5篇
您的检索式：作者名="Bird Nigel"
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| 1 | Natural history of hepatic metastases from colorectal cancer-pathobiological pathways with clinical significance显示文摘Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process.This process starts with a series of mutations in colonic epithelial cells,continues with their detachment from the large intestine,dissemination through the blood and/or lymphatic circulation,attachment to the hepatic sinusoids and interactions with the sinusoidal cells,such as sinusoidal endothelial cells,Kupffer cells,stellate cells and pit cells.The metastatic sequence terminates with colorectal cancer cell invasion,adaptation and colonisation of the hepatic parenchyma.All these events,termed the colorectal cancer invasion-metastasis cascade,include multiple molecular pathways,intercellular interactions and expression of a plethora of chemokines and growth factors,and adhesion molecules,such as the selectins,the integrins or the cadherins,as well as enzymes including matrix metalloproteinases.This review aims to present recent advances that provide insights into these cell-biological events and emphasizes those that may be amenable to therapeutic targeting. | Konstantinos A Paschos Ali W Majeed Nigel C Bird | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 2 | On the mechanical behavior of the human biliary system显示文摘This paper reviews the progress made in understanding the mechanical behaviour of the biliary system. Gallstones and diseases of the biliary tract affect more than 10% of the adult population. The complications of gallstones, i.e. acute pancreatitis and obstructive jandice, can be lethal, and patients with acalculous gallbladder pain often pose diagnostic difficulties and undergo repeated ultrasound scans and oral cholecystograms. Moreover, surgery to remove the gallbladder in these patients, in an attempt to relieve the symptoms, gives variable results. Extensive research has been carried out to understand the physiological and pathological functions of the biliary system, but the mechanism of the pathogenesis of gallstones and pain production still remain poorly understood. It is believed that the mechanical factors play an essential role in the mechanisms of the gallstone formation and biliary diseases. However, despite the extensive literature in clinical studies, only limited work has been carried out to study the biliary system from the mechanical point of view. In this paper, we discuss the state of art knowledge of the fluid dynamics of bile flow in the biliary tract, the solid mechanics of the gallbladder and bile ducts, recent mathematical and numerical modelling of the system, and finally the future challenges in the area. | Xiaoyu Luo Wenguang Li Nigel Bird Swee Boon Chin NA Hill Alan G Johnson | 2007 | World Journal of Gastroenterology2007，13，9： | 9 |
| 3 | Generalizing the fractal model of soil structure:The pore - solid fractal approach显示文摘 | Edith Perrier Nigel Bird Michel Rieu | 1999 | Geoderma1999，88，： | 1 |
| 4 | Generalizing the fractal model of soil structure: the pore-solid fractal approach显示文摘 | Perrier Edith Bird Nigel Rieu Michel | 1999 | Geoderma1999，88，34： | 1 |
| 5 | Generalizing the fractal model of soil structure: the poresolid fractal approach显示文摘 | Edith Perrier Nigel Bird Michel Rieu | 1999 | Geoderma1999，88，34： | 1 |
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