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| 1 | Nuclear magnetic resonance based metabolomics and liverdiseases:Recent advances and future clinical applications显示文摘Metabolomics is defined as the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification.It is an'omics'technique that is situated downstream of genomics,transcriptomics and proteomics.Metabolomics is recognized as a promising technique in the field of systems biology for the evaluation of global metabolic changes.During the last decade,metabolomics approaches have become widely used in the study of liver diseases for the detection of early biomarkers and altered metabolic pathways.It is a powerful technique to improve our pathophysiological knowledge of various liver diseases.It can be a useful tool to help clinicians in the diagnostic process especially to distinguish malignant and non-malignant liver disease as well as to determine the etiology or severity of the liver disease.It can also assess therapeutic response or predict drug induced liver injury.Nevertheless,the usefulness of metabolomics is often not understood by clinicians,especially the concept of metabolomics profiling or fingerprinting.In the present work,after a concise description of the different techniques and processes used in metabolomics,we will review the main research on this subject by focusing specifically on in vitro proton nuclear magnetic resonance spectroscopy based metabolomics approaches in human studies.We will first consider the clinical point of view enlighten physicians on this new approach and emphasis its future use in clinical'routine'. | Roland Amathieu Mohamed Nawfal Triba Corentine Goossens Nadia Bouchemal Pierre Nahon Philippe Savarin Laurence Le Moyec | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 2 | Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin显示文摘 | Sajeesh S Bouchemal K Marsaud V | 2010 | Journal of Controlled Release2010，147，3： | 1 |
| 3 | Methods for the Preparation and Manufacture of Polymeric Nanoparticles显示文摘 | Christine Vauthier Kawthar Bouchemal | 2009 | Pharmaceutical Research2009，，5： | 1 |
| 4 | Cyclodextrin complexed insulin encapsulated hydrogel microparticles:an oral delivery system for insulin显示文摘 | Sajeesh S Bouchemal K Marsaud V | 2010 | J Control Release2010，147，3： | 1 |
| 5 | Nano - emulsion formulation using spontaneous emulsification : Solvent, oil and surfactant optimisation 显示文摘 | BOUCHEMAL K BRIANCON S PERRIER E | 2004 | Int J Pharm2004，280，： | 1 |
| 6 | Synthesis and characterization of polyurethane and poly (ether-urethane) nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification 显示文摘 | BOUCHEMAL K BRIANCON S PERRIER E | 2004 | International Journal of Pharmaceutics2004，269，1： | 1 |
| 7 | Synthesis and characterization of polyurethane and poly ( ether urethane) nanocapsules using a new technique of interracial polycondensation combined spontaneous emulsification 显示文摘 | Bouchemal K Briancon S Perrier E | 2004 | International Journal of pharmaceutics2004，269，1： | 1 |
| 8 | Synthesis polyurethane and poly (etherurethane) nanocapsules using a new technique of interracial polycondensation combined spontaneous emulsification 显示文摘 | Bouchemal K Brianconand characterization ofS Perrier E | 2004 | International Journal of Pharmaceutics2004，269，1： | 1 |
| 9 | Methods for the preparation and manufacture of polymeric nanoparticles 显示文摘 | VAUTHIER C BOUCHEMAL K | 2009 | Pharm Res2009，26，5： | 1 |
| 10 | Nano-emulsion for- mulation using spontaneous emulsification: Solvent, oil and surfactant optimization 显示文摘 | Bouchemal K Briancon S Perrier E | 2004 | International Journal of Pharma- ceutics2004，280，： | 1 |
| 11 | Intestinal permeation enhancement of docetaxel encapsulated into methyl-β- eycIodextrin/poly(isobutylcyanoacrylate) nanoparticels coated with thiolated chitosan显示文摘 | Mazzaferro S Bouchemal K Skanji R | 2012 | J Control Release2012，162，3： | 1 |
| 12 | Nano-emulsion formulation using spontaneous emulsification: Solvent, oil and surfactant optimization显示文摘 | Bouchemal K Briancon S Perrier E | 2004 | International Journal of Pharmaceutics2004，280，12： | 1 |
| 13 | Intestinal permeation enhancement of docetaxel encapsulated into methyl-β-cyclodextrin/ poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chi- tosan 显示文摘 | Mazzaferro S Bouchemal K Skanji R | 2012 | J Control Release2012，162，3： | 1 |
| 14 | Synthesis and characterization of polyurethane and poly( ether urethane) nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification 显示文摘 | BOUCHEMAL K BRIANCON S PERRIER E | 2004 | International Journal of Pharmaceutics2004，269，1： | 1 |
| 15 | Cyclodextrin complexed insulin encapsulated hydrogel microparticles:An oral delivery system for insulin显示文摘 | Sajeesh S Bouchemal K Marsaud V | | 0，，03： | 1 |
| 16 | Nano-emulsion for- mulation using spontaneous emulsification: Solvent, oil and surfactant optimisation 显示文摘 | Bouchemal K Briancon S Perrier E | 2004 | International Journal of Pharma- ceutics2004，280，： | 1 |
| 17 | Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimization显示文摘 | Bouchemal K Briancon S Perrier E | 2004 | Int J Pharm2004，280，1： | 1 |
| 18 | Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin显示文摘 | Sajeesh S Bouchemal K Marsaud V | 2010 | J Control Rel2010，147，3： | 1 |
| 19 | Nano-emulsion formulation using spontaneous emulsification:solvent,oil and surfactant optimization显示文摘 | Briancon S Perrier E | 2004 | Int J Pharm2004，280，12： | 1 |
| 20 | Auto-associative amphiphilic polysaccharides as drug delivery systems显示文摘 | Leila N. Hassani Frédéric Hendra Kawthar Bouchemal | 2012 | Drug Discovery Today (-)2012，，11： | 1 |
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