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| 1 | Producer Services in the Urban Core and Suburbs of Phoenix Arizona 显示文摘 | Breandan O hUallachain Timothy F Leslie | 2007 | Urban Studies2007，44，8： | 1 |
| 2 | Producer Services in the Uroan Core and Suburbs of Phoenix Arizona显示文摘 | Breandan O hUallachain Timothy F.Leslie | | 0，，44： | 1 |
| 3 | The Identification of Industrial Complexes显示文摘 | Breandan O hUallachain | 1984 | Annals of the Association of American Geographers1984，，3： | 1 |
| 4 | Producer Services in the Urban Core and Suburbs of Phoenix Afizona显示文摘 | Breandan O hUallachain Timothy F Leslie | 2007 | Urban Studies2007，，： | 1 |
| 5 | Producer Services in the Urban Core and Suburbs of Phoenix Arizona显示文摘 | Breandan O hUallachain Timothy F Leslie | | 0，，： | 1 |
| 6 | Producer Services in the Urban Core and Suburbs of Phoenix Arizona显示文摘 | Breandan O hUallachain Timothy F Leslie | 2007 | Urban Studies2007，44，8： | 1 |
| 7 | Effect of neuroprotectivecocktails on hippocampal neuron death in an in vitro modle of cerebral ischemia显示文摘 | Robert P Breandan S | 2001 | J Neurosurgical Anesthesiology2001，13，1： | 1 |
| 8 | The Identification of Industrial Complexes显示文摘 | Breandan O | 1984 | Annals of the association of American Geographers1984，74，3： | 1 |
| 9 | Effect of neuroprotective cocktails on hippocampal neuron death in an invitro model of cerebral ischemia 显示文摘 | Richard Liniger Robert Popovic Breandan Sullivan | 2001 | J Neurosurg Anesthesiology2001，13，1： | 1 |
| 10 | 一种用二氧六环制备紫杉醇冻干制剂的简易方法显示文摘第二代紫杉醇卡巴他赛(CTX)由于对P-gp糖蛋白的亲和力较低,具有不易产生耐药性等优点,被成功地应用于治疗耐药性前列腺癌的临床治疗中.由于CTX的疏水性较高,临床使用的制剂是由液体表面活性剂Tween-80和乙醇组成的(Tween-80与CTX的质量比为27:1).而Tween-80可能在血液中导致溶血问题,引起过敏反应.在此工作中,我们报道了一种只用少量表面活性剂(pluronic F127与CTX的质量比为3:1)的冻干CTX的制剂:CTX和Pluronic F127一起溶解在由水和1,4-二恶烷(两种常用的冷冻干燥溶剂)组成的混合溶剂系统中制成的冻干粉.胶束状态下的溶剂系统可以经过无菌过滤膜达到除菌效果,结果表明在5%和高于60%的1,4-二恶烷浓度下通过过滤才能达到理想的过滤效果.冻干CTX制剂和重溶胶束的特性取决于共溶剂/溶剂比和F127与CTX的比例,并且能够通过调整比例来调节纳米颗粒的尺寸.用60%的1,4-二恶烷溶解质量比为3:1的F127/CTX所得的冻干CTX产物,重溶后的胶束在水相中能稳定至少三小时.在对小鼠进行静脉给药后,血液中的CTX浓度不依赖于胶束的粒径大小,并且血液代谢和纯Tween-80制剂类似.小鼠抗肿瘤实验表明小鼠体内MIA Paca-2肿瘤抑制功效与Tween-80制剂相似.综上所述,此工作报道了一种简单的冻干方法用于制备紫杉醇药物制剂,具有制备方法高效和表面活性剂添加量低等优点. | 孙勃旸 邵帅 Sanjana Ghosh 黎杰鑫 王晓洁 李昌宁 Breandan Quinn Paschalis Alexandridis Jonathan F.Lovell 张育淼 | 2023 | Science China Materials2023，66，6： | 0 |
| 11 | Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel显示文摘Photodynamic therapy(PDT)is a non-invasive tumor ablation modality that can be enhanced in combination with concurrent chemotherapy.Previously,we demonstrated that liposomes containing a bilayer-anchored photosensitizer(porphyrin-phospholipid;PoP)can be loaded with drugs in their aqueous core to improve drug delivery and tumor ablation upon target tissue irradiation with red-light.In the present work,we demonstrate that this concept can be extended to drugs loaded within the hydrophobic bilayer of liposomes.Cabazitaxel(CTX)is a potent second generation taxane anti-cancer drug that was loaded in the bilayer of liposomes also containing 0.1 molar%PoP,generating CTX-loaded PoP liposomes(CTX-PoP-Lip).CTX-PoP-Lip showed unilamellar vesicle morphology,and exhibited integrity in storage and serum,while maintaining drug stability under laser irradiation.In vitro cell killing evaluation showed that red-light laser irradiation induced cytotoxicity in cells incubated with CTX-PoP-Lip,compared to control treatments.In vivo pharmacokinetic analysis revealed that following intravenous administration to mice,CTX and PoP exhibited somewhat altered circulation profiles,suggesting that the CTX may have exchanged with serum factors in blood.Nevertheless,when a single treatment of CTX-PoP-Lip with laser irradiation was administered to mice bearing human MIA Paca-2 tumors,tumors were effectively ablated whereas the equivalent chemotherapy and PDT monotherapies were ineffective.These results demonstrate the versatility of liposome delivery systems for achieving tumor ablation with chemophototherapy. | Boyang Sun Sanjana Ghosh Xuedan He Wei-Chiao Huang Breandan Quinn Meiling Tian Dushyant Jahagirdar Moustafa T.Mabrouk Joaquin Ortega Yumiao Zhang Shuai Shao Jonathan F.Lovell | 2022 | Nano Research2022，15，5： | 0 |
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