|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Yin and Yang of mesenchymal stem cells and aplastic anemia显示文摘Acquired aplastic anemia(AA) is a bone marrow failure syndrome characterized by peripheral cytopenias and bone marrow hypoplasia. It is ultimately fatal without treatment, most commonly from infection or hemorrhage. Current treatments focus on suppressing immune-mediated destruction of bone marrow stem cells or replacing hematopoietic stem cells(HSCs) by transplantation. Our incomplete understanding of the pathogenesis of AA has limited development of targeted treatment options. Mesenchymal stem cells(MSCs) play a vital role in HSC proliferation; they also modulate immune responses and maintain an environment supportive of hematopoiesis. Some of the observed clinical manifestations of AA can be explained by mesenchymal dysfunction. MSC infusions have been shown to be safe and may offer new approaches for the treatment of this disorder. Indeed, infusions of MSCs may help suppress auto-reactive, T-cell mediated HSC destruction and help restore an environment that supports hematopoiesis. Small pilot studies using MSCs as monotherapy or as adjuncts to HSC transplantation have been attempted as treatments for AA. Here we review the current understanding of the pathogenesis of AA and the function of MSCs, and suggest that MSCs should be a target for further research and clinical trials in this disorder. | Larisa Broglie David Margolis Jeffrey A Medin | 2017 | World Journal of Stem Cells2017，9，12： | 3 |
| 2 | Endoscopic dilation of complete oesophageal obstructionswith a combined antegrade-retrograde rendezvoustechnique显示文摘AIM: To investigate the combined antegraderetrograde endoscopic rendezvous technique for complete oesophageal obstruction and the swallowing outcome.METHODS: This single-centre case series includes consecutive patients who were unable to swallow due to complete oesophageal obstruction and underwent combined antegrade-retrograde endoscopic dilation(CARD) within the last 10 years. The patients' demographic characteristics, clinical parameters, endoscopic therapy, adverse events, and outcomes were obtained retrospectively. Technical success was defined as effective restoration of oesophageal patency. Swallowing success was defined as either percutaneous endoscopic gastrostomy(PEG)-tube independency and/or relevant improvement of oral food intake, as assessed by the functional oral intake scale(FOIS)(≥ level 3).RESULTS: The cohort consisted of six patients [five males; mean age 71 years(range, 54-74)]. All but one patient had undergone radiotherapy for head and neck or oesophageal cancer. Technical success was achieved in five out of six patients. After discharge, repeated dilations were performed in all five patients. During follow-up(median 27 mo, range, 2-115), three patients remained PEG-tube dependent. Three of four patients achieved relevant improvement of swallowing(two patients: FOIS 6, one patient: FOIS 7). One patient developed mediastinal emphysema following CARD, without a need for surgery.CONCLUSION: The CARD technique is safe and a viable alternative to high-risk blind antegrade dilation in patients with complete proximal oesophageal obstruction. Although only half of the patients remained PEG-tube independent, the majority improved their ability to swallow. | Reto Bertolini Christa Meyenberger Paul Martin Putora Franziska Albrecht Martina Anja Broglie Sandro J Stoeckli Michael Christian Sulz | 2016 | World Journal of Gastroenterology2016，22，7： | 3 |
| 3 | Estimation of Time to Maximum Rate Under Adiabatic Conditions(TMR_(ad)) Using Kinetic Parameters Derived From DSC-Investigation of Thermal Behavior of 3-Methyl-4-Nitrophenol显示文摘Kinetic parameters of the decomposition of hazardous chemicals can be applied for the estimation of their thermal behavior under any temperature profile.Presented paper describes the application of the advanced kinetic approach for the determination of the thermal behavior also under adiabatic conditions occurring e.g.in batch reactors in case of cooling failure.The kinetics of the decomposition of different samples(different manufacturers and batches) of 3-methyl-4-nitrophenol were investigated by conventional DSC in non-isothermal(few heating rates varying from 0.25 to 8.0K/min) and isothermal(range of 200~260℃) modes.The kinetic parameters obtained with AKTS-Thermokinetics Software were applied for calculating reaction rate and progress under different heating rates and temperatures and verified by comparing simulated and experimental signals.After application of the heat balance to compare the amount of heat generated during reaction and its removal from the system,the knowledge of reaction rate at any temperature profiles allowed the determination of the temperature increase due to the self-heating in adiabatic and pseudo-adiabatic conditions.Applied advanced kinetic approach allowed simulation the course of the Heat-Wait-Search(HWS) mode of operation of adiabatic calorimeters.The thermal safety diagram depicting dependence of Time to Maximum Rate(TMR) on the initial temperature was calculated and compared with the results of HWS experiments carried out in the system with Ф-factor amounting to 3.2.The influence of the Ф-factor and reaction progress reached at the end of the HWS monitoring on the TMR is discussed.Presented calculations clearly indicate that even very minor reaction progress reduces the TMRad of 24h characteristic for a sample with initial reaction progress amounting to zero.Described estimation method can be verified by just one HWS-ARC,or by one correctly chosen ISO-ARC run of reasonable duration by knowing in advance the dependence of the TMR on the initial temperature for any Ф-factor.Proposed procedure results in significant shortening of the measuring time compared to a safety hazard approach based on series of ARC experiments carried out at the beginning of a process safety evaluation. | Bertrand Roduit Patrick Folly Alexandre Sarbach Beat Berger Franz Brogli Francesco Mascarello Mischa Schwaninger Thomas Glarner Eberhard Irle Fritz Tobler Jacques Wiss Markus Luginbühl Craig Williams Pierre Reuse Francis Stoessel | 2011 | 化学推进剂与高分子材料2011，9，1： | 3 |
| 4 | Sur la refutation du theoreme de Bell显示文摘 | | 1974 | CRAS1974，278，： | 1 |
| 5 | Transgenic plants with enhanced resistance to the fungal pathogen Rhizoctonia solani显示文摘 | Broglie K Chet I Holliday M | 1991 | Science1991，254，5035： | 1 |
| 6 | La thermodynamique de la particule isolee显示文摘 | de Broglie L | 1961 | CRAS1961，，： | 1 |
| 7 | Transgenic plant with enhanced resistance to the fungal pathogen rhizoctonia solani显示文摘 | Broglie K Chet I Holliday M | 1991 | Science1991，254，： | 1 |
| 8 | Cytology of infection of35S-bean chitinase transgenic canola plants by Rhizoctonia solani:cytochemical aspects of chitin breakdown in vivo显示文摘 | Benhamou N Broglie K Chet I | 1993 | The Plant Jour-nal1993，4，2： | 1 |
| 9 | The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha) 显示文摘 | Schreiber SN Knutti D Brogli K | 2003 | J Biol Chem2003，278，11： | 1 |
| 10 | Chitinase and plant protection显示文摘 | BROGLIE K E | 1993 | Dev Plant Pathol1993，2，： | 1 |
| 11 | Modulation of pro-apoptotic(Bax) and anti-apoptotic (Bcl-2) gene expression in isolated porcine hepatocytes perfused within a radial-flow bioreactor after low-temperature storing显示文摘 | Mischiati C Puviani A C Brogli M | 2003 | Int J Artif Organs2003，26，2： | 1 |
| 12 | Biologic liver support: optimal cell source and mass显示文摘 | Morsiani E Brogli M Galavotti D | 2002 | Int J Artif Organs2002，25，10： | 1 |
| 13 | Nucleotide se-quences of two pea cDNA clones encoding the small sub-unit of ribulose 1,5-bisphosphate carboxylase and the ma-jor chlorophyll a/b binding thylakoid polypeptide显示文摘 | Coruzzi G Broglie R Cashmore A R | 1983 | BiolChem1983，258，： | 1 |
| 14 | Chitinase and plant protection显示文摘 | BROGLIE K E | 1993 | Rev Plant Pathol1993，2，： | 1 |
| 15 | Transgenic plant with enhanced resistance to the fungal pathogen Rhizoctonia solani显示文摘 | Broglie K E Chet I Holliday M | 1991 | Science1991，254，： | 1 |
| 16 | Impact of thrombocytopenia on outcome of patients admitted to ICU for severe community-acquired pneumonia显示文摘 | Brogly N Devos P Boussekey N | 2007 | J Infect2007，55，2： | 1 |
| 17 | Cytology of infection of 35S-bean chitinase transgetic canola plants by Rhizoctonia solani:cytochemical aspects of chitin breakdown in vivo显示文摘 | Benhamou NK Broglie IC Broglie R | 1993 | Plant J1993，4，： | 1 |
| 18 | Molecular characterization of a novel β-1,3-glucanase related to mycoparasitism of Trichoderma harzianum 显示文摘 | Cohen-Kupiec R Broglie K B Friesem D | 1999 | Gene1999，226，： | 1 |
| 19 | How to diagnose sinus fungus balls in the paranasal sinus? An analysis of an institution's cases from January 1999 to December 2006显示文摘 | Broglie MA Tinguely M Holzman D | 2009 | Rhinology2009，47，4： | 1 |
| 20 | The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor alpha( ERR alpha) 显示文摘 | SCHREIBER S N KNUTYI D BROGLI K | 2003 | Biol Chem2003，278，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员