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您的检索式：作者名="Brigitte LEMYRE"
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| 1 | Do intra-operative fluids influence the need for post-operative cardiotropic support after a PDA ligation?显示文摘Objective To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic stability.Methods We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus(PDA) ligation in one NICU between 2001 and 2007.The primary outcome was the need for cardiotropic support within 24 hrs of ligation.Results Twenty-seven infants(28%) required post-operative cardiotropic support.The amount of intra-operative fluids varied between 0 and 50.4 mL/kg(median:10.2 mL/kg).No intra-operative fluid was recorded in 26 patients.Fluids were not associated with the need for post-operative cardiotropic support(P=0.10).Using a multivariate logistic regression model,age at ligation,weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic support.Conclusions Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support.A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population. | Brigitte LEMYRE 刘玲 Gregory Paul MOORE Sarah Linda LAWRENCE Nicholas J.BARROWMAN | 2011 | 中国当代儿科杂志2011，13，1： | 2 |
| 2 | 肌松剂在早产儿非急诊气管插管前的应用显示文摘目的探讨肌松剂-司可林在早产儿(<34周)非急诊气管插管前应用的安全性和疗效。方法将2007年1-7月在加拿大渥太华大学附属渥太华总医院和东安大略省儿童医院NICU行非急诊气管插管的早产儿,在共同应用芬太尼和阿托品的基础上,分为肌松剂组(A组,予阿托品、芬太尼,加用司可林);非肌松剂组(B组,仅用阿托品、芬太尼)。根据统一的气管插管程序,比较一次插管成功率、插管的总次数、插管人水平、Goldberg评分及不良反应。采用t检验和χ2检验行统计学分析。结果共44例患儿纳入研究,A组25例,B组19例,2组一般情况无统计学差异。A组一次插管成功率为56.0%(14例),B组为21.1%(4例),2组比较具有统计学差异(P<0.05)。A组平均插管次数[(1.8±1.3)次]低于B组[(2.5±1.3)次],A组Goldberg评分[(4.3±2.0)分]低于B组[(4.7±1.8)分],A组口鼻腔出血例数[5例(20.0%)]多于B组[2例(10.5%)],A组心动过缓(心率<100次/min)者[6例(24.0%)]少于B组[6例(31.6%)],A组氧饱和度<80%者[16例(64.0%)]少于B组[15例(78.9%)],A组皮囊加压给氧困难者[3例(12.0%)]少于B组[6例(31.6%)],但2组比较均无统计学差异(Pa>0.05)。结论阿托品、芬太尼、司可林联合用药,安全可靠,能提高一次插管成功率,避免反复插管引起的声门损伤,有利于年轻医师快速掌握气管插管术。 | 程锐 Brigitte Lemyre | 2009 | 实用儿科临床杂志2009，24，24： | 1 |
| 3 | A trial comparing noninvasive ventilation strategies in preterm infants显示文摘 | Haresh Kirpalani David Millar Brigitte Lemyre | 2013 | The New England Journal of Medicine2013，369，7： | 1 |
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