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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Quality of different chondroitin sulfate preparations in relation to their therapeutic activity显示文摘 | MEERW ME BOUT J V D | 2009 | J Pharm Pharmacol2009，61，10： | 1 |
| 3 | Immunoglobulins in chronic renal failure of childhood : effects of dialysis melal- ities显示文摘 | Bouts A H Davin J C Krediet R T | 2000 | Kidney int2000，58，： | 1 |
| 4 | Percutaneous cannulated screw fixation of femoral neck fractures:the three point principl显示文摘 | Bout CA Cannegieter DM Juttmann JW | | 0，，： | 1 |
| 5 | Immunodiagnosis of hydatidosis using monospecific immune serum anti-Ag5显示文摘 | Bout D Carlier Y Capron A | 1979 | Biomedicine1979，31，7： | 1 |
| 6 | Lung gene therapy:in vivo adenovirus-mediated gene transfer to rhesus monkey airway epithelium显示文摘 | Bout A Perricaudet M Baskin G | 1994 | Hum Gene ther1994，5，1： | 1 |
| 7 | Prospects for a human Toxoplasma vaccine显示文摘 | Bout DT Mevelec MN Velge-Roussel F | 2002 | Curr Drug Targets Immune Endocr Metabol Disord2002，2，3： | 1 |
| 8 | Purification of a specific antigen from hydatid fluid (author's transl)显示文摘 | Bout D Fruit J Capron A | 1974 | Ann Immunol (Paris)1974，125，5： | 1 |
| 9 | Imaging molecular and nanoscale order in conjugated polymer thin films with near-field scanning optical microscopy显示文摘 | Teetsov J A Vanden Bout D A | 2001 | J Am Chem Soc2001，123，15： | 1 |
| 10 | Nudear factor kappa B, cancer, mad apoptosis 显示文摘 | Bouts V Bentires-Alij M Hellin A | 2000 | Bioehem Pharmaeol2000，65，8： | 1 |
| 11 | Interferon-gamma-activated primary enterocytes inhibit Toxoplasma gondii replication:a role for intracellular iron显示文摘 | DIMIER IH BOUT DT | 1998 | Immunology1998，94，4： | 1 |
| 12 | Podocin lo- the kidney to the slit diaphragm area显示文摘 | Roselli S Gribouvai O Boute N | 2002 | Am J Pathol2002，160，1： | 1 |
| 13 | Development and evaluation of a guideline for nursing care of suicidal patients with schizophrenia显示文摘 | Meerwijk EL Van MB den Bout JV | | 0，，01： | 1 |
| 14 | Prospects for a human Toxoplasma vaccine显示文摘 | Bout DT Mevelec MN Velge-Roussel F | 2002 | Curr Drug Targets Immune Endoer Metabol Disord2002，2，3： | 1 |
| 15 | Oral immunization with Toxoplasma gondii antigens in association with cholera toxin induces enhanced protective and cell-mediated immunity in C57BL/6 mice显示文摘 | Bourguin I Chardes T Bout D | 1993 | Infect Immun1993，61，5： | 1 |
| 16 | Adenosine 5' -triphos- phate and adenosine as endogenous signaling molecules inimmunity and inflammation显示文摘 | Bouts MJ Swennen EL Di Virgilio F | 2006 | Pharmacol Ther2006，112，2： | 1 |
| 17 | Splicing mutations in DMD/BMD detected by RT-CR/PTT: detection of a 19AA insertion in the cysteine rich domain of dystrophyin compatible with BMD显示文摘 | Roest PA Bout M van der Tuijn AC | 1996 | J Med Genet1996，33，11： | 1 |
| 18 | Intranasal immunization with SAG1 protein of Toxoplasma gondii in association with cholera toxin dramatically reduces development of cerebal cyst after oral infection显示文摘 | Debard N Buzoni-Gatel D Bout D | 1996 | Infect Immun1996，64，6： | 1 |
| 19 | Processing, structure and tribological behaviour of TiC-reinforced plasma sprayed coatings 显示文摘 | Economou S Boute M D Cells J P | 1998 | Wear1998，220，1： | 1 |
| 20 | Graph partitioning use annealing neural networks显示文摘 | Van den Bout D E Miller T K | 1990 | IEEE Transactions on Neural Networks1990，1，2： | 1 |
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