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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Deep venous thrombosis with suspected pulmonary embolism : detection with combined CT venography and pulmonary angiography 显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，： | 1 |
| 3 | Deep Venous Thrombosis with Suspected Pulmonary Embolism: Detection with Combined CT Venography and Pulmonary Angiography显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，2： | 1 |
| 4 | Deep venous thrombosis with suspected pulmonary embolism:detection with combined CT venography and pulmonary angiography显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，2： | 1 |
| 5 | Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: a prospective, randomized, controlled trial 显示文摘 | Altice FL Maru DS Bruce RD | 2007 | Clin Infect Dis2007，45，6： | 1 |
| 6 | Deep venous thrombosis with suspected pulmonary embolism: detection with combined CT venog- raphy and pulmonary angiography 显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，： | 1 |
| 7 | Deep venous thrombosis with suspected pulmonary embolism:detection with combined CT venography and pulmonary angiography显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，： | 1 |
| 8 | Deep venous thrombosis with suspected pulmonary embolism:detection with combined CT venography and pulmonary angiography显示文摘 | Katz DS Bruce DA | 2001 | Radiology2001，219，2： | 1 |
| 9 | Serum PARC/CCL-18 Concentrations and Health Outcomes in Chronic Obstructive Pulmonary Disease显示文摘 | Don DS Bruce EM Annelyse D | 2011 | Am J Respir Crit Care Med2011，183，9： | 1 |
| 10 | Deep venous thrombosis with suspected pulmonary embolism:detection with combined CT venography and pulmonary angiography 显示文摘 | LOUD PA KATZ DS BRUCE DA | 2001 | Radiology2001，219，2： | 1 |
| 11 | Evaluating the vulnerability of surface waters to antibiotic contamination from varying wastewater treatment plant discharges显示文摘 | Batt AL Bruce IB Aga DS | 2006 | Environ Pollut2006，142，： | 1 |
| 12 | Sleep architecture in children with idiopathic generalized epilepsy显示文摘 | Rama M Raj DS Bruce PH | 2005 | Epilepsia2005，46，： | 1 |
| 13 | Deep venous thrombosis with suspected pulmonary embolism:detection with combined CT venography and pulmonary angiography显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，2： | 1 |
| 14 | Relationship of HDL andcoronary heart disease to a commom amino acid polymonphismin the cholesteryl ester transfer protein in men with and withouthypertriglyceridemia显示文摘 | Bruce C Sharp DS Tall AR | 1998 | J lipid res1998，39，6： | 1 |
| 15 | Deep venous thrombosis with suspected pulmonary embolism: detection with combined CT venography and pulmonary angiographyl 显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，2： | 1 |
| 16 | Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor显示文摘 | Gary DS Bruce Keller AJ Kindy MS | 1998 | J Cereb Blood Flow Metab1998，18，12： | 1 |
| 17 | Combined CT venography and pulmonary angiography: a comprehensive review 显示文摘 | Katz DS Loud PA Bruce D | 2002 | Radiographics2002，22，： | 1 |
| 18 | Deep venous thrombosis with suspected pulmonary embolism: detection with combined CT venography and pulmonary angiography显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，2： | 1 |
| 19 | Deep venous thrombosis with suspected pulmonary embolism: detection with combined CT venography and pulmonary angiography显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，： | 1 |
| 20 | Deep venous thrombosis with suspected pulmonary embolism: detection with combined CT venography and pulmonary angiography 显示文摘 | Loud PA Katz DS Bruce DA | 2001 | Radiology2001，219，2： | 1 |
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