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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases显示文摘AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein expression by immunohistochemistry (IHC) in 294 paraffin-embedded liver specimens comprising all stages of hepatocellular carcinogenesis. In addition, in cell culture experiments HBV-positive (HepG2.2.15 and HB611) and HBV-negative (HepG2) hepatoma cell lines were tested for the Nup88 expression by Western-immunoblotting to test data obtained by IHC.RESULTS: Specific Nup88 expression was found in chronic HCV hepatitis and unspecific chronic hepatitis, whereas no or very weak Nup88 expression was detected in normal liver. The Nup88 expression was markedly reduced or missing in mild chronic HBV infection and inversely correlated with HBcAg expression. Irrespective of the HBV- or HCV-status, increasing Nup88 expression was observed in cirrhosis and dysplastic nodules, and Nup88 was highly expressed in hepatocellular carcinomas. The intensity of Nup88 expression significantly increased during carcinogenesis (P < 0.0001) and correlated with dedifferentiation (P < 0.0001). Interestingly, Nup88 protein expression was significantly downregulated in HBV-positive HepG2.2.15 (P < 0.002) and HB611 (P < 0.001) cell lines as compared to HBV-negative HepG2 cells. CONCLUSION: Based on our immunohistochemical data, HBV and HCV are unlikely to influence the expression of Nup88 in cirrhotic and neoplastic liver tissue, but point to an interaction of HBV with the nuclear pore in chronic hepatitis. The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 3 | Metabolism of different PCBs congeners in plant cell cultures显示文摘 | Wilken A Bock C Bokern M | 1995 | Environmental Toxicology and Chemistry1995，14，12： | 1 |
| 4 | Temperature-dependent oxygen extract ion from the ventilatory current and thecosts of ventilation in the cephalopod Sepia officinalis 显示文摘 | Melzner F Bock C Portner H O | 2006 | J Comp Physiol B: Biochem Syst Environ Physiol2006，176，7： | 1 |
| 5 | Ce- rebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI 显示文摘 | Bock N A Paiva F F Nascimento G C | 2008 | Brain research2008，1198，： | 1 |
| 6 | Metabolic differences between primary and recurrent human brain tumors:a ^1H - NMR spectroscopic investigation 显示文摘 | Lehnhardt FG Bock C Rohn G | 2005 | NMR Biomed2005，18，6： | 1 |
| 7 | Temperature-dependent oxygen extraction from the ventilatory current and the costs of ventilation in the cephalopod Sepia officinalis 显示文摘 | MELZNER F BOCK C PORTNER H O | 2006 | Journal of Comparative Physiology B : Biochemical Systemic and Environmental Physiology2006，176，7： | 1 |
| 8 | Dissociation of cognitive and emotional empathy in adolescents with autism spectrum disorders显示文摘 | Poustka L Rehm A Holtmann M Bock M Bohmert C Dziobek I | 2010 | Kindheit Und Entwicklung2010，19，： | 1 |
| 9 | Coordinate regulation of hu-man drug-metabolizing enzymes,and conjugatetransporters by the Ah receptor,pregnane X recep-tor and constitutive androstane receptor显示文摘 | Khle C Bock KW | 2009 | Bio-chem Pharmacol2009，77，4： | 1 |
| 10 | Carbohydrate structuraldetermination by NMR spectroscopy : modern methods andlimitations显示文摘 | Duus J Gotfredsen C H Bock K | 2000 | Chem Rev2000，100，45： | 1 |
| 11 | Effects of thyrotropin-and corticotropin-releasing hormone on blood pressure and plasma catecholamines in the anesthetized rat显示文摘 | Schulz C Christodulopulu E Bock A | 1994 | Neuropsychobiol1994，30，4： | 1 |
| 12 | Pathogenesis of pre-diabetes,mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and/or impaired glucose tolerance显示文摘 | Bock G Dalla C Campionim | | 0，，11： | 1 |
| 13 | The mammalian aryl hydrocarbon ( Ah ) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver显示文摘 | Bock KW Kohle C | 2009 | Biol Chem2009，390，12： | 1 |
| 14 | Molecular farming for new drugs and vaccines-Current perspectives on the production of pharmaceuticals in transgenic plants显示文摘 | Ma J K C Barros E Bock R | 2005 | EMBO Rep2005，6，7： | 1 |
| 15 | Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA显示文摘 | KLEIN C BOCK C T WEDEMEYER H | 2003 | Gastroenterology2003，125，： | 1 |
| 16 | Human papillomavirus-the moet significant risk determinant of cervical intraepithelial neoplasia显示文摘 | KJAER S K BRULE A J C BOCK J E | 1996 | Int J Cancer1996，65，： | 1 |
| 17 | Global DNA dem-ethylation during mouse erythropoiesis in vivo 显示文摘 | Shearstone JR Pop R Bock C | 2011 | Sci-ence2011，334，： | 1 |
| 18 | BiQ Analyzer:visualization and quality control for DNA methylation data from bisulfite sequencing显示文摘 | Bock C Reither S Mikeska T | | 0，，21： | 1 |
| 19 | Pathogenesis of pre - diabetes : mechanisms of fasting and postprandial hyperglycemia in People with impaired fasting glucose and/or impaired glucose tolerance 显示文摘 | BOCK G DALLA M C CAMPIONI M | 2006 | Diabetes2006，55，12： | 1 |
| 20 | Evaluation of cardiac STATus CK-MB/myoglobin device for rapidly ruling out acute myocardial infarction显示文摘 | Brogan GX Jr Bock J L MeCuskey C F | 1997 | Clin Lab Med1997，17，： | 1 |
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