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| 1 | Epigenetic regulation: methylation of histone and non-histone proteins显示文摘Histone methylation is believed to play important roles in epigenetic memory in various biological processes. However, questions like whether the methylation marks themselves are faithfully transmit- ted into daughter cells and through what mechanisms are currently under active investigation. Previ- ously, methylation was considered to be irreversible, but the recent discovery of histone lysine de- methylases revealed a dynamic nature of histone methylation regulation on four of the main sites of methylation on histone H3 and H4 tails (H3K4, H3K9, H3K27 and H3K36). Even so, it is still unclear whether demethylases specific for the remaining two sites, H3K79 and H4K20, exist. Furthermore, be- sides histone proteins, the lysine methylation and demethylation also occur on non-histone proteins, which are probably subjected to similar regulation as histones. This review discusses recent pro- gresses in protein lysine methylation regulation focusing on the above topics, while referring readers to a number of recent reviews for the biochemistry and biology of these enzymes. | LAN Fei1 & SHI Yang 2 1 Department of Biology, Constellation Pharmaceuticals, 148 Sidney Street, Cambridge, MA 02139, USA 2 Department of Pathology, Harvard Medical School, 77 Ave Louise Pasteur, Boston MA, 02115, USA | 2009 | Science China(Life Sciences)2009，52，4： | 27 |
| 2 | The definition of effective emissivity of land surface at the scale of remote sensing pixels显示文摘Remote sensing (RS) of land surface temperature (LST) is a very challenging problem at the present development stage of RS science. Tremendous efforts have been devoted to atmosphere correction and temperature emissivity separation (TES) of new LST product algorithms. However, the mechanism of directionality of thermal emission from land surface remains unknown, and even worse, there are confusions on the definition of the effective emissivity of land surface at the scale of RS pixels. The mechanism of directionality of thermal emission | LI Xiaowen and WANG Jindi Research Center for Remote Sensing and GIS, Beijing Normal Unirersity, Keying 100875, China Center for Remote Sensing, Boston Univ. , MA02215, USA | 1999 | Chinese Science Bulletin1999，44，23： | 14 |
| 3 | Rapid mitogen-activated protein kinase activation by transforming growth factor α in wounded rat intestinal epithelial cells显示文摘RapidmitogenactivatedproteinkinaseactivationbytransforminggrowthfactorαinwoundedratintestinalepithelialcelsMichaelGkee,Michi... | Michael Gke, Michiyuki Kanai, Kathryn Lynch Devaney, and Daniel K. Podolsky Gastrointestinal Unit, Department of Medicine, and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massa | 1998 | World Journal of Gastroenterology1998，4，3： | 14 |
| 4 | A NEW QUANTITATIVE WAY FOR DETERMINING LEAF AREA INDEXAND NET PRIMARY PRODUCTIVITY IN REGIONAL SCALE显示文摘An inversion of bidirectional reflection distribution fiJnedon (BRDF) wastested using NK Model and NOAA AVHRR datu. The test involVed sensitiveanalysis, optimum inversion selecting, ground simulated expenment, calibrahngmeasuremed with satellite and computer image processmg. Results of comparisonwith NDVI indicatal that inversion of BRDF will have brigh developing prospect inthe next decade. | Zhang Renhua(Institute of Geography, CAS, Bejing 100101, P.R. China)Andres Kuusk(Estorua Observatory, Tatu, Estorua)Chen Gang(Ground Station of Satellite Remote Sensing, CAS, Behing 100086, P.R. China)Alan Strahler Li Xiaonen(Remote Sensing Cater, Boston | 1996 | Journal of Geographical Sciences1996，6，4： | 7 |
| 5 | Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc^(min) mice显示文摘AIM:To investigate whether Recql5,a DNA helicase that plays an important role in the maintenance of genome integrity,is a tumor suppressor in the gastrointestinal tract in mice.METHODS:We generated cohorts of both Recql5-proficient and Recql5-deficient Apcmin/+mice and compared the tumor susceptibility in their gastrointestinal tracts.RESULTS:Recql5 deficiency in Apcmin/+mice resulted in a significant increase in the tumor incidence in both the colon(P=0.0162)and the small intestine(P<0.01).These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice.Importantly,since mouse Recql5 and human RECQL5 are highly conserved,these findings also suggest that RECQL5 may be a tu-mor suppressor for human colon cancer.CONCLUSION:Recql5 has a tumor suppression role in the mouse gastrointestinal tract. | Yiduo Hu,Xincheng Lu,Guangbin Luo,Department of Genetics,Case Comprehensive Cancer Center and University Hospitals of Cleveland,Case Western Reserve University,Cleveland,OH 44106,United States Yiduo Hu,Department of Cancer Biology,Dana-Farber Cancer Institute,Boston,MA 02115,United States | 2010 | World Journal of Gastroenterology2010，16，12： | 6 |
| 6 | Intrinsic control of axon regeneration显示文摘Spinal cord injury disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. The most important reason for such permanent functional deficits is the failure of injured axons to regenerate after injury. In principle, the functional recovery could be achieved by two forms of axonal regrowth: the regeneration of lesioned axons which will reconnect with their original targets and the sprouting of spared axons that form new circuits and compensate for the lost function. Our recent studies reveal the activity of the mammalian target of rapamycin (mTOR) pathway, a major regulator of new protein synthesis, as a critical determinant of axon regrowth in the adult retinal ganglion neurons[1]. In this review, I summarize current understanding of the cellular and molecular mechanisms that control the intrinsic regenerative ability of mature neurons. | Zhigang He F.M. Kirby Neurobiology Center, Children’s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. | 2010 | The Journal of Biomedical Research2010，24，1： | 6 |
| 7 | Second-order consensus in networks of dynamic agents with communication time-delays显示文摘This paper proposes second-order consensus protocols with time-delays and gives the measure of the robustness of the protocols to the time-delay existing in the network of agents with second-order dynamics. By employing a frequency domain method, it is proven that the information states and their time derivatives of all the agents in the network achieve consensus asymptotically, respectively, for appropriate communication timedelay if the topology of weighted network is connected. Particularly, a tight upper bound on the communication time-delay that can be tolerated in the dynamic network is found. The consensus protocols are distributed in the sense that each agent only needs information from its neighboring agents, which reduces the complexity of connections between neighboring agents significantly. Numerical simulation results are provided to demonstrate the effectiveness and the sharpness of the theoretical results for second-order consensus in networks in the presence of communication time-delays. | Bo Yang1,2, Huajing Fang3, and Hua Wang4 1. School of Navigation, Wuhan University of Technology, Wuhan 430063, P. R. China 2. Wuhan Second Ship Design and Research Institute, Wuhan 430064, P. R. China 3. Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China 4. Department of Aerospace and Mechanical Engineering, Boston University, Boston MA02215, USA | 2010 | Journal of Systems Engineering and Electronics2010，21，1： | 5 |
| 8 | Inducible resistance to Fas-mediated apoptosis in B cells显示文摘Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expres. sion and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surfaceim. munoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglob- 'lin signaling for inducible Fas-resistance bypasses Bib, requires NF-GB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; maim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity. | ROTHSTEIN THOMAS L Departments of Medicine and Microbiology, and the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA, USA | 2000 | Cell Research2000，10，4： | 4 |
| 9 | Nonlinear dynamics of self-oscillating polymer gels显示文摘Self-oscillating polymer gels driven by Belousov-Zhabotinsky (BZ) chemical reaction are a new class of functional gels that have a wide range of potential applications (e.g., autonomously functioning membranes, actuate artificial muscles). However, the precise control of these gels has been an issue due to limited investigations of the influences of key system parameters on the characteristics of BZ gels. To address this deficiency, we studied the self-oscillating behavior of BZ gels using the nonline-ar dynamics theory and an Oregonator-like model, with focus placed upon the influences of various system parameters. The analysis of the oscillation phase indicated that the dynamic response of BZ gels represents the classical limit cycle oscillation. We then investigated the characteristics of the limit cycle oscillation and quantified the influences of key parameters (i.e., ini-tial reactant concentration, oxidation and reduction rate of catalyst, and response coefficient) on the self-oscillating behavior of BZ gels. The results demonstrated that sustained limit cycle oscillation of BZ gels can be achieved only when these key pa-rameters meet certain requirements, and that the pattern, period and amplitude of the oscillation are significantly influenced by these parameters. The results obtained in this study could enable the controlled self-oscillation of BZ gels system. This has several potential applications such as controlled drug delivery, miniature peristaltic pumps and microactuators. | WANG PengFei1, ZHOU JinXiong1, LI MeiE2, XU Feng1,3 & LU TianJian1 1 Biomedical Engineering and Biomechanics Center, SV Laboratory, Xi’an Jiaotong University, Xi’an 710049, China 2 School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an 710049, China 3 HST Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, 510660, USA | 2010 | Science China(Technological Sciences)2010，53，7： | 3 |
| 10 | Age- and gender-dependent obesity in individuals with 16pl1.2 deletion显示文摘Recurrent genomic imbalances at 16p 11.2 are genetic risk factors of variable penetrance for developmental delay and autism.Recently, 16pl 1.2(chr16:29.5 Mb—30.1 Mb) deletion has also been detected in individuals with early-onset severe obesity.The penetrance of 16p11.2 deletion as a genetic risk factor for obesity is unknown.We evaluated the growth and body mass characteristics of 28 individuals with 16p11.2 (chr16:29.5 Mb—30.1 Mb) deletion originally ascertained for their developmental disorders by reviewing their medical records.We found that nine individuals could be classified as obese and six as overweight.These individuals generally had early feeding and growth difficulties,and started to gain excessive weight around 5—6 years of age.Thirteen out of the 18 deletion carriers aged 5 years and older(72%) were overweight or obese,whereas only two of 10 deletion carriers(20%) younger than five were overweight or obese.Males exhibited more severe obesity than females.Thus,the obesity phenotype of 16p11.2 deletion carriers is of juvenile onset,exhibited an age- and gender-dependent penetrance. 16p11.2 deletion appears to predispose individuals to juvenile onset obesity and in this case are similar to the well-described Prader-Willi syndrome(PWS).Early detection of this deletion will provide opportunity to prevent obesity. | David T.Miller James F.Gusella Orah S.Platt on behalf of the Children's Hospital Boston Genotype Phenotype Study Group | 2011 | Journal of Genetics and Genomics2011，38，9： | 2 |
| 11 | Purification, properties, and immunohistochemical localization of human brain 14-3-3 protein显示文摘 | Boston P F Jackson P Kynoch P A | 1982 | J Neurochem1982，38，5： | 1 |
| 12 | Disc space infection in children显示文摘 | Boston HC Bianco AJ Jr Rhodes KH | 1975 | Orthop Clin North Am1975，6，10： | 1 |
| 13 | Hardness of enamel exposed to Coca-Cola and artificial saliva显示文摘 | Devlin H Bassiouny MA Boston D | 2006 | J Oral Reha- bil2006，33，1： | 1 |
| 14 | Molecular chaperones and protein folding in plants显示文摘 | Boston RS Viitanen PV Vierling E | 1996 | Plant Mol Biol1996，32，： | 1 |
| 15 | MINMOD millenn-ium:a computer program to calcuate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test显示文摘 | Stefanovski D Moate PJ | 2003 | Diabetes Technol Ther2003，5，6： | 1 |
| 16 | Endoplasmic Retieulum Quality Control and theUnfolded Protein Response: Insights from Plants 显示文摘 | VITALE A BOSTON R S | 2008 | Blackwell Munks- gaard2008，9，： | 1 |
| 17 | Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis 显示文摘 | Selhub J JacquesPF Boston AG | 1995 | N Engl J Med1995，332，5： | 1 |
| 18 | Purification,properties,and immunohistochemical localisation of human brain 14-3-3 protein显示文摘 | Boston P F Jackson P Kynoch P A | 1982 | J Neurochem1982，38，： | 1 |
| 19 | Comparison of mania and depress sion after brain injury: causal factors 显示文摘 | ROBINSON R G BOSTON J D STARKEIN S E | 1988 | Am J Psychiatry1988，145，2： | 1 |
| 20 | MINMOD millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test显示文摘 | Boston RC Stefanovski D Moate PJ | 2003 | Diabetes Technol Ther2003，5，6： | 1 |
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