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| 1 | Esophageal motility abnormalities in gastroesophageal reflux disease显示文摘Esophageal motility abnormalities are among the main factors implicated in the pathogenesis of gastroesophageal reflux disease. The recent introduction in clinical and research practice of novel esophageal testing has markedly improved our understanding of the mechanisms contributing to the development of gastroesophageal reflux disease, allowing a better management of patients with this disorder. In this context, the present article intends to provide an overview of the current literature about esophageal motility dysfunctions in patients with gastroesophageal reflux disease. Esophageal manometry, by recording intraluminal pressure, represents the gold standard to diagnose esophagealmotility abnormalities. In particular, using novel techniques, such as high resolution manometry with or without concurrent intraluminal impedance monitoring, transient lower esophageal sphincter (LES) relaxations, hypotensive LES, ineffective esophageal peristalsis and bolus transit abnormalities have been better defined and strongly implicated in gastroesophageal reflux disease development. Overall, recent findings suggest that esophageal motility abnormalities are increasingly prevalent with increasing severity of reflux disease, from nonerosive reflux disease to erosive reflux disease and Barrett's esophagus. Characterizing esophageal dysmotility among different subgroups of patients with reflux disease may represent a fundamental approach to properly diagnose these patients and, thus, to set up the best therapeutic management. Currently, surgery represents the only reliable way to restore the esophagogastric junction integrity and to reduce transient LES relaxations that are considered to be the predominant mechanism by which gastric contents can enter the esophagus. On that ground, more in depth future studies assessing the pathogenetic role of dysmotility in patients with reflux disease are warranted. | Irene Martinucci Nicola de Bortoli Maria Giacchino Giorgia Bodini Elisa Marabotto Santino Marchi Vincenzo Savarino Edoardo Savarino | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，2： | 24 |
| 2 | Esophageal testing: What we have so far显示文摘Gastroesophageal reflux disease(GERD) is a common disorder of the gastrointestinal tract. In the last few decades, new technologies have evolved and have been applied to the functional study of the esophagus, allowing for the improvement of our knowledge of the pathophysiology of GERD. High-resolution manometry(HRM) permits greater understanding of the function of the esophagogastric junction and the risks associated with hiatal hernia. Moreover, HRM has been found to be more reproducible and sensitive than conventional water-perfused manometry to detect the presence of transient lower esophageal sphincter relaxation. Esophageal 24-h p H-metry with or without combined impedance is usually performed in patients with negative endoscopy and reflux symptoms who have a poor response to anti-reflux medical therapy to assess esophageal acid exposure and symptom-reflux correlations. In particular, esophageal 24-h impedance and p H monitoring can detect acid and non-acid reflux events. Endo FLIP is a recent technique poorly applied in clinical practice, although it provides a large amount of information about the esophagogastric junction. In the coming years, laryngopharyngeal symptoms could be evaluated with up and coming non-invasive or minimally invasive techniques, such as pepsin detection in saliva or pharyngeal p H-metry. Future studies are required of these techniques to evaluate their diagnostic accuracy and usefulness, although the available data are promising. | Nicola de Bortoli Irene Martinucci Lorenzo Bertani Salvatore Russo Riccardo Franchi Manuele Furnari Salvatore Tolone Giorgia Bodini Valeria Bolognesi Massimo Bellini Vincenzo Savarino Santino Marchi Edoardo Vincenzo Savarino | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 8 |
| 3 | Neuroendocrine carcinomas arising in ulcerative colitis:Coincidences or possible correlations?显示文摘Patients with in· ammatory bowel disease (IBD) are at increased risk of colorectal malignancies. Adenocarcinoma is the commonest type of colorectal neoplasm associated with ulcerative colitis (UC) and Crohn's disease, but other types of epithelial and non-epithelial tumors have also been described in inflamed bowel. With regards to non-epithelial malignancies, lymphomas and sarcomas represent the largest group of tumors reported in association with IBD, especially in immunosuppressed patients. Carcinoids and in particular neuroendocrine neoplasms other than carcinoids (NENs) are rare tumors and are infrequently described in the setting of IBD. Thus, this association requires further investigation. We report two cases of neoplasms arising in mild left-sided UC with immuno-histochemical staining for neuroendocrine markers: a large cell and a small cell neuroendocrine carcinoma of the rectum. The two patients were different in age (35 years vs 77 years) and disease duration (11 years vs 27 years), and both had never received immuno-suppressant drugs. Although the patients underwent regular endoscopic and histological follow-up, the two neoplasms were locally advanced at diagnosis. One of the two patients developed multiple liver metastases and died 15 mo after diagnosis. These findings confirm the aggressiveness and the poor prognosis of NENs compared to colorectal adenocarcinoma. While carcinoids seem to be coincidentally associated with IBD, NENs may also arise in this setting. In fact, long-stand-ing in· ammation could be directly responsible for thedevelopment of pancellular dysplasia involving epithelial, goblet, Paneth and neuroendocrine cells. It has yet to be established which IBD patients have a higher risk of developing NENs. | Roberto Grassia Paolo Bodini Paolo Dizioli Teresa Staiano Elena Iiritano Guglielmo Bianchi Federico Buffoli | 2009 | World Journal of Gastroenterology2009，15，33： | 4 |
| 4 | Evaluation of an invitromast cell degranulation test in the context of food allergy towheat 显示文摘 | Bodinier M Brossar D TriballeauS | 2008 | In tArch Allery Immunol2008，146，4： | 1 |
| 5 | Evaluating health-related quality of life, work ability,and disability in pulmonary arterial hypertension: an unmet need显示文摘 | Rubenfire M Lippo G Bodini BD | 2009 | Chest2009，136，2： | 1 |
| 6 | Exhaled breath condensate eicosanoids and sputum eosinophils in asthmatic children: a pilot study显示文摘 | Bodini A Peroni D Vicentini L | 2004 | Pediatr Allergy Immunol2004，15，1： | 1 |
| 7 | An effect of the PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke显示文摘 | Boncoraglio GB Bodini A Brambilla C | 2006 | Cerebrovasc Dis2006，22，23： | 1 |
| 8 | Detecting stress at the whole-ecosystem level: The case of a mountain lake (Lake Santo, Italy) 显示文摘 | Bondavalli C Bodini A Rossetti G | 2006 | Ecosystems2006，9，5： | 1 |
| 9 | Exhaled nitric oxide and sputum eosinophil markers of inflammation in asthmatic children显示文摘 | Piacentini GL Bodini A Costella S | 1999 | Eur Respir J1999，13，： | 1 |
| 10 | Pulmonary arterial hypertension:The key role of echocardiography显示文摘 | Bossone E Bodini BD Mazza A | 2005 | Chest2005，127，： | 1 |
| 11 | Exhaled nitric oxide, serum ECP and airway responsiveness in mild asthmatic children 显示文摘 | Piaeentini GL Bodini A Costella S | 2000 | Eur Respir J2000，15，： | 1 |
| 12 | Azithromycin reduces bronchial hyperresp-onsiveness andneutrophilic airway inflammation in asthmatic children : apreliminary report 显示文摘 | PIACENTINI G L PERONI D G BODINI A | 2007 | Allergy Asthma Proc2007，28，2： | 1 |
| 13 | Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC class Ⅰand peptide with reduced CD8 binding 显示文摘 | Bodinier M Peyrat M A Tournay C | 2000 | Nat Med2000，6，6： | 1 |
| 14 | Acute promyelocytic leukemias share cooperative mutations with other myeloidleukemia subgroups显示文摘 | Riva L Ronchini C Bodini M | | 0，，09： | 1 |
| 15 | Childhood asthmacontrol test and airway inflammation evaluation in asthmaticchildren显示文摘 | Piacentini GL Peroni DG Bodini A | 2009 | Allergy2009，64，12： | 1 |
| 16 | Cu-Zn isotopic variations in the Earth's mantle显示文摘 | Othman D B Luck J M Bodinier J L | 2006 | Geochimica et Cosmo- chimica Acta2006，，： | 1 |
| 17 | Azithromycin reduces bronchial hyperresponsiveness and neutrophilic airway inflammation in asthmatic children:a preliminary report显示文摘 | Piacentini G L Peroni D G Bodini A | 2007 | Allergy Asthma Proc2007，28，： | 1 |
| 18 | Azithromycin reducesbronchial hyper-responsiveness and neutrophilic airwayinflammation in asthmatic children:A preliminary report显示文摘 | Piacentini GL Peroni DG Bodini A | 2007 | Allergy Asthma Proc2007，28，2： | 1 |
| 19 | Azithromycin reduces bronchial hyperresponsiveness and neutrophilic airway inflammation in asthmatic children:a preliminary report显示文摘 | Piacentini GL Peroni DG Bodini A | 2007 | Allergy Asthma Proc2007，28，2： | 1 |
| 20 | High-pressure chemistry of hydrogen in metals:in situ study of iron hydride显示文摘 | Bodinier J L Vasseur G Verneres J | 1990 | Nature1990，353，： | 1 |
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