR Yang C Lee-Young RS Henstridge DC | 2013 | Endocrinology2013，154，1： | 1 |
| 8 | Prevalence of malnutrition in general medical patients显示文摘 | Bruce RS Blackburn GL Joseph Vitale | 1976 | JAMA1976，235，4： | 1 |
| 9 | Successful treatment of complex aphthosis with colchicine and dapsone显示文摘 | Lynde CB Bruce AJ Rogers RS 3rd | 2009 | Arch Dermatol2009，145，3： | 1 |
| 10 | Oral manifesiations of sexually transmitted diseases显示文摘 | Bruce A J Rogers RS | 2004 | Clin dennatol2004，22，6： | 1 |
| 11 | 1-Formylpiperazine and related compounds显示文摘 | Bruce WH Morris F Geroge RS | 1955 | J Am Chem Soc1955，77，3： | 1 |
| 12 | Prevalence of malnutrition in general medical patients 显示文摘 | Bruce RS Blackburn GL Joseph Vitale | 1976 | JAMA1976，235，4： | 1 |
| 13 | Prevalence of malnutrition in general medical patients 显示文摘 | Bruce RS Blackburn GL Joseph V | 1976 | JAMA1976，235，4： | 1 |
| 14 | Prevalence of malnutrition in general medical patients 显示文摘 | Bruce RS Blackburn GL Joseph V | 1976 | JAMA1976，235，4： | 1 |
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