|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ontogenesis of sleep in human prematrues after 32 weeks of conceptional age 显示文摘 | Dreyfus - Brisac C | 1970 | Dev Psychobiol1970，3，2： | 1 |
| 2 | Comparison between the ef fects of angiotensin-converting-enzyme inhibitors and angiotensin Ⅱ antagonists显示文摘 | Asmar R Makonna O Brisac AM | 1998 | Therapie1998，53，3： | 1 |
| 3 | Differential effects of tyrosine kinase inhibitors on contraction and relaxation of the aortas of normotensive and hypertensive rats显示文摘 | Zerrouk A Auguet M Dabire H Brisac AM Safar M Chabrier PE | 1999 | Eur J Pharmacol1999，374，1： | 1 |
| 4 | Assessment of Arterial Distensibility by Automatic Pulse Wave Velocity Measurement: Validation and Clinical Application Studies显示文摘 | Roland Asmar Athanase Benetos Jirar Topouchian Pierre Laurent Bruno Pannier Anne-Marie Brisac Ralph Target Bernard I. Levy | 1995 | Hypertension1995，，3： | 1 |
| 5 | Early phosphati- dylinositol 3 - kinase/Akt pathway activation limits poliovir- us- induced JNK- mediated cell death 显示文摘 | Autret A Martin - Latil S Brisac C | 2008 | J Viro12008，82，7： | 1 |
| 6 | A Genetic Screen Identifies Interferon-α Effector Genes Required to Suppress Hepatitis C Virus Replication显示文摘 | Dahlene N. Fusco Cynthia Brisac Sinu P. John Yi–Wen Huang Christopher R. Chin Tiao Xie Hong Zhao Nikolaus Jilg Leiliang Zhang Stephane Chevaliez Daniel Wambua Wenyu Lin Lee Peng Raymond T. Chung Abraham L. Brass | 2013 | Gastroenterology2013，，7： | 1 |
| 7 | Reference values for clinic pulse pressure in a nonselected population显示文摘 | Asmar R Vol S Brisac AM | 2001 | Am J Hypertens2001，14，： | 1 |
| 8 | Apoptotic signaling cascades operating in poliovirus-in- fected ceils 显示文摘 | BLONDEL B AUTRET A BRISAC C | 2009 | Front Biosci2009，14，： | 1 |
| 9 | Apoptotic signaling cascades operating in poliovirus-infected cells显示文摘 | Blondel B Autret A Brisac C | 2009 | Front Biosci2009，1，14： | 1 |
| 10 | Comparison between the effects of angiotensin converting enzyme inhibitors and angioten Ⅱ antagonists显示文摘 | Asmar R Makonna O Brisac AM | 1998 | Therapie1998，53，3： | 1 |
| 11 | Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C显示文摘AIM To characterize the role of apolipoprotein B100(apoB 100) in hepatitis C viral(HCV) infection. METHODS In this study, we utilize a gene editing tool, transcription activator-like effector nucleases(TALENs), to generate human hepatoma cells with a stable genetic deletion of APOB to assess of apoB in HCV. Using infectious cell culture-competent HCV, viral pseudoparticles, replicon models, and lipidomic analysis we determined the contribution of apoB to each step of the viral lifecycle. We further studied the effect of mipomersen, an FDAapproved antisense inhibitor of apoB 100, on HCV using in vitro cell-culture competent HCV and determined itsimpact on viral infectivity with the TCID50 method. RESULTS We found that apo B100 is indispensable for HCV infection. Using the JFH-1 fully infectious cell-culture competent virus in Huh 7 hepatoma cells with TALENmediated gene deletion of apoB(APOB KO), we found a significant reduction in HCV RNA and protein levels following infection. Pseudoparticle and replicon models demonstrated that apo B did not play a role in HCV entry or replication. However, the virus produced by APOB KO cells had significantly diminished infectivity as measured by the TCID-50 method compared to wildtype virus. Lipidomic analysis demonstrated that these virions have a fundamentally altered lipidome, with complete depletion of cholesterol esters. We further demonstrate that inhibition of apoB using mipomersen, an FDA-approved anti-sense oligonucleotide, results in a potent anti-HCV effect and significantly reduces the infectivity of the virus. CONCLUSION Apo B is required for the generation of fully infectious HCV virions, and inhibition of apo B with mipomersen blocks HCV. Targeting lipid metabolic pathways to impair viral infectivity represents a novel host targeted strategy to inhibit HCV. | Esperance AK Schaefer James Meixiong Christina Mark Amy Deik Daniel L Motola Dahlene Fusco Andrew Yang Cynthia Brisac Shadi Salloum Wenyu Lin Clary B Clish Lee F Peng Raymond T Chung | 2016 | World Journal of Gastroenterology2016，22，45： | 1 |
| 12 | 阿伯丁孔雀视觉艺术中心显示文摘该项目中至关重要的策略是将孔雀视觉艺术新建筑同四周的阳台花园天衣无缝地融合在一起. | Cécile Brisac Edgar Gonzalez | 2011 | 设计家2011，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员