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| 1 | Model acupuncture point:Bone marrow-derived stromal stem cells are moved by a weak electromagnetic field显示文摘AIM To show the existence of a structural formative role of magnetic fields(MFs) with respect to biological objects by using our proposed model of an acupoint.METHODS We introduced a magnetised 10-100 μT metal rod(needle) into culture dishes with a negatively charged working surface and observed during 24 h how cells were arranged by MFs and by electrical fields(EFs) when attached. Rat and human bone marrow-derived stromal stem cells(r BMSCs and h BMSCs), human nonadherent mononuclear blood cells, NCTCs and A172 cells, and Escherichia coli(E. coli) were evaluated. The dish containing BMSCs was defined as the model of an acupoint. r BMSCs proliferative activity affected by the needle was investigated. For investigating electromagnetic field structures, we used the gas discharge visualisation(GDV) method.RESULTS During 24 h of incubation in 50-mm culture dishes, BMSCs or the nonadherent cells accumulated into a central heap in each dish. BMSCs formed a torus(central ring) with an inner diameter of approximately10 mm only upon the introduction of the needle in the centre of the dish. The cells did not show these effects in 35- or 90-mm culture dishes or hydrophobic dishes or rectangular cuvettes. NCTCs and A172 cells showed unstable the effects and only up to two weeks after thawing. Moreover, we observed that the appearance of these effects depended on the season. In winter, BMSCs showed no the effects. GDV experiments revealed that the resonant annular illumination gradually formed from 10 to 18-20 s in polar solutions with and without cell suspension of BMSCs, NCTCs and E. coli when using circular 50-mm dishes, stimulation at 115 V and switching of the electrode poles at 1 kH z. All these data demonstrate the resonant nature of the central ring. Significant influence of MFs on the rB MSC proliferation rate was not observed.CONCLUSION BMSCs can be moved by MFs when in the presence of a constant EF and MF, when the cells are in the responsive functional state, and when there is a resonant relationship between them. | Artem N Emelyanov Marina V Borisova Vera V Kiryanova | 2016 | World Journal of Stem Cells2016，8，10： | 2 |
| 2 | Effects of modification of the polar ionosphere with high-power short-wave extraordinary-mode HF waves produced by the spear heating facility显示文摘 | T. Borisova N. Blagoveshchenskaya A. S.Kalishin K. Oksavik L. Baddelley T. K.Yeoman | 2012 | Radiophysics and Quantum Electronics2012，，1： | 2 |
| 3 | Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family显示文摘AIM: To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer (HNPCC) family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers. METHODS: The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the pro-band. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced. RESULTS: The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining. CONCLUSION: The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor. The primary tumor localizations were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria. | Tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky | 2006 | World Journal of Gastroenterology2006，12，48： | 2 |
| 4 | Influence of serum levels of thyroid-stimulating hormone and anti-thyroid peroxidase antibodies,age and gender on depression as measured by the Zung Self-Rating Depression Scale显示文摘 | Shinkov AD Borisova AM Kovacheva RD | 2014 | Folia Med(Plovdiv)2014，56，1： | 1 |
| 5 | Alcohol consumption, smoking and risk of gastric cancer:case-control study from Moscow, Russia显示文摘 | Zaridze D Borisova E Maximovitch D | 2000 | Cancer Causes Control2000，11，4： | 1 |
| 6 | Behavior of a short preS1 epitope on the surface of hepatitis B core particles显示文摘 | Borisova G Borschukova O Skrastina D | 1999 | Biol Chem1999，380，3： | 1 |
| 7 | Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa显示文摘 | Pavlina Dolashka Vesela Moshtanska Valika Borisova Aleksander Dolashki Stefan Stevanovic Tzvetan Dimanov Wolfgang Voelter | 2011 | Peptides2011，，7： | 1 |
| 8 | Behaviour of a short preS1 epitope on the surface of hepatitis B core particles显示文摘 | Borisova G Borschukova O Sknastina D | 1999 | Biol Chem1999，380，3： | 1 |
| 9 | Isolation and characterization of VceC gain-of-function mutants that can function with the AcrAB multiple-drug-resistant efflux pump of Escherichia coli显示文摘 | BORISOVA T FFAI ICK JA | 2006 | Bacteriol2006，188，11： | 1 |
| 10 | The A-factor,responsible for streptomycin biosynthesis by mutant strain of Actinomyces streptomycini显示文摘 | Khokhlov A S Tovarova Ⅱ Borisova L N | 1967 | Dokl AkAD Nauk SSRR1967，177，1： | 1 |
| 11 | Palaeohydrology of the Seim River basin, mid-Russian upland, based on palaeochannel morphology and palynological data显示文摘 | BORISOVA O K SIDORCHUK A PANIN A | 2006 | Catena2006，66，12： | 1 |
| 12 | A hantavirus nucleocapsid protein segment exposed on hepatitis B virus core particles is highly immunogenic in mice when applied without adjuvants or in the presence of pre-existiing anti-core antibodies显示文摘 | Geldmacher A Skrastina D Borisova G | | 0，，30： | 1 |
| 13 | Morphology of river channels and surface runoff in the Volga River basin ( East European Plain) during the Late Glacial period显示文摘 | SIDORCHUK A PANIN A BORISOVA O K | 2009 | Geomorphology2009，113，： | 1 |
| 14 | Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachlo- ride-induced acute liver damage in rats显示文摘 | Valcheva-Kuzmanova S Borisova P Galunska 13 | 2004 | Experimental and Toxicologic Pathology2004，56，： | 1 |
| 15 | Aspirin protects against gastric cancer :results of a case-control study from Moscow, Russia显示文摘 | Zaridze D Borisova E Maximovitch D | 1999 | Int J Cancer1999，82，4： | 1 |
| 16 | Synthesis of 5-trimethylsilylethynyl-1,3,4-oxadiazoles显示文摘 | DEMINA M SARAPULOVA G BORISOVA A | 2003 | Russ J Org Chem2003，39，10： | 1 |
| 17 | 显示文摘 | Bokhonov B Borisova Yu Korchagin M | 2004 | Carbon2004，42，10： | 1 |
| 18 | The A- factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini 显示文摘 | Khokhlov AS Tovarova Ⅱ Borisova LN | 1967 | Dokl AkAD Nauk SSRR1967，177，： | 1 |
| 19 | Spatial structure and insertion capacity of immundomminant region of heaptits B core antigen显示文摘 | Borisova G Wanst OB Meaule G | 1996 | Intervirology1996，39，： | 1 |
| 20 | Germination capacity and patterns of seed germination in some steppe and meadow plants of Mongolia显示文摘 | Borisova I V | 1994 | Bot Zhur1994，79，10： | 1 |
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