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7篇 您的检索式:作者名="Brian CW"
    题名 作者 年代 出处 被引量
1A microsatellite- based genetic linkage map for channel catfish(Ictalurus punctatus) 显示文摘Geoffrey CW Brian G B Danny JN 2001Genetics2001,158,:1
2Oat germination characteristeristics differ among genotypes, seed sizes, and osmotic potentials显示文摘Christian JW Jeffery CW Araon KM Brian GR Steven JS 2000Crop Science2000,45,:1
3Non-compaction of the Ventricular Myocardium显示文摘Brian CW Vijay DS Kevin MM 2004Circulation2004,109,24:1
4Pentration enhancers显示文摘Adrian CW Brian WB 2004Advanced Drug Delivery Reviews2004,56,5:1
5Malignant syndrome presenting as fever of unknown origin in the elderly显示文摘Hall Ryan CW Appleby Brian Hall Richard CW 2005Southern Med J2005,98,:1
6Malignantsyndrome presenting as fever of unknown origin in the elderly 显示文摘Hall Ryan CW Appleby Brian Hall Richard CW 2005Southern medical journal2005,98,:1
7Time of infliximab therapy initiation and dose escalation in Crohn's disease显示文摘AIM:To determine if early initiation of anti-tumor necrosis factor therapy affects the need for dose escalation.METHODS:This was a retrospective review of patients receiving infliximab therapy for Crohn’s disease(CD)at two outpatient gastroenterology clinics during July2009 to October 2010.All patients included in the study were biologic agent na?ve and had moderate to severe CD(Harvey Bradshaw index>8).Patients were divided into groups based on length of time between diagnosis to therapy initiation and concurrent immunosuppressant therapy.Kaplan-Meier survival analysis was used to compare the time to dose escalation for the four groups.RESULTS:There were 68 patients,51% female and 49% male,with an average age at diagnosis of 24.7±11.9 years.The average age at infliximab initiation was 34.8±14.8 years.Of the 68 patients,19%initiated inflixiamb within 2 years of diagnosis,and 51%had concurrent immunosuppressant therapy at the time of therapy initiation.Fifty percent of patients required dose escalation and the median time from therapy initiation to dose escalation was 10 mo(interquartile range:5.3-14.8).There was a statistically significant higher probability of requiring dose esclataion in patients who initiated biologic therapy within 2 years of diagnosis,without concurrent immunosuppressant therapy(P<0.01).CONCLUSION:Those who receive infliximab within 2years of CD diagnosis require more intense immunosuppressant therapy than those who received infliximab later.Mindy CW Lam Terry Lee Kenneth Atkinson Brian Bressler 2014World Journal of Gastroenterology2014,20,1:0
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