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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Determination of hexabromocyclododecanes in sediments from the Haihe River in China by an optimized HPLC–MS–MS method显示文摘Hexabromocyclododecanes(HBCDs),a new type of persistent organic pollutants widely used as brominated flame retardants,have attracted wide attention due to their increasing level and toxicity. A method based on high-performance liquid chromatography mass spectrometry(HPLC–MS–MS)in electrospray ionization mode has been developed by optimization of various parameters,which effectively improved the separation degree and responsive intensity of α-,β-and γ-HBCD isomers. The concentrations and distribution profiles of three HBCD isomers were investigated in sediments from the Haihe River in China.It was observed that the concentrations of HBCDs varied in the range of 0.4–58.82 ng/g,showing a decreasing trend along the flow direction,possibly due to attenuation and biodegradation along the flow direction of the Haihe River. The distribution profile of α-,β-,γ-HBCD was 7.91%–88.6%,0–91.47%,and 0.62%–42.83%,respectively. Interestingly,α-HBCD dominated in most sample sites. This was different from the distribution profile in commercial industrial products,which might be attributed to the inter-transformation and different degradation rates of the three HBCD isomers. The potential ecological risk of HBCDs in sediment was characterized under the two-tiered procedure of the European Medicines Evaluation Agency for environmental risk assessment. Although the HBCDs in the selected section of the Haihe River presented 'no risk' in the sediment compartment,its risk in sediment cannot be neglected since sediment is one of the important sinks and reservoirs of pollutants. | Yanhui Zhao Qianqian Li Xue Miao Xinchen Huang Binke Li Guijin Su Minghui Zheng | 2017 | Journal of Environmental Sciences2017，29，5： | 5 |
| 3 | Frequency-specific abnormalities in regional homogeneity among children with attention deficit hyperactivity disorder: a resting-state f MRI study显示文摘Although many functional magnetic resonance imaging(f MRI) studies have investigated the neurophysiology of attention deficit hyperactivity disorder(ADHD),the existing studies have not yielded consistent findings.This may be related to the different properties of different frequency bands. To investigate the frequency-specific regional homogeneity(Re Ho) of spontaneous neural activities in ADHD, the current study used resting-state f MRI to explore the Re Ho properties of five frequency bands, slow-5(0.01–0.027 Hz), slow-4(0.027–0.073 Hz),slow-3(0.073–0.198 Hz), slow-2(0.198–0.25 Hz) and the extra-low frequency(0–0.01 Hz), in 30 drug-naive boys with ADHD and 30 healthy controls. Compared with controls, the ADHD group showed decreased Re Ho in the default mode network(DMN) including the medial prefrontal cortex and precuneus, middle frontal gyrus and angular gyrus. ADHD patients also showed increased Re Ho in the posterior cerebellum. Significant interactions between frequency band and group were observed predominantly in the dorsolateral prefrontal and parietal cortices, orbital frontal cortex, supplementary motor area,inferior occipital gyrus, thalamus and anterior cerebellum.In particular, we found that the between-group difference in the extra-low frequency band(0–0.01 Hz) seemed to be greater than that in the other frequency bands for most brain regions. The findings suggest that ADHD children display widespread abnormalities in regional brain activity,particularly in the DMN and attention network, and these abnormalities show frequency specificity. | Xiaoyan Yu Binke Yuan Qingjiu Cao Li An Peng Wang Alasdair Vance Timothy J.Silk Yufeng Zang Yufeng Wang Li Sun | 2016 | Science Bulletin2016，61，9： | 5 |
| 4 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 5 | Grain oriented growth and properties of ultra-high temperature CaBi_2Nb_2O_9 piezoelectric ceramics显示文摘CaBi2Nb2O9 (CBNO) ceramics was prepared at 1050℃ using regular flake-like CBNO powders as the precursor, and synthe-sized by the molten salts synthesis method. The tropism degree and microstructure of the ceramics were analyzed, and the die-lectric, ferroelectric and piezoelectric properties were characterized. Compared with conventional methods, the properties of CBNO ceramics by the new preparation method were found to be better. As the sinter temperature decreases, the grain growth becomes regular with textured features. The polarization process becomes easy to be realized at room temperature. Moreover, the dielectric loss decreases and the piezoelectric constant increases significantly. | TIAN XiaoXia QU ShaoBo WANG BinKe ZHANG WuSen ZHAO JianFeng | 2011 | Science China Chemistry2011，54，10： | 2 |
| 6 | Emulsions stabilised solely by colloidal particles显示文摘 | Aveyard R Binks B P Clint J H | 2003 | Colloid Interface Sci2003，，： | 1 |
| 7 | Rheological behavior of water-in-oil emulsions stabilized by hydrophobic bentonite particles显示文摘 | Bernard P Binks John H Chnt Catherine P Whitby | 2005 | Langmuir2005，21，21： | 1 |
| 8 | Influence of particle wettability on the type and stabilityof surfactant-free emulsions 显示文摘 | Binks B P Lumsdon S O | 2000 | Langmuir2000，16，23： | 1 |
| 9 | Preparation of particle - stabilized oil in water emulsions with the micrechannel emulsification method 显示文摘 | XU Q Y NAKAJIMA M BINKS B P | 2005 | Colloid Surface A2005，262，： | 1 |
| 10 | Genetic and QTL analyses of yield and a set of physiological traits in pepper 显示文摘 | Alimi N A Bink M Dieleman J A | 2013 | Euphytica2013，190，2： | 1 |
| 11 | Picketing emulsions stabilized by mono- disperse latex particles:effects of particle size显示文摘 | BINKS B P LUMSDON S O | 2001 | Langrnuir2001，17，15： | 1 |
| 12 | Today Coal Preparation Toolbox显示文摘 | Bink K Schimmouer | 1996 | Coal Age1996，，9： | 1 |
| 13 | Catastrophie Phase Inversion of Water- in-Oil Emulsions Stabilized by tIydrophobic Siliea显示文摘 | Binks B P Lumsdon S O | | Langmuir0，16，6： | 1 |
| 14 | Emulsions stabilized solely by colloidal particles 显示文摘 | AVEYARD R BINKS B P CLINT J H | 2003 | Adv Colloid Interface Sci2003，，2： | 1 |
| 15 | Influence of particle wettability on the type and stability of surfactant-free emulsions显示文摘 | Binks B P Lurnsdon S O | 2000 | Langmuir2000，16，23： | 1 |
| 16 | Emulsions stabilised solely by colloidal particles 显示文摘 | AVEYARD R BINKS B P CLINT J H | 2003 | Adv Colloid Interface Sci2003，，： | 1 |
| 17 | Aspects of aqueous foam stability in the presence of hydrocarbon oils and solid particles显示文摘 | Aveyard R Binks B P Fletcher P D I | 1994 | Adv Colloid Interf Sci1994，48，： | 1 |
| 18 | A plate tectonic setting for Mesozoic rifts of West and Central Africa显示文摘 | Binks R M Fairhead J D | | 0，，： | 1 |
| 19 | Emulsions stabilised solely by colloidal particles显示文摘 | AVEYARD R BINKS B P CLINT J H | 2003 | Advances in Colloid and Interface Science2003，，100102： | 1 |
| 20 | Eflect of electro- tyte in silicone oil-in-water emulsions stabilised by turned silica particles显示文摘 | Horozov T S Binks B P Gottschalk-Gaudig T | 2007 | Phys Chem Chem Phys2007，48，9： | 1 |
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