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| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | 马王堆帛书《式法》释文摘要显示文摘1973年湖南长沙马王堆三号汉墓出土的帛书,有一种在过去报道中通称“篆书阴阳五行”,其内容实际是选择吉凶时曰的数术,与湖北云梦睡虎地十一号秦墓所出竹简《曰书》相类,而更多与“式”的运作有关,今暂题为《式法》。目前《式法》的整理工作尚未全部完成,现选刊其中七部分的释文,供学术界研究。 | The Study Group for the Silk Books from Mawangdui | 2000 | 文物2000，，7： | 20 |
| 3 | Inflammatory pseudotumor of the liver: 13 cases of MRI findings显示文摘INTRODUCTIONInflammatory pseudotumor of the liver ,a rare benign lesion ,is often confused with the malignant tumors .Until 1998,less than 80 cases had been reported in the world [1,2].The accuracy of the pre-surgical diagnosis was low p[3,4] ,and very few materials on the diagnosis using dynamic MRI were reported [5-7] .We collected thirteen cases of inflammatory pseudotumor of the liver were collected and roved by pathology with MRI studies .Our purpose is to describe and analyze the MRI findings of this lesion and find out the valuable signs suggesting the diagnosis so as to avoid unnecessary operations. | Fu Hua Yan Kang Rong Zhou Ya Ping Jiang Wei Bin Shi Department of Radiology,Zhongshan Hospital,Medical Center of Fudan University (Former Shanghai Medical University),180 Fenglin Road,Shanghai 200032,ChinaDr.Fu Hua Yan graduated from Shanghai Medical University as a postgraduate in 1996,now an associated professor,a radiologist in chief specialized in the diagnosis of CT and MRI in hepatic diseases,having 22 papers published.She is the associated editor of the books Spiral CT and Body MRI. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 4 | New Development of China-Russia-India Triangle显示文摘Since 2001, positive improvement has occurred in the trianglerelationship between China, Russia and India. The foreignministers of the three nations met in Russia recently, symbolizingthe launching of substantive triangular cooperation. | Ma Jiali is Research Professor at CICIR. He specializes in South Asian security, especially in India’s foreign policy. He is the author of three books, such as Pay Close Attention to India: A Rising Power which is very influential. He was one of the delegates for Track Two Dialogue between China and India for all of four rounds and a delegate for Track Two Dialogue between China, Russia and India. He is also a member of Eminent Persons Group Forum between China and India. | 2005 | Contemporary International Relations2005，15，7： | 4 |
| 5 | “Color Revolutions” and Beyond显示文摘“Color revolutions” (or “orange revolutions”) broke out in some of the Commonwealth of Independent States in the past couple of years, reminiscent of the drama of disintegration of the former Soviet bloc at the turn of the 1990s. Why those upheavals came hot on the heels of the Soviet collapses merely a dozen or so years ago? Are we expecting more domino effects down the road? What geographical repercussions will they spark? A panel discussion was held on the topic and their views published in the journal. | Dr. Ji Zhiye is Research Professor and Assistant President of China Institutes of Contemporary International Relations (CICIR), and Director of the Institute of Russian Studies concurrently. He is editor and coauthor of many books including Russian Think-Tanks on Foreign Affairs and The Shanghai Cooperation Organization——New Security and New Mechanism. Dr. Xu Tao is Research Professor and Deputy Director of the Institute of Russan Studies, CICIR. Jiang Li is Associate Research Professor of the Institute of Russian Studies, CICIR. Da Wei is Assistant Director of the Institute of American Studies, CICIR. Dr. Chen Xiangyang is Deputy Director of the Center for Strategic Studies, CICIR. Ding Xiaoxing is Assistant Research Professor of the Institute of Russian Studies, CICIR. | 2005 | Contemporary International Relations2005，15，6： | 3 |
| 6 | Assessment of a new self-rating Scale for post-traumatic stress disorder显示文摘 | Davidson JRT Book SW Colaet JT | 1997 | Psy Med1997，27，： | 1 |
| 7 | Flux-corrected transport II:Generalization of the method显示文摘 | Book D L Boris J P Hain K | 1975 | J Comput Phys1975，18，： | 1 |
| 8 | Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping显示文摘 | Book C Walter J Paulsen M | 2008 | Nucleic Acids Res2008，36，10： | 1 |
| 9 | A proposed stan- dard system of nomenclature of human mitotic chro- mosomes (Denver, Colorado) 显示文摘 | Lejeune J Levan A Book JA | 1960 | The Lancet1960，275，7133： | 1 |
| 10 | Myoglobin content in human skeletal muscle and myocardium:Relation to fiber size and oxidative capacity显示文摘 | Sylven C Jansson E Book K | 1984 | Cardiovasc Res1984，18，： | 1 |
| 11 | GHz microwave absorption of a fine α-Fe structure produced by the disproportionation of Sm2Fe17 in hydrogen 显示文摘 | SUGIMOTO S MAEDA T BOOK D | 2002 | J Alloys Comp2002，，： | 1 |
| 12 | Evaluation of posttransplant RhD sensitization in Rh D-negative renal recipients显示文摘 | Book K Agarwal A Filo S | | 0，，08： | 1 |
| 13 | The Acquisition and Use of an Internal Representation of the Spatial Layout of the Environment During Location显示文摘 | GARLING T BOOK A LINGDBERG E | 1979 | Man-Environment System1979，9，： | 1 |
| 14 | On the approximability of two capacitated vehicle routing problems 显示文摘 | Book A SanitL | 2013 | Electronic Notes in Discrete Mathematics2013，1，41： | 1 |
| 15 | Convolution Analysis of Milling Force Pulsation显示文摘 | Wang J J Liang S Y Book W J | 1994 | ASME Journal of Engineering Industries1994，116，： | 1 |
| 16 | Nitric oxide as a bifunctional regulator of apoptosis 显示文摘 | Kim YM BoOk CA Billiar TR | 1999 | Circ Res1999，84，3： | 1 |
| 17 | SHASTA, a fluid transport algorithm that works显示文摘 | BORIS J P BOOK D L Flux-corrected transport: I | 1973 | Journal of Computational Physics1973，11，1： | 1 |
| 18 | Flux-corrected transport algorithm that works显示文摘 | Boris J P Book D L | 1973 | Compute Phys1973，11，： | 1 |
| 19 | Screening of copy number polymorphisms in human β-defensin genes using modified real-time quantitative PCR显示文摘 | CHEN Q X BOOK M FANG X M | 2006 | J Immunol Methods2006，308，： | 1 |
| 20 | Enhancement of the anisotropy of NdFeB powders varying the HDDR conditions 显示文摘 | Nakamura H Kato K Book D | 1999 | J Magn Soc Japan1999，23，： | 1 |
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