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| 1 | Method development for the determination of cadmium in fertilizer samples using high-resolution continuum source graphite furnace atomic absorption spectrometry and slurry sampling显示文摘 | Aline R. Borges Emilene M. Becker Céline Lequeux Maria Goreti R. Vale Sergio L.C. Ferreira Bernhard Welz | 2011 | Spectrochimica Acta Part B: Atomic Spectroscopy2011，，7： | 3 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment显示文摘 | CURSIEFEN C CHEN L BORGES L P | 2004 | J Clin Invest2004，113，7： | 1 |
| 4 | Study of the synthesis of poly(4,4'- diphenylether-1,3,4-oxadiazole) in solutions of poly (phosphoric acid)显示文摘 | Comes D Borges C P Pinto J C | 2001 | Polymer2001，42，3： | 1 |
| 5 | Recovery of impaired K ^+ channels in mesenteric arteries from spontaneously hypertensive rats by prolonged treatment with eholecalciferol 显示文摘 | Borges A C R Feres T Vianna L M | 1999 | Br J Pharmacol1999，127，： | 1 |
| 6 | VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment 显示文摘 | Cursiefen C Chen L Borges LP | 2004 | J Clin Invest2004，113，7： | 1 |
| 7 | Spatial and temporal variation of phytoplankton in two subtropical Brazilian reservoirs 显示文摘 | BORGES P A F TRAIN S RODRIGUES L C | 2008 | Hydrobiologia2008，607，： | 1 |
| 8 | Total least squares fitting of Bezier and B-spline curves to ordered data 显示文摘 | Borges C F Pastva T | 2002 | Computer Aided Geometric Design2002，19，4： | 1 |
| 9 | Life satisfaetion among informalearegivers in comparison with non-caregivers 显示文摘 | Borg C Hallberg IR | 2006 | Scand J Caring Sci2006，20，4： | 1 |
| 10 | An efficient, thermally stable cerium-based silicate phosphor for solid state white lighting显示文摘 | Brgoch J Borg C K H Denanlt K A | 2013 | Inorg Chem2013，52，14： | 1 |
| 11 | Multistage expansion planning for active distribution networks under demand and distributed generation uncertainties显示文摘 | BORGES C L T MARTINS V F | 2012 | International Journal of Electrical Power Energy Systems2012，36，1： | 1 |
| 12 | Uptake and transport of manganese in primary and secondary olfactory neurones in pike显示文摘 | Tjalve H Mejàre C Borg Neczak K | 1995 | Pharmacol Toxicol1995，77，1： | 1 |
| 13 | Tonin in rat heart with experimental hypertrophy显示文摘 | BORGES J C SILVA J A Jr GOMES M A | 2003 | Am J Physiol Heart Circ Physiol2003，284，6： | 1 |
| 14 | Identifying improvements in water management of bus-washing stations in Brazil显示文摘 | Almeida C M V B Borges J D Bonilla S H | 2010 | Resources Conservation and Recycling2010，54，11： | 1 |
| 15 | Kinetic Resolution of(R,S)-1,2-Isopropylidene Glycerol(Solketal)Ester Derivatives by Lipases显示文摘 | Machado A C O Da Silva A A T Borges C P | 2011 | J Mol Catal B:Enzym2011，69，1： | 1 |
| 16 | Active distribution network integrated planning incorporating distributed generation and load response uncertainties显示文摘 | MARTINS V F BORGES C L T | 2011 | IEEE Trans on Power Systems2011，26，4： | 1 |
| 17 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 18 | Perihoeral administration of a long-chain fatty alcohol promotes septaleholinergic neurous survival after tim bria-fomix transaction显示文摘 | Borg J Kesslak P J Cotman C W | 1990 | Brain Res1990，，： | 1 |
| 19 | Accumulation of waterbome mercury(Ⅱ) in specific areas of fish brain显示文摘 | Rouleau C Borg Neczak K Gottofrey J | 1999 | ES & T1999，333，： | 1 |
| 20 | Enteric bacterial catalysts for fuel ethanol production 显示文摘 | Ingram L O Aldrich H C Borges A C C | 1999 | Biotechnology Progress1999，15，5： | 1 |
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