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| 1 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 2 | Early therapy for latent tuberculosis infection 显示文摘 | ZIV E DALEY C L BLOWER S M | 2001 | American Journal of Epidemiology2001，153，： | 1 |
| 3 | Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners显示文摘 | BLOWER T R SALMOND G P C LUISI B | 2011 | Current Opinion in Slructural Biology2011，21，1： | 1 |
| 4 | The intrinsic transmission dynamics of tuberculosis epidemics 显示文摘 | BLOWER S M MCLEAN A R PORCO T C | 1995 | Nature Medicine1995，，1： | 1 |
| 5 | A Tale of Two Futures: HIV and Antiretroviral Therapy in San Francisco 显示文摘 | BLOWER S M GERSHENGORN H B GRANT R M | 2000 | Science2000，287，5453： | 1 |
| 6 | Modeling the emergence of the'hot zone':tuberculosis and the amplification dynamics of drug resistance显示文摘 | Chou T | 2004 | Nature Medicine2004，10，10： | 1 |
| 7 | Designing HIV Vaccination Potieies: Subtypes and Cross-Immunity 显示文摘 | PORCO T C BLOWER S M | 1998 | Interfaces1998，28，3： | 1 |
| 8 | Expression of a magainin-type antimicrobial gene (MS1-99) in tomato enhances resistance to bac- terial speck disease显示文摘 | Alan AR Blowers A Earle ED | 2004 | Plant Cell Rep2004，22，3： | 1 |
| 9 | Copper radionu- clides and radiopharmaceuticals in nuclear medi- cine显示文摘 | Blower PJ Lewis JS Zweit J | 1996 | Nucl Med Biol1996，23，： | 1 |
| 10 | The effect of antioxidants on bleomyem treatment in vitro and in vivo genotoxicity assays显示文摘 | Anderson D Basaran N Blowers SD | 1995 | Mutat Res1995，329，1： | 1 |
| 11 | Salmonella Typhimurium Infection in Duck Eggs as a Cause of Human Food Poisoning显示文摘 | BLAXLAND J D BLOWERS A J | 1951 | Vet Rec1951，63，4： | 1 |
| 12 | 5-hydroxytryptamine Type-3 receptor antagonists for chemotherapy-induced and radiotherapyinduced nausea and emesis:can we safely reduce the dose of administered agents? 显示文摘 | Aapro M Blower P | 2005 | Cancer2005，104，1： | 1 |
| 13 | Can influenza epidemics be prevented by voluntary vaccination?显示文摘 | VARDAVAS R BREBAN R BLOWER S | 2007 | PLoS Computational Biology2007，3，5： | 1 |
| 14 | Flicker phenomenon in human erythrocytes显示文摘 | Blowers R Clarkson EM Maizels M | | 0，，2： | 1 |
| 15 | Managing adverse events in the use of bevacizumab and chemotherapy显示文摘 | Blowers E Hall K | 2009 | Nurs2009，18，6： | 1 |
| 16 | The phage abortive infection system, ToxiN, functions as a protein-RNA toxin- antitoxin pair显示文摘 | FINERAN P C BLOWER T R FOULDS I J | 2009 | Proceedings of the National Academy of Sciences of the United States of America2009，106，3： | 1 |
| 17 | Modeling the emergence of the 'hot zones': tuberculosis and the amplii'ication dynamics of drug resistanee显示文摘 | Blower SM Chou T | 2004 | Nat Med2004，10，10： | 1 |
| 18 | Political Modernisation and the Environmental Question:the case for strategic planning显示文摘 | | 2002 | Local Government Studies2002，28，2： | 1 |
| 19 | MicroRNAs modulate the chemosensitivity of tumor cells显示文摘 | Blower PE Chung JH Verducci JS | 2008 | Mol Cancer Ther2008，7，1： | 1 |
| 20 | MicroRNAs modulate the chemosensitivity of tumor cells显示文摘 | Blower PE Chung JH Verducci JS | 2008 | Mol Can- cer Ther2008，7，1： | 1 |
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