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	题名	作者	年代	出处	被引量
1	墨旱莲组分中组织蛋白酶K非活性位点抑制剂研究显示文摘组织蛋白酶K(CTSK)是抗骨质疏松药物的关键靶标。CTSK活性位点抑制剂能抑制胶原蛋白降解活性,同时抑制CTSK降解其他蛋白的水解活性,存在较大的不良反应,CTSK非活性位点(exosite)抑制剂具有抑制骨胶原降解活性且不影响活性位点(active site)的生物活性。本研究通过毕赤酵母表达系统表达出重组CTSK,进一步通过N端正丁基琼脂糖凝胶柱和SP-琼脂糖凝胶柱分离,得到高纯度有活性的重组CTSK。利用所得CTSK考察筛选了中药墨旱莲不同提取物及化学成分对CTSK的胶原降解活性和对CTSK与Z-FR-MCA底物结合的抑制作用,明确了墨旱莲的正丁醇部位为理想的潜在非活性位点活性部位,从中提取的墨旱莲皂苷IX为潜在的非活性位点抑制剂。	蒋益萍吴岩斌秦路平张巧艳辛海量 Dieter Bromme 薛黎明	2017	药学学报2017，52，6：	4
2	Responses of Human Cutaneous Afferents to CO2 Laser Stimuli Causing Pain 显示文摘	BROMM B JAHNKE M T TREEDE R D	1984	Exp Brain Res1984，55，：	1
3	High level expression and crystallization of recombinant human cathepsin S 显示文摘	Bromme D Mcgrath M E	1996	Protein Sci1996，5，4：	1
4	Apoptosis in the heart:when and why?显示文摘	Holtz J	1996	Mol Cell Biochem1996，，：	1
5	Estimation of single-evoked cerebral potentials by means of parametric modeling and kalman filtering显示文摘	Spreckelsen MV Bromm B	1988	IEEE Trans BME1988，35，：	1
6	Biochemical properties and regulation of cathepsin K activity 显示文摘	Lecaille F Bromme D Lalmanach G	2008	Biochimie2008，90，：	1
7	How best to fight that nasty itchfrom new insights into the neuroimmunological,neuroendocrine,a nd neurophysiological bases of pruritus to novel therapeuticapproaches显示文摘	Biro T Ko MC Bromm B	2005	Exp Dermatol2005，14，3：	1
8	Human cathepsin K cleaves native type Ⅰ and Ⅱ collagens at the N-terminal end of the triple helix显示文摘	Kafienah W Bromme D Buttle DJ		0，，：	1
9	The mlmber )f people with glaucoma worldwide in 2010 and 2020 显示文摘	Quigley HA Bromm AT	2006	Br J Ophthalmol2006，90，3：	1
10	How best to fight that nastyitch-from insights Into the neuroimmunological,neuroendocrine,and neurophysiological bases of pruritus to novel therapeutic approaches显示文摘	BIRO T KO MC BROMM B	2005	Exp Dermatol2005，14，6：	1
11	Neurophysiological Evaluation of Pain 显示文摘	BROMM B LORENZ J	1998	Electroencephalography and Clinical Neurophysiolo- gy1998，107，4：	1
12	Essential role for cathepsin S in MHC class Ⅱ-associated invariant chain processing and peptide loading显示文摘	Riese RJ Wolf PR Bromme D	1996	Immunity1996，4，4：	1
13	Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis 显示文摘	Hou W S Bromme D Zhao Y	1999	J Clin Invest1999，103，5：	1
14	Compari- son of statistical approaches for the analysis of proteome expression data of differentiating neural stem cells 显示文摘	Maurer M H Feldmann R E Bromme J O	2005	Journal of Proteome Research2005，4，1：	1
15	Pruritus circumscriptus sine ma- terial: a sequel of postzosteric neuralgia 显示文摘	Darsow U Lorenz J Bromm B	1996	Acta Derm Venereol1996，76，1：	1
16	Principal component analysis of pain-related cerebral potentials to mechanical and electrical stimulation in man显示文摘	Bromm B Scharein E	1982	Electroencephalogr Clin Neurophysiol1982，53，：	1
17	Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus显示文摘	Treede R Apkarian A Bromm B	2000	Pain2000，87，2：	1
18	How best to fight that nasty itchfrom new insights into the neuroim munological, neuroendocrine and neurophysiological bases of pruritus to novel therapeutic approaches 显示文摘	Biro T Ko MC Bromm B	2005	Exp Dermatol2005，14，3：	1
19	Therapeutic efficacy of 1α,25-dihydroxyvitamin D3 and calcium in osteopenic ovariectomized rats: evidence for a direct anabolic effect of lct, 25-dihydroxyvitamin D3 on bone显示文摘	Erben RG Bromm S Stangassinger M	1998	Endocrinology1998，139，：	1
20	Responses of human cutaneous afferents to CO2 laser stimuli causing pain 显示文摘	Bromm B Jahnke MT Treede RD	1984	Exp Brain Res1984，55，：	1

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