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| 1 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 2 | Induction of apoptosis in human blood T cells by 7,8-dihydroneopterin:the difference between healthy controls and patients with systemic lupus erythematosus 显示文摘 | Wirleitner B Obermoser G Bock G | 2003 | Clin Immunol2003，107，3： | 2 |
| 3 | Activation of PDGF receptor alpha in vascular smooth muscle cells by mechanical stress 显示文摘 | Hu Y Bock G Wick G Xu Q | 1998 | FASEB J1998，12，12： | 1 |
| 4 | Behavioral intention formation in knowledge sharing:Examining the roles of extrinsic motivators,social-psychological forces,and organizational chmate显示文摘 | Bock G W Zmud R W Kim Y G Lee J N | | 0，，01： | 1 |
| 5 | Ce- rebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI 显示文摘 | Bock N A Paiva F F Nascimento G C | 2008 | Brain research2008，1198，： | 1 |
| 6 | Metabolic differences between primary and recurrent human brain tumors:a ^1H - NMR spectroscopic investigation 显示文摘 | Lehnhardt FG Bock C Rohn G | 2005 | NMR Biomed2005，18，6： | 1 |
| 7 | Organization and structure of the Methanococcus transcriptional unit homologous to the Escherichia coli 'Spectinomycin Operon' 显示文摘 | Auer J Spicker G Bock A | 1989 | J Mol Biol1989，209，1： | 1 |
| 8 | Break the Myths of Rewards:An Exploratory Study of Attitudes about Knowledge Sharing显示文摘 | BOCK G W KIM Y-G | 2002 | Information Resources Management Journal2002，15，2： | 1 |
| 9 | Behavioral In tention Formation in Knowledge Sharing: Exami ning the Roles of Extrinsic Motlvatiors, Social-Psy chological Forces, and Organizational Climate 显示文摘 | BOCK G ZMUD R KIM Y | 2005 | MIS Quarterly2005，29，1： | 1 |
| 10 | The potential for probiotics to prevent bacterial vaginosis and preterm labor显示文摘 | Reid G Bocking A | 2003 | Am J Obstet Gynecol2003，189，4： | 1 |
| 11 | Behavioral intention formation in knowledge sharing ex- amining the roles of extrinsic motivators, social - psychological forces and organizational climate 显示文摘 | BOCK G W | 2005 | MIS Quarterly2005，29，1： | 1 |
| 12 | Pathogenesis of pre-diabetes,mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and/or impaired glucose tolerance显示文摘 | Bock G Dalla C Campionim | | 0，，11： | 1 |
| 13 | Behavioral intention formation in knowledge sharing: Examining the roles of extrinsic motivators, social - psychological forces, and organizational climate 显示文摘 | Bock G W Zmud R W Kim Y G | 2005 | M1S Quarterly2005，29，1： | 1 |
| 14 | Behavioral intention formation inknowledge sharing: Examining the roles of extrinsic motivators,social-psychological forces 显示文摘 | Bock G W Robert W Z | 2005 | MIS Quarterly2005，29，1： | 1 |
| 15 | Validation of the 4B5 rabbit monoclonal antibody in determining HER-2/neu status in breast cancer显示文摘 | van der Vegt B de Bock G H Bart J | 2009 | Mod Pathol2009，22，7： | 1 |
| 16 | Pathogenesis of pre - diabetes : mechanisms of fasting and postprandial hyperglycemia in People with impaired fasting glucose and/or impaired glucose tolerance 显示文摘 | BOCK G DALLA M C CAMPIONI M | 2006 | Diabetes2006，55，12： | 1 |
| 17 | Breaking the Myths of Rewards: An Exploratory Study of Attitudes about Knowledge Sharing显示文摘 | Bock G W Kim Y G | 2002 | Information Resources Management Journal2002，，15： | 1 |
| 18 | Behav- ioral intention formation in knowledge sharing:Exam- ining the roles of extrinsic motivators, social-psycho- logical forces, and organizational climate 显示文摘 | Bock G W Zmud R W Kim Y G Lee J N | 2005 | MIS Quarterly2005，29，1： | 1 |
| 19 | The Business Model in Practice and Its Implications for Entrepreneumhip Research 显示文摘 | George G Bock A | 2011 | Entrepreneurship Theory and Practice2011，，1： | 1 |
| 20 | Quality of life of patients with keloid and hypertrophic scarring 显示文摘 | Bock O Schmid-Ott G Malewski P | 2006 | Arch Dermatol Res2006，297，10： | 1 |
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