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| 1 | Single-cell approaches to investigate B cells and antibodies in autoimmune neurological disorders显示文摘Autoimmune neurological disorders,including neuromyelitis optica spectrum disorder,anti-N-methyl-D-aspartate receptor encephalitis,anti-MOG antibody-associated disorders,and myasthenia gravis,are clearly defined by the presence of autoantibodies against neurological antigens.Although these autoantibodies have been heavily studied for their biological activities,given the heterogeneity of polyclonal patient samples,the characteristics of a single antibody cannot be definitively assigned.This review details the findings of polyclonal serum and CSF studies and then explores the advances made by single-cell technologies to the field of antibody-mediated neurological disorders.High-resolution single-cell methods have revealed abnormalities in the tolerance mechanisms of several disorders and provided further insight into the B cells responsible for autoantibody production.Ultimately,several factors,including epitope specificity and binding affinity,finely regulate the pathogenic potential of an autoantibody,and a deeper appreciation of these factors may progress the development of targeted immunotherapies for patients.Access options. | Alicia Zou Sudarshini Ramanathan Russell C.Dale Fabienne Brilot | 2021 | Cellular & Molecular Immunology2021，18，2： | 4 |
| 2 | Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome 显示文摘 | Brilot F Merheb V Ding A | 2011 | Neu- rology2011，17，4： | 1 |
| 3 | Autoim- mune encephalitis:recent updates and emerging challenges 显示文摘 | Ramanathan S Mohammad SS Brilot F | 2014 | J Clin Neurosci2014，21，5： | 1 |
| 4 | NK cells interactions with dendritic cells shape innate and adaptive immunity显示文摘 | Brilot F Strowig T Munz C | 2008 | Front Biosci2008，13，17： | 1 |
| 5 | Thymic neuroendocrineself-antigens role in T-cell development and central T-cell self-tolerance显示文摘 | GEENEN V MARTENS H BRILOT F | 2000 | Ann N Y Acad Sci2000，91，7： | 1 |
| 6 | Role of the thymus in the development of tolerance and autoimmunity towards the neuroendocrine system显示文摘 | Eenen V Brilot F | 2003 | Ann N Y Acad Sci2003，992，： | 1 |
| 7 | New players in the physiopathology of water metabolism:the aquaporins显示文摘 | Pequeux C Brilot F Martens H | 1999 | Rev Med Liege1999，54，11： | 1 |
| 8 | Noncytotoxic functions of NK cells:direct pathogen restriction and assistance to adaptive immunity显示文摘 | Strowing T Brilot F Muünz C | | 0，，： | 1 |
| 9 | Autoimmune en- cephalitis : recent updates and emerging challenges显示文摘 | Ramanathan S Mohammad SS Brilot F | 2014 | J Clin Neu- rosci2014，21，： | 1 |
| 10 | Noncytotoxicfunctions of NK cells : direct pathogen restriction andassistance to adaptive immunity 显示文摘 | STROWIG T BRILOT F MtlNZ C | 2008 | J Immunol2008，180，12： | 1 |
| 11 | Noncytotoxic functions of NK cells direct pathogen restriction and assistance to adaptive immunity 显示文摘 | Strowig T Brilot F Munz C | 2008 | Immu- nol2008，180，12： | 1 |
| 12 | Cerebrospinal fluid neopterin in paediatrie neurology: a marker of active central nervous system inflammation显示文摘 | Dale tlC Brilot F Fagan E | 2009 | Dev Med Child Neurol2009，51，4： | 1 |
| 13 | Pediatric central nervous system inflammatory demyelination: acute disseminated encephalomyelitis, clinically isolated syndromes, neuromyelitis optica, and multiple sclerosis显示文摘 | Dale RC Brilot F Banwell B | 2009 | Curt Opin Nettrol2009，22，3： | 1 |
| 14 | Antibody responses to EBV and native MOG in pediatric inflammatory demyelinating CNS diseases 显示文摘 | Selter RC Brilot F Grummel V | 2010 | Neurology2010，74，5： | 1 |
| 15 | Autoimmune encephalitis: Recent updates and emerging challenges显示文摘 | Ramanathan S Mohammad SS Brilot F | 2014 | J Clin Neurosci2014，21，5： | 1 |
| 16 | Antibodies to native my- elin oligodendrocyte glyeoprotein in children with inflammatoryemyelinating central nervous system disease显示文摘 | Brilot F Dale RC Selter RC | 2009 | Ann Neurol2009，66，： | 1 |
| 17 | Noncytotoxic functions of NK cells direct pathogen restriction and assistance to adaptive immunity 显示文摘 | Strowig T Brilot F Miinz C | 2008 | J hnmunol2008，180，： | 1 |
| 18 | Autoimmune epilepsy in children: case series and proposed guidelines for identification 显示文摘 | Suleiman J Brilot F Lang B | 2013 | Epilepsia2013，54，6： | 1 |
| 19 | NMDA receptor antibodies in pediatric dyskinetic encephalitis lethargi- ca显示文摘 | Dale RC Irani SR Brilot F | 2009 | AnnNeurol2009，66，： | 1 |
| 20 | Noncytotoxic functions of NK cells:direct pathogen restriction and assistance to adaptive immunity显示文摘 | Strowing T Brilot F Münz C | 2008 | J Immunol2008，180，： | 1 |
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