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| 1 | Arsenic trioxide promotes mitochondrial DNA mutation and cell apoptosis in primary APL cells and NB4 cell lines显示文摘This study aimed to investigate the effects of arsenic trioxide(As2O3) on the mitochondrial DNA(mtDNA) of acute promyelocytic leukemia(APL) cells.The NB4 cell line was treated with 2.0 μmol/L As2O3 in vitro,and the primary APL cells were treated with 2.0 μmol/L As2O3 in vitro and 0.16 mg kg-1 d-1 As2O3 in vivo.The mitochondrial DNA of all the cells above was amplified by PCR,directly sequenced and analyzed by Sequence Navigatore and Factura software.The apoptosis rates were assayed by flow cytometry.Mitochondrial DNA mutation in the D-loop region was found in NB4 and APL cells before As2O3 use,but the mutation spots were remarkably increased after As2O3 treatment,which was positively correlated to the rates of cellular apoptosis,the correlation coefficient:rNB4-As2O3=0.973818,and rAPL-As2O3=0.934703.The mutation types include transition,transversion,codon insertion or deletion,and the mutation spots in all samples were not constant and regular.It is revealed that As2O3 aggravates mtDNA mutation in the D-loop region of acute promyelocytic leukemia cells both in vitro and in vivo.Mitochondrial DNA might be one of the targets of As2O3 in APL treatment. | MENG Ran1,ZHOU Jin2,SUI Meng3,LI ZhiYong4,FENG GuoSheng1 & YANG BaoFeng2 1 Division of Neurology,the Ninth Clinical Medical College of Beijing University(Shijitan Hospital),Beijing 100038,China 2 The First Hospital of Harbin Medical University,Harbin 150001,China 3 Management Information System,University of International Business and Economics,Beijing 100029,China 4 Department of Radiology,Cambridge University Hospitals NHS Foundation Trust Box 219 Level 5,Addenbrooke’s Hospital Cambridge CB2 0QQ,UK | 2010 | Science China(Life Sciences)2010，53，1： | 10 |
| 2 | Climate Changes in the 21st Century over the Asia-Pacific Region Simulated by the NCAR CSM and PCM显示文摘The Climate System Model (CSM) and the Parallel Climate Model (PCM), two coupled global climate models without flux adjustments recently developed at NCAR, were used to simulate the 20th century climate using historical greenhouse gas and sulfate aerosol forcing. These simulations were extended through the 21st century under two newly developed scenarios, a business-as-usual case (BAU, CO2≈710 ppmv in 2100) and a CO2 stabilization case (STA550, CO2≈540 ppmv in 2100). The simulated changes in temperature, precipitation, and soil moisture over the Asia-Pacific region (10°-60°N, 55°-155°) are analyzed, with a focus on the East Asian summer monsoon rainfall and climate changes over the upper reaches of the Yangtze River. Under the BAU scenario, both the models produce surface warming of about 3-5℃ in winter and 2-3℃ in summer over most Asia. Under the STA550 scenario, the warming is reduced by 0.5-1.0℃ in winter and by 0.5℃ in summer. The warming is fairly uniform at the low latitudes and does not induce significant changes in the zonal mean Hadley circulation over the Asia-Pacific do- main While the regional precipitation changes from single CSM integrations are noisy, the PCM ensemble mean precipitation shows 10%-30% increases north of ~ 30°N and~10% decreases south of ~ 30°N over the Asia-Pacific region in winter and 10%-20% increases in summer precipitation over most of the region. Soil moisture changes are small over most Asia The CSM single simulation suggests a 30% increase in river runoff into the Three Gorges Dam, but the PCM ensemble simulations show small changes in the | Aiguo Dai, G.A. Meehl, W.M. Washington, and T.M.L. Wigley National Center for Atmospheric Research P.O. Box 3000, Boulder, CO 80307 ) Email: adai@ ucar. edu The National Center for Atmospheric Research is sponsored by the U S National Science Foundation. | 2001 | Advances in Atmospheric Sciences2001，18，5： | 9 |
| 3 | PANSYSTEMS LOGIC:A NEW LOGIC FRAMEWORK FOR ARTIFICIAL INTELLIGENCE显示文摘Zan Tingquan and Wu Xuemou, Pansystems logic: a new logic fra-mework for AI.In this artic1e, we take a step towards providing a new logic fra-mework as a basis for human and artificial intelligence.We unite logic,epistemology, cognitive science, methodology and s ystems sciences tostudy cognitive processes and forms of thought and try to construct anew logic framework by use of pansystems metllodology.The new logicframework is called pansystems Logic.Included are:(1)propose the concepts of generalized. subjects and generalizedobjects, articulate the pansystems observocontrol relativity principle asa new model of cognitive foundations for artifitial intelligence.(2)present fifteen layer-parts of artifitial intelligence researchfrom the new view, i.e.AI concerns with five aspects of man, things,the relations between man and things, artificial systems, the relations be-tween the former three and the latter one,which should be studied fromthree levels of philosophical, mathematical and technical researches. | Zan Tingquan Li Yongli(Northwest Development Institute, Lanzhou University, Lanzhou 730000,Gansu,People’s Republic of China)Wu Xuemou(China Digital Engineering Institute,P。O。Box 74223, Wuchang 430074,Hubei,People’s Republic of China) | 1991 | 天水师范学院学报1991，11，4： | 4 |
| 4 | The reconstruction and interpretations of lake status at 6 ka and 18 ka B.P.in inland mainland Asia显示文摘By means of survey of literature through compilations of sedimentological, biogeological and geomorphologic data, the inland lake level changes in arid or semi arid mainland Asia at 6 and 18 ka B.P. have been reconstructed. The results showed that the lakes from western and northwestern Asia were characterized by very high water levels at 18 ka B.P., but low or intermediate water stands at 6 ka B.P. The high lake level in this region was associated with the southward displacement of westerlies, therefore, the extent of the high lake stand indicated the southern flank of westerlies during the glaciation. Conversely, the lakes from the eastern and southern Asia registered comparative low levels at 18 ka B.P. and significantly high one at 6 ka B.P. The lowering of lake level at 18 ka B.P. was caused by the weakened summer monsoon and the high lake level at 6 ka B.P. by the enhanced summer monsoon induced by the enlarged thermal contrast between land and ocean. The extent of high lake levels indicated the northern boundary of monsoon expansion. Between the above two regions, there is a climatic transitional zone in the Central Asia where the lake behavior was close to that in southeastern Asia at 6 ka B.P. but became similar to that in northwestern Asia at 18 ka B.P. Thus this zone became a transitional sector from the monsoon to the westerlies. | QIN Boqiang 1, SHI Yafeng 1 and YU Ge 2, 3 1. Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing 210008, China 2. Dynamic Palaeoclimatology, Lund University, PO Box 117, S 221 00, Lund, Sweden 3. Department of | 1998 | Chinese Science Bulletin1998，43，14： | 2 |
| 5 | Multifaetor experimental de- sign for exploring response surface 显示文摘 | Box G E P Hunter J S | 1957 | Annals of Mathematical Statistics1957，28，： | 1 |
| 6 | Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck显示文摘 | Luangdilok S Box C Patterson L Court W Harrington K Pitkin L | 2007 | Cancer Res2007，67，16： | 1 |
| 7 | Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis eleguns显示文摘 | ZHANG S O BOX A C XU N | 2010 | Proceeding of the National Academy of Sciences of the United States of America2010，107，10： | 1 |
| 8 | MAPK and PI3K signalling differentially regulate angiogenic and lymphangiogenic cytokine secretion in squamous cell carcinoma of the head and neck显示文摘 | Luangdilok S Box C Harrington K | 2011 | EurJCancer2011，47，4： | 1 |
| 9 | Protocol:A simple phenol-based method for 96-well extraction of high quality RNA from Arabidopsis显示文摘 | Mathew S Box Vincent Coustham Caroline Dean | | 0，，： | 1 |
| 10 | Late glacial to Holocene benthic foraminifera in the Marmara Sea:implications for Black Sea-Mediterranean Sea connections following the last deglaciation显示文摘 | Kaminski M.A Aksu A Box M Hiscott R.N Filipescu S AlSalameen M | | 0，，： | 1 |
| 11 | Minimally invasive management of upper tract malignancies: renal cell and transitional cell carcinoma显示文摘 | Box G N Lehman D S Landman J | 2008 | Urol Clin North Am2008，35，3： | 1 |
| 12 | Genetic and dietary regu- lation of lipid droplet expansion in Caenorhabditis elegans显示文摘 | Zhang S O Box A C Xu N | 2010 | Proc Natl Acad Sci U S A2010，107，10： | 1 |
| 13 | The effect of Marek's disease vaccination on the immunization of day-old chicks against New- castle disease, using B1 and oil emusionvaccine显示文摘 | Box P G I G S Furminger W W Robertson etal | 1976 | Avian Pathol1976，5，： | 1 |
| 14 | Split-plot Designs for Robust Product Experimentation显示文摘 | Box GEP Jones S | 1992 | Journal of Applied Statistics1992，19，： | 1 |
| 15 | MAPK and PI3K signalling differentially regulate angiogenic and lympha-ngiogenic cytokine secretion in squamous cell carcinoma of the head and neck显示文摘 | Luangdilok S Box C Harrington K | | 0，，04： | 1 |
| 16 | Split-plot designs for robust product experimentation显示文摘 | BOX G JONES S | 1992 | Journal of Applied Statistics1992，19，1： | 1 |
| 17 | Changes in Soil Solution Cu and Zn Following Application of Alkaline Stab ilised Sewage Sludge and GammaIrradiation显示文摘INTRODUCTIONThesoilsolutionisanopenaqueoussystemwheremanyofthesoil’schemicalandbiologicaltransformationsoccur,plantrootsabso... | YAN WEIDONG 1, LUO YONGMING 2 and P. CHRISTIE 2 1 Institute of Soil Science, the Chinese Academy of Sciences, P.O Box 821, Nanjing 210008 (China) 2 Agricultural and Environmental Science Department, the Queen’s University of Belfast, Ne | 1998 | Pedosphere1998，8，2： | 1 |
| 18 | Antioxidant response of the bivalve Pinna nobilis colonised by invasive red macroalgae Lophocladia lallemandii显示文摘 | Box A Sureda A Deudero S | 2009 | Comparative Biochemistry and Physiology2009，149，： | 1 |
| 19 | Root characteristics and hormone activity of wheat in responses to hypoxia and ethylene显示文摘 | HUANG B JOHNSON J W BOX J E NESMITH D S | 1997 | Crop Sciences1997，37，3： | 1 |
| 20 | The 2^k-p fractional factorial designs 显示文摘 | Box G E P Hunter J S | 1961 | Technometrics1961，，： | 1 |
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