| 2 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
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