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| 1 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 2 | Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases显示文摘Alzheimer's and Parkinson's diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer's disease, α-synuclein and synphilin-1 for Parkinson's disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer's and Parkinson's diseases. | aline freyssin guylène page bernard fauconneau agnès rioux bilan | 2018 | Neural Regeneration Research2018，13，6： | 3 |
| 3 | Adaptation strategy for sea level rise in vulnerable areasalong China's coast显示文摘It can be seen from the calculation that the vulnerable area along China’s coast in which the elevation is less than 5 m, is 143 900 km2, accounting for about 11. 3% of the total area of the 11 coastal provinces, municipalities and autonomous regions. These areas are threatened to varying extent by sea level rise. According to prediction, the relative sea level rise (including global sea level rise caused by climate change and local relative as level rise caused by vertical crust movement and ground subsidence) along China’s coast will be 4~16 cm by the year 2030 with the optimum estimated value of 6~14cm. It will be 9~26 cm by the year 2050 with the optimum estimated value of 12-23 cm. And it will be 31-74 cm by the year 2100 with the optimum estimated value of 47~65 cm. The calcuation result shows that the percentage of the cost for up-grading (heightening and consolidating) sea dykes/walls in adaptation strategy in the losses of submerged areas varies from area to area: 6. 9% in the Zhujiang (Pearl) River Deta, 1. 3% ~24. 6% in the Changjiang (Yangtze) River Delta, and 0. 9%~2. 0% in the Huanghe River Delta. | Du Bilan, Zhang Jinwen (China Institute of Marine Affairs, State Oceanic Administration, Beijing 100860, China National Marine Data and Information Service, Tianjin 300171, China) | 2000 | Acta Oceanologica Sinica2000，19，4： | 3 |
| 4 | Adsorption and reduction of palladium (Pd^(2+)) by Bacillus licheniformis R08显示文摘Preliminary study on the mechanism of Pd2+ biosorption by resting cells of Bacillus licheniformis R08 biomass has been carried out by means of chemical kinetics and AAS, TEM, XRD and FTIR methods. The results showed that at 30°C and pH 3.5, when dry R08 biomass powder (800 mg/L) was mixed with Pd2+ (100 mg/L) for 45 min, the rate constant k of biosorption of Pd2+ attained a maximum of 5.97×10-2 min-1 and the half life period of the reaction reached 12 min. The part of Pd2+ adsorbed by R08 biomass was reduced to elemental, cell-bound Pd0 at the same condition. The cell wall of R08 biomass was the primary location for accumulating Pd2+, and aldoses, i. e. hy-drolysate of a part of polysaccharides on the peptidoglycan layer in the acidic medium, serving as the electron donor, in situ reduced the Pd2+ to Pd0. | LIN Zhongyu, ZHOU Chaohui, WU Jianming, CHENG Hu, LIU Bilan, Nl Zimian, ZHOU Jianzhang & FU JinkunState Key Laboratory for Physical Chemistry of Solid Surface, Department of Chemistry, Xiamen University, Xiamen 361005, China | 2002 | Chinese Science Bulletin2002，47，15： | 2 |
| 5 | Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity显示文摘Triple-negative breast cancer(TNBC)is the most challenging subtype of breast cancer.Various endeavor has been made to explore the molecular biology basis of TNBC.Herein,we reported a novel function of factor Kinectin 1(KTN1)as a carcinogenic promoter in TNBC.KTN1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer,and TNBC patients with high KTN1 expression have poor prognosis.In functional studies,knockdown of KTN1 inhibited the proliferation and invasiveness of TNBC both in vitro and in vivo,while overexpression of KTN1 promoted cancer cell proliferation and invasiveness.RNA-seq analysis revealed that the interaction of cytokine-cytokine receptor,particularly CXCL8 gene,was upregulated by KTN1,which was supported by the further experiments.CXCL8 depletion inhibited the tumorigenesis and progression of TNBC.Additionally,rescue experiments validated that KTN1-mediated cell growth acceleration in TNBC was dependent on CXCL8 both in vitro and in vivo.Furthermore,it was found that KTN1 enhanced the phosphorylation of NF-κB/p65 protein at Ser536 site,and specifically bound to NF-κB/p65 protein in the nucleus and cytoplasm of cells.Moreover,the transcription of CXCL8 gene was directly upregulated by the complex of KTN1 and NF-κB/p65 protein.Taken together,our results elucidated a novel mechanism of KTN1 gene in TNBC tumorigenesis and progression.KTN1 may be a potential molecular target for the development of TNBC treatment. | Lin Gao Shanze Chen Malin Hong Wenbin Zhou Bilan Wang Junying Qiu Jinquan Xia Pan Zhao Li Fu Jigang Wang Yong Dai Ni Xie Qinhe Yang Hsien-Da Huang Xiang Gao Chang Zou | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 6 | Natural stilbenes effects in animal models of Alzheimer’s disease显示文摘Alzheimer’s disease is one of the most frequent neurodegenerative diseases.This pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive impairments.Drugs currently proposed to treat this pathology do not prevent neurodegenerative processes and are mainly symptomatic therapies.However,stilbenes presenting multiple pharmacological effects could be good potential therapeutic candidates.The aim of this review is to gather the more significant papers among the broad literature on this topic,concerning the beneficial effects of stilbenes (resveratrol derivatives) in animal models of Alzheimer’s disease.Indeed,numerous studies focus on cellular models,but an in vivo approach remains of primary importance since in animals (mice or rats,generally),bioavailability and metabolism are taken into account,which is not the case in in vitro studies.Furthermore,examination of memory ability is feasible in animal models,which strengthens the relevance of a compound with a view to future therapy in humans.This paper is addressed to any researcher who needs to study untested natural stilbenes or who wants to experiment the most effective natural stilbenes in largest animals or in humans.This review shows that resveratrol,the reference polyphenol,is largely studied and seems to have interesting properties on amyloid plaques,and cognitive impairment.However,some resveratrol derivatives such as gnetin C,trans-piceid,or astringin have never been tested on animals.Furthermore,pterostilbene is of particular interest,by its improvement of cognitive disorders and its neuroprotective role.It could be relevant to evaluate this molecule in clinical trials. | Aline Freyssin Guylène Page Bernard Fauconneau Agnès Rioux Bilan | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 7 | Liver X receptor stimu- lates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells 显示文摘 | Delvecchio CJ Bilan P Radford K | 2007 | Mol Endocri- nol2007，21，6： | 1 |
| 8 | Contraction-related stimuli reg- ulate GLUT4 traffic in C2C 12-GLUT4myc skeletal muscle cells显示文摘 | Niu W Bilan P J Ishikura S | 2010 | Am J Physiol Endocrinol Metab2010，298，5： | 1 |
| 9 | Contraction-related stimuli regu- late GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells显示文摘 | Niu W Bilan PJ Ishikura S | 2010 | Am J Physiol Endocrinol Metab2010，298，5： | 1 |
| 10 | Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4mye skeletal muscle cells显示文摘 | Niu W Bilan PJ Ishikura S | 2010 | Am J Physiol Endocrinol Metab2010，298，5： | 1 |
| 11 | Isolation and Preliminary Characterization of a Highly Pyruvylated Galactan Sulfate from Codium yezoense (Bryopsidales, Chlorophyta) 显示文摘 | Bilan M B Vinogradova E V Shashkov A S | 2006 | Botaniea Marina2006，49，3： | 1 |
| 12 | A singleamino acid substitution in serpes simplex virus type 1 VP16 inhibits binding to the virionhost shutoff protein and isincompatible with virus growth显示文摘 | knez J Bilan P T Capone J P | 2003 | J Virol2003，77，： | 1 |
| 13 | Structure of a highly pyruvylated galactan sulfate from the Pacific green alga Codium yezoense (Bryopsidales,Chlorophyta)显示文摘 | Bilan M I Vinogradova E V Shashkov A S | 2007 | Carbohydrate Research2007，342，34： | 1 |
| 14 | Rab8A and Rabl3are activated by insulin and regulate GLUT4 transloca-tion in muscle cells 显示文摘 | SUNY BILAN P J LIU Z | 2010 | Proceedings of the NationalAcademy of Sciences of the United States of Ameri-ca2010，107，19： | 1 |
| 15 | Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells 显示文摘 | Moyers iS Bilan PJ Reynet C | 1996 | Biol Chem1996，271，23： | 1 |
| 16 | A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle显示文摘 | Schertzer JD Antonescu CN Bilan PJ | | 0，，04： | 1 |
| 17 | Need for GLUT4 activation to reach maximum effect of Insulin-Mediated glucose uptake in brown adipocytes isolated from GLUT4 myc-Expressing Mice显示文摘 | KONRAD D BILAN PJ NAWAZ Z | 2002 | Diabetes2002，51，9： | 1 |
| 18 | The Rab GTPaseactivating protein AS160 integrates Akt,protein kinase C,and AMP-activated protein kinase signals regulating GLUT4 traffic显示文摘 | Thong FS Bilan PJ Klip A | 2007 | Diabetes2007，56，2： | 1 |
| 19 | Lateral thermal damage to rat abdominal wall after harmonic scalpel application显示文摘 | Perko Z Pogorelic Z Bilan K | 2006 | Surg Endosc2006，20，2： | 1 |
| 20 | Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells 显示文摘 | Niu W Bilan PJ Ishikura S | 2010 | Am J Physiol Endocrinol Metab2010，298，5： | 1 |
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