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| 1 | 上皮细胞K^+通道的生理学意义与临床应用:跨上皮细胞转运的驱动力生成和K^+循环(英文)显示文摘K^+通道在上皮细胞内以极化的方式表达,形成一个庞大的膜蛋白家族。出于对主要依赖Na^+-K^+-ATPase而维持的细胞内跨膜K^+梯度的考虑,K^+通道在跨上皮细胞转运中的主要作用为:膜电位生成和K^+循环。本文以肾近端小管和胃壁上皮细胞转运为例简要阐述了K^+通道的作用。在这两个组织中,K^+通道活性限速跨上皮细胞转运,调节细胞体积。近年来,药理学工具和转基因动物的实验证实了对K^+通道的原先认知,并将研究深入到分子水平。K^+通道的分子结构挑战高亲和力药物分子的设计,及其多组织同时表达的两个典型特征阻碍了高活性、组织特异性小分子治疗的进展。然而,抑制K^+通道能阻断胃酸分泌等病理生理机制的深入研究,促进K^+通道药物用于胃病治疗和作为肾脏转运抑制剂用于肾脏相关疾病治疗。 | BLEICH Markus SHAN Qi-Xian | 2007 | 生理学报2007，59，4： | 2 |
| 2 | Influence of gas density and pressure on nicroparticles produced with the ASES process 显示文摘 | Bleich J Kleinebudde P Miiller BW | 1994 | International Journal of Pharmaceutics1994，106，： | 1 |
| 3 | Band-pass specific contributions of multiple generators to auditory 40 Hz steady state potentials 显示文摘 | Pratt H Mittelman N Bleich N | 2002 | Ear Hear2002，23，1： | 1 |
| 4 | Homocysteine and dementia显示文摘 | Kessler H Bleich S Falkai P | 2003 | Fortschr Neurol Psychiatr2003，71，3： | 1 |
| 5 | Perceived risk of amputation,emotion and foot self-care among adults with type 2 diabetes显示文摘 | Scollan-Koliopoulos M Walker EA Bleich D | 2010 | Diabetes Educ2010，36，3： | 1 |
| 6 | Homocysteine,alcoholism and its molecular networks显示文摘 | Bleich S Hillemacher T | 2009 | Pharmacopsychiatry2009，42，1： | 1 |
| 7 | Tissue sodium concentration in human brain tumors as measured with ^23Na MR imaging显示文摘 | Ouwerkerk R Bleich K B Gillen J S | 2003 | Radiology2003，227，2： | 1 |
| 8 | Isolated celiac and superior mesenteric artery dissection identified with MDCT: imaging findings and clinical course显示文摘 | Verde F Bleich KB Oshmyansky A | 2012 | J Comput Assist Tomogr2012，36，： | 1 |
| 9 | Nuclear magnetic resonance conformational studies of the chemotactic tripeptide formyl-L-methionyl-L-leucyl-L-phenylalanine: a small 13 sheet 显示文摘 | Becker EL Bleich HE Day AR | 1979 | Biochemistry1979，18，21： | 1 |
| 10 | How does Satisfaction with the Health-care System Relate to Patient Experience? 显示文摘 | Bleich S N Ozaltinb E Murray C J L | 2009 | Bull World Health Organ2009，87，： | 1 |
| 11 | Why is the developed world obese显示文摘 | Bleich S Cutler D Murray C | | 0，，： | 1 |
| 12 | Inhibition of Rho-kinase stimulates nitric oxide-independent vasorelaxation显示文摘 | Lohn M Steioff K Bleich M | 2005 | Eur J Pharmacol2005，507，13： | 1 |
| 13 | Clozapine in the treatment of mania显示文摘 | DEGNER D BLEICH S MULLER P | 2000 | J Neuropsychiatry Clin Neurosci2000，12，2： | 1 |
| 14 | Lack of association between hippoccmpal volume redultion and first- onsetalcohol withdrawal seizure a volumetric MRI study 显示文摘 | BLEICH S SPERLING W DEGNER D | 2003 | Alcohol Alcoholism2003，38，1： | 1 |
| 15 | Evidence of increased homocysteine levels in alcoholism:the Franconian Alcoholism Research Studies (FARS)显示文摘 | Bleich S Carl M Bayerlein K | 2005 | Alcohol Clin Exp Res2005，29，3： | 1 |
| 16 | Dynamic elastoplastic analysis of structures显示文摘 | BARON M L BLEICH H H | 1961 | Journal of Engineering Mechanics Division ASCE1961，77，1： | 1 |
| 17 | Stability of periodic orbits controlled by time-delay feedback显示文摘 | BLEICH M E SOCLAR J E S | 1996 | Phys Lett A1996，210，： | 1 |
| 18 | Inhibition of Rho-kinase stimulates nitric oxide-independent vasorelaxation 显示文摘 | Lhn M Steioff K Bleich M | 2005 | Eur J Pharmacol2005，507，： | 1 |
| 19 | Homocysteine and risk of open-angle glaucoma显示文摘 | Bleich S Junemann A yon Ahsen N | 2002 | J Neural Transm(Vienna)2002，109，12： | 1 |
| 20 | Impairment of homocysteine in tear fluid of patient with pseudoexfoliation glaucoma显示文摘 | Roedl JB Bleich S Reulbach U | 2007 | J Glau- coma2007，16，2： | 1 |
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