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| 1 | Proliferation, apoptosis, and survivin expression in keratinoeytic neoplasms and hyperplasias显示文摘 | Bowen A R Hanks A N Murphy K J etal | 2004 | Am J Dermatopathol2004，26，3： | 1 |
| 2 | Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome显示文摘 | Dharap A Bowen K Place R | | 0，，： | 1 |
| 3 | Transient focal ischemia in- duces extensive temporal changes in rat cerebral microRNAome 显示文摘 | Dharap A Bowen K Place R | 2009 | J Cereb Blood Flow Metab2009，29，： | 1 |
| 4 | Novel processing routes to ultrafine grained steel显示文摘 | Ibraheem A K Priestner R Bowen J R | 2001 | Ironmaking and Steelmaking2001，28，2： | 1 |
| 5 | PTEN loss induces epithelialmesenchymal transition in human colon cancer cells显示文摘 | Bowen K A Doan H Q Zhou B P | 2009 | Anticaneer Res2009，29，11： | 1 |
| 6 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 7 | Novel processing routes to ultrafine-grained steel显示文摘 | Ibraheem A K Priestner R Bowen J R | 2001 | Ironmaking and Steelmaking2001，28，2： | 1 |
| 8 | Transient focal schemia induces extensive temporal changes in rat cere- bral MicroRNAome 显示文摘 | Dharap A Bowen K Place R | 2009 | J Cereb Blood Flow Metab2009，29，4： | 1 |
| 9 | Transient focal is- chemia induces extensive temporal changes in rat cerebral microRNAome显示文摘 | Dharap A Bowen K Place R | 2009 | J Cereb Blood Flow Metab2009，29，4： | 1 |
| 10 | Biological nitrogen fixition in tree in agroecosystem 显示文摘 | Sanso S K A Bowen Go sanginga N | 1992 | Plant and Soil1992，141，： | 1 |
| 11 | Analyses of expressed sequence tags from apple显示文摘 | NEWCOMB R D CROWHURST R N GLEAVE A P RIKKERINK E H A ALLAN A C BEUNING L L BOWEN J H GERA E JAMIESON K R JANSSEN B J LAING W A MCARTNEY S NAIN B ROSS G S SNOWDEN K C SOULEYRE E J F WALTON E F YAUK Y K | 2006 | Plant Physiology2006，141，： | 1 |
| 12 | Plastic bronchitis:large,branching,mucoid bronchial casts in children显示文摘 | Bowen A Oudjhane K Odagiri K | | 0，，02： | 1 |
| 13 | Differential expression within the LOX gene family in ripening kiwifruit显示文摘 | ZHANG B CHEN K S BOWEN J ALLAN A ESPLEY R KARUNAIRETNAM S FERGUSON I | 2006 | Journal of Experimental Botany2006，57，14： | 1 |
| 14 | Transient focal ischemia in- duces extensive temporal chants in rat cerebral microRNAome 显示文摘 | DHARAP A BOWEN K PLACE R | 2009 | J Cereb Blood Flow Metab2009，29，4： | 1 |
| 15 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 16 | Putative endogenous mediators of preconditioning-induced ischemic tolerance in rat brain identified by genomic and proteomic analysis显示文摘 | Dhodda V K Sailor K A Bowen K K | 2004 | J Neurochem2004，89，1： | 1 |
| 17 | Transient fo- cal ischemia induces extensive temporal changes in rat cere7 bral microRNAome显示文摘 | DHARAP A BOWEN K PLACE R | 2009 | J Cereb Blood Flow Metab2009，，29： | 1 |
| 18 | Influence of various consolidation techniques on the green microstructure and sintering behavior of alumina powder显示文摘 | ROOSEN A and BOWEN H K | 1988 | J Am Ceram Soc1988，71，： | 1 |
| 19 | Differential expression within the LOX gene family in ripening kiwifruit显示文摘 | ZHANG B CHEN K S BOWEN J ALLAN A ESPLEY R KARUNA1RETNAM S FERGUSON I | 2006 | Journal of Experimental Botany2006，57，： | 1 |
| 20 | Analyses of expressed sequence tags from apple显示文摘 | NEWCOMB R D CROWHURST R N CLEAVE A P RIKKERINK E H A ALLAN A C BEUNING L L BOWEN J H GERA E JAMIESON K R JANSSEN B J LAING W A | 2006 | Plant Physiology2006，141，1： | 1 |
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