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| 1 | Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis显示文摘Acute pancreatitis(AP) is an inflammatory disease characterized by acute inflammation and necrosis of the pancreatic parenchyma. AP is often associated with organ failure, sepsis, and high mortality. The pathogenesis of AP is still not well understood. In recent years several papers have highlighted the cellular and molecular events of acute pancreatitis. Pancreatitis is initiated by activation of digestive enzymes within the acinar cells that are involved in autodigestion of the gland, followed by a massive infiltration of neutrophils and macrophages and release of inflammatory mediators, responsible for the local and systemic inflammatory response. The hallmark of AP is parenchymal cell necrosis that represents the cause of the high morbidity and mortality, so that new potential therapeutic approaches are indispensable for the treatment of patients at high risk of complications. However, not all factors that determine the onset and course of the disease have been explained. Aim of this article is to review the role of mitogen-activated protein kinases in pathogenesis of acute pancreatitis. | Natasha Irrera Alessandra Bitto Monica Interdonato Francesco Squadrito Domenica Altavilla | 2014 | World Journal of Gastroenterology2014，20，44： | 2 |
| 2 | Simvastatin attenuates the development of pulmonary and cutaneous fibrosis in a murine model of systemic sclerosis 显示文摘 | Bagnato G Bitto A Pizzino G | 2013 | Rheumatology (Oxford)2013，52，8： | 1 |
| 3 | Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice:a comparison study with methylprednisolone显示文摘 | Messina S Bitto A Aquennouz M | 2009 | Exp Neurol2009，220，2： | 1 |
| 4 | Effects of genistein aglyconein osteoporotic, ovarlectomize rats : a comparison with alendronate,raloxifene and oestradiol显示文摘 | Bitto A Burnett BP Polito F | 2008 | B J Pharmacol2008，155，6： | 1 |
| 5 | Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome显示文摘 | Bitto A Altavilla D Bonaiuto A | 2009 | Endocrinol2009，200，3： | 1 |
| 6 | PEAQ-The ITU Stan- dard for Objective Measurement of Perceived Audio Qu- ality显示文摘 | Thiede T Treurniet W C Bitto R | 2000 | Journal of the Audio Engineering Society2000，48，1： | 1 |
| 7 | Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds 显示文摘 | GALEANO M ALTAVILLA D BITTO A | 2006 | Crit Care Med2006，34，4： | 1 |
| 8 | DC-SIGN as a receptor for phleboviruses 显示文摘 | Lozach PY Kfihbacher A Meier R Mancini R Bitto D Bouloy M Helenius A | 2011 | Cell Host Microbe2011，10，1： | 1 |
| 9 | Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome显示文摘 | Bitto A Altavilla D Bonaiuto A | 2009 | J Endocrinol2009，200，3： | 1 |
| 10 | Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome显示文摘 | Bitto A Altavilla D Bonaiuto A | 2009 | J Endocrinol2009，200，3： | 1 |
| 11 | Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes显示文摘 | Bitto A Minutoli L Altavilla D | 2008 | Pharmacol Res2008，57，2： | 1 |
| 12 | Cyclic limonene dicarbonate as a new monomer for non-isoeyanate oligo- and polyurethanes (NIPU) based upon terpenes 显示文摘 | BAHR M BITTO A MDLHAUPT R | 2012 | Green Chemistry2012，14，5： | 1 |
| 13 | Cyclic limonene dicarbonate as a new monomer for non-isocyanate oligo- and polyurethanes (NIPU) based upon terpenes 显示文摘 | BAHR M BITTO A MULHAUPT R | 2012 | Green Chemistry2012，14，5： | 1 |
| 14 | Protective effect of genis-tein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methyl-prednisolone in rats显示文摘 | Bitto A Polito F Burnett B | | 0，，03： | 1 |
| 15 | Simvastatin attenuates the development of pulmonary and cutaneous fibrosis in a murine model of systemic sclerosis显示文摘 | Bagnato G Bitto A Pizzino G | 2013 | Rheumatology (Oxford)2013，52，8： | 1 |
| 16 | Genistein in the metabolic sy nd rome:results of a randomized cli nical t r ial显示文摘 | Squadrito F Marini H Bitto A | 2013 | J Cli n Endocrinol Metab2013，98，8： | 1 |
| 17 | Genistein and endothelial function in postmenopausal women with metabolic syndrome显示文摘 | Irace C Marini H Bitto A | 2013 | Eur J Clin Invest2013，43，10： | 1 |
| 18 | Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats 显示文摘 | Francesca Polito Herbert Marini Alessandra Bitto | 2012 | British Journal of Pharmacology2012，165，4： | 1 |
| 19 | The effect of PDRN, an adeno- sine receptor A2A agonist, on the healing of chronic diabetic foot ul- cers: results of a clinical trial显示文摘 | Squadrito F Bitto A Altavilla D | 2014 | The Journal of clinical endocrinology and metabolism2014，99，5： | 1 |
| 20 | Melanocortin MC recep- tor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia显示文摘 | Spaccapelo L Bitto A Galantucci M | 2011 | Ear Pha- macology2011，670，23： | 1 |
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