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| 1 | 中国居民膳食结构与营养状况变迁追踪显示文摘 | 翟凤英 王惠君 杜树发 何宇纳 王志宏 葛可佑 BM Popkin | 2006 | 医学研究杂志2006，35，4： | 45 |
| 2 | 植物修复技术与农业生物环境工程显示文摘介绍了植物修复技术的概念、内涵、研究方法等,探讨了植物修复技术的优缺点和控制因素,指出农业生物环境工程手段的引进将有可能大幅度提高植物修复污染土壤的相对效率。 | 唐世荣 Wilk.,BM | 1999 | 农业工程学报1999，15，2： | 46 |
| 3 | Screening and analysis of the multiple absorbed bioactive components and metabolites of Dangguibuxue decoction by the metabolic fingerprinting technique and liquid chromatography/diode-array detection mass spectrometry显示文摘 | Wang, P Liang, YZ Zhou, N Chen, BM Yi, LZ Yu, Y Yi, ZB | 2007 | 中国生物学文摘2007，21，11： | 31 |
| 4 | 共焦显微镜鉴别诊断真菌性角膜炎的实验研究显示文摘目的 研究利用眼科用共焦显微镜鉴别诊断不同真菌性角膜炎的可行性。方法18只新西兰白兔均分为3组,右眼分别接种白色念珠菌、烟曲霉菌和腐皮镰刀菌。接种时,去除角膜中央区5mm直径的上皮,滴新鲜培养的1×107个细胞/ml的白色念珠菌悬浮液,或涂上新鲜培养的烟曲霉菌或腐皮镰刀菌孢子,盖上软性接触镜,行睑裂缝合。在角膜感染后的第5,10和15天时,行共焦显微镜检查、真菌涂片检查和病理切片检查。结果 感染早期(1~5天)炎症反应明显,中期(5~10天)炎症逐渐减轻,10~15天角膜形成疤痕而自愈。烟曲霉菌和腐皮镰刀菌的病程较迁延,反应较白色念珠菌重。共焦显微镜下,感染的白色念珠菌早期主要呈现芽孢状,成高亮度结构,以后发展成具有大量分支的树枝状结构,再发展成链状结构。感染10天后未见任何真菌结构。烟曲霉菌的菌丝在早期则呈较白色念珠菌菌丝粗但分支相对较少的明亮的树枝状结构。中期以后其分支减少并变长,它在角膜组织中保留的时间较白色念珠菌长。在感染早期,腐皮镰刀菌则表现为蚯蚓状结构,以后发展为分支很少的粗短树枝状结构,其分支在3种真菌中最少但直径最粗。真菌涂片和组织学检查的结果与共焦显微镜检查相符。结论 | 李绍伟 Gebhardt BM 史伟云 Beuerman RW Kaufman SC Kaufman HE 谢立信 | 2001 | 眼科研究2001，19，5： | 13 |
| 5 | 兔角膜组织细胞培养的技术改进显示文摘 | 谢立信 Gebh.,BM | 1990 | 中华眼科杂志1990，26，4： | 10 |
| 6 | Economic burden of Parkinson's disease in a developing country: A retrospective cost analysis in Shanghai, China显示文摘 | Wang G Cheng Q Zheng R Tan YY Sun XK Zhou HY Ye XL Wang Y Wang Z Sun BM Chen SD | 2006 | 中国生物学文摘2006，20，8： | 10 |
| 7 | A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity显示文摘AIM: To investigate H+, K+-ATPase inhibition, anti-H pylori , antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii; SRPP). METHODS: SRPP, with known sugar composition [rhamnose: arabinose: xylose: galactose in the ratio of 16:50:2:32 (w/w), with 141 mg/g of uronic acid] was examined for anti-ulcer potency in vivo against swim/ ethanol stress-induction in animal models. Ulcer index, antioxidant/antioxidant enzymes, H+, K+-ATPase and gastric mucin levels were determined to assess the anti- ulcer potency. Anti-H pylori activity was also determined by viable colony count and electron microscopic studies. RESULTS: SRPP, containing phenolics at 0.12 g GAE/g, prevented stress-induced gastric ulcers in animal models by 80%-85%. Down regulation of gastric mucin 2-3 fold, antioxidant/antioxidant enzymes and upregulation of 3 fold of H+, K+-ATPase in ulcerous animals were normalized upon treatment with SRPP. Histopathological analysis revealed protection to the disrupted gastric mucosal layer and epithelial glands. SRPP also inhibited H+, K+-ATPase in vitro, at an IC50 of 77 μg/mL as opposed to that of 19.3 μg/mL of Lansoprazole and H pylori growth at Minimum Inhibitory Concentration (MIC) of 150 μg/mL. In addition, free radical scavenging (IC50-40 μg/mL) and reducing power (3200 U/g) activities were also observed. CONCLUSION: SRPP, with defined sugar composition and phenolics, exhibited multi-potent free radical scavenging, antioxidant, anti-H pylori, inhibition of H+, K+-ATPase and gastric mucosal protective activities. In addition, SRPP is non-toxic as opposed to other known anti-ulcer drugs, and therefore may be employed as a potential alternative for ulcer management. | BM Srikanta MN Siddaraju Shylaja M Dharmesh | 2007 | World Journal of Gastroenterology2007，13，39： | 6 |
| 8 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 9 | 美国1988-2008期间高血压的发生情况、认识水平、治疗和控制显示文摘 | 张玲玉 叶鹏 Egan BM Zhao Y Axon RN | 2010 | 中华高血压杂志2010，18，9： | 6 |
| 10 | Escherichia coli tetracycline efflux determinants in relation to tetracycline residues in chicken显示文摘Objective:To screen for Escherichia coli(E.coli)resistant to tetracycline,followed by identification of tet efflux genes by polymerase chain reaction(PCR).In addition,detection of tetracycline residues in chicken livers and kidneys were conducted using high performance liquid chromatography-tandem quadrupole mass spectrometry(HPLC-MS-MS).Methods:Strains of E.coli were isolated from samples of chicken colon and screened for tetracycline resistance.Tetracycline genes conferring resistance(Tc^r)were detected by polymerase chain reaction(PCR).Most of the isolates were resistant to tetracycline(97.9%).Results:PCR analysis indicated that Tc^r E.coli R-plasmids contained tet(A),tet(B)and a combination of both efflux genes.None of the isolates contained other efflux tet genes tet(C,D,E and Y).High performance liquid chromatography-tandem quadrupole mass spectrometry(HPLC-MS-MS),a sensitive technique,was used to detect residues of chlortetracycline(CTC),oxytetracyeline(OTC),doxveycline(DC)in chicken livers and kidneys.The samples containing tetracycline residues were at 0.13-0.65pg/μL levels.Conclusions:Tetracycline and other antibiotics are commonly used in the poultry and meat production industry for prevention of microbial infections.Multiple antibiotic resistant bacteria in Oman have increased to alarming levels,threatening public health,domestic and may have adverse effect on environment. | Al-Bahry SN Al-Mashani BM Al-Ansari AS Elshafie AE Mahmoud IY | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 4 |
| 11 | 人角膜细胞对单纯...显示文摘 | 谢立信 Gebh.,BM | 1991 | 中华眼科杂志1991，27，4： | 4 |
| 12 | 基于社区的突发心源性猝死风险预测评分显示文摘尽管在美国,心源性猝死是导致死亡的主要原因,但大多数心源性猝死的死亡者在死亡前并未被确定为处于危险中。研究者试图建立和验证基于人群的心源性猝死的风险评分。方法:社区动脉粥样硬化风险(atherosclerosis risk in communities,ARIC)研究记录了基线年龄45~64岁男性和女性的临床指标,分析中包括了11 335名白人和3780名非洲裔受试者。受试者随访时间〉10年,心源性猝死由医师确定。 | 刘青 叶鹏 Bogle BM Ning H Goldberger JJ Mehrotra S Lloyd-Jones DM | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 13 | 长链非编码RNAPACER通过阻止抑制性的NF-κB复合物促进COX-2表达显示文摘长链非编码RNA(LncRNA)是一类长度大于200 bp,不编码蛋白的一类RNA,其参与调控多种生理过程,包括细胞分化、细胞周期、细胞迁移等,最主要的功能是调节基因的表达。环加氧酶2(cyclo-oxygenase 2,COX-2)是一种催化花生四烯酸生成前列腺素的酶,其能被细胞因子、炎症信号等诱导表达,在发热、疼痛、炎症、肿瘤等一些生理病理过程中发挥着重要的作用。鉴于COX-2能上调炎症信号,促进肿瘤的发生发展,本文作者对LncRNA介导的COX-2转录调控作了细致探讨。 | 赵锴 张迁 Krawczyk M Emerson BM | 2015 | 中国肿瘤生物治疗杂志2015，22，2： | 3 |
| 14 | Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver显示文摘AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat liver.METHODS After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by intravenousroute.At different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and immunohistochemistry.RESULTS The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the liver.CONCLUSION G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver. | Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 15 | 饮食性缺铜、缺锌对小鼠细胞因子产生的影响显示文摘3周龄小鼠饲用6周缺铜饮食后,出现胸腺萎缩、肝脏肿大以及明显的缺铜指征,包括血清Cp活性、肝Cu含量、CCO和Cu,Zn-SOD活性明显下降。缺钢小鼠产生的TNF-α、IL-1和IL-6水平明显低于正常组小鼠。小鼠饲予7周缺锌饮食后,出现明显脱毛,虽然肝Zn含量降低不明显,但TNF-α、IL-1和IL-6活性明显降低,说明上述细胞因子是小鼠缺锌的敏感指征之一。本文结果显示正常Cu、Zn水平对TNF-α、IL-1和IL-6产生的重要性,并提示这些细胞因子的改变可能是缺铜、缺锌引起的免疫功能损害的细胞、分子学机理之一。 | 金虹 Ha.,BM | 1996 | 上海免疫学杂志1996，16，2： | 3 |
| 16 | 心血管健康研究中血压轨迹与死亡率、心血管病事件和心力衰竭的关系显示文摘老年人的一般血压轨迹尚未明确,其与临床结局的关系也尚不确定。方法:本研究采用层次聚类分析法来确定心血管健康研究中4067参与者从0~7年重复测量血压值的血压轨迹。然后采用Cox比例风险回归模型评估每种血压轨迹聚类与全因死亡率、 | Smitson CC Scherzer R Shlipak MG Psaty BM Newman AB Sarnak MJ Odden MC Peralta CA 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 3 |
| 17 | Which Research Is Needed to Support Clinical Decision-Making on Integrative Medicine?——Can Comparative Effectiveness Research Close the Gap?显示文摘在关于互补、综合的药的临床的研究,尽管有终端用户的需要的不完全的理解,专家和科学家经常追求了一个研究议程。因而,以前的临床的试用的多数主要估计了干预的功效。欠缺的数据在他们的有效性上是可得到的。由产生比较最好的好处和伤害的证据支持决定制造者的比较有效性研究(CER ) 诺言在乎选择。这条证据,比证据可推广的更多由传统的使随机化的控制审判(RCT ) 产生了,更好被适合通知真实世界的照顾决定。CER 上的一个重音支持证据底的发展为临床并且政策决策。而在互补、综合的药的大多数区域比较有效性上的数据是少见的,可得到的针灸研究已经贡献 CER 证据。这篇论文将介绍 CER 并且为未来研究做建议。 | Claudia M.Witt 黄文静 Lixing Lao Berman BM | 2012 | Chinese Journal of Integrative Medicine2012，18，10： | 2 |
| 18 | IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation显示文摘 | Armitage RJ Macduff BM Eisenman J | 1995 | J Immunol1995，154，2： | 2 |
| 19 | Study on incisional implantation of tumor cells by carbon dioxide pneumoperitoneum in gastric cancer of a murine model显示文摘 | Wang H Zheng MH Zhang HB Zhu J He JR Lu AG Ji YB Zhang MJ Jiang Y Yu BM Li HW | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 20 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
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