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| 1 | 独特性之后:法庭科学意见的演进显示文摘法庭科学正在发生巨变,尤其是对从事指纹、鞋印、刀痕、笔迹及诸如此类图形比对的鉴定专家们而言。司法鉴定人正在以新的方式得出结论,并在改变他们报告和证言中所使用的语言。本文解释了这些变化,及其给律师和法官们带来的挑战。 | William C. Thompson Joelle Vuille Franco Taroni Alex Biedermann 汪诸豪(译) | 2018 | 证据科学2018，26，4： | 11 |
| 2 | Identification of CD13,CD107a,and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-de-pendent upregulation显示文摘Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FcεRI). These include antibod- ies against CD164 (WS-80160, clone N6B6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880). The activation patterns followed either the “CD203c-like” or “CD63-like” activation profile. The CD203c profile is characterized by a rapid and significant upregulation (of CD13, CD164, and CD203c), reaching maximum levels after 5- 15 min of stimulation. The phosphoinositide-3-kinase (PI3K)-specific inhibitor wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FcεRI-independent upregulation within 1-2 min. In the CD63 profile, maximum upregulation (of CD63 and CD107a) was detected only after 20-40 min, and upregulation by TPA reached maximum levels after 60 min. In summary, our data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. Based on time kinetics of upregulation, we hypothesize that molecules of the “CD203c group” and the “CD63 group” are linked to two different mechanisms of basophil activation. | Florian HENNERSDORF Stefan FLORIAN Andreas JAKOB Katharina BAUMGRTNER Karoline SONNECK Alfred NORDHEIM Tilo BIEDERMANN Peter VALENT Hans-Jrg BüHRING | 2005 | Cell Research2005，15，5： | 9 |
| 3 | Use of thiopurines in inflammatory bowel disease显示文摘The use of thiopurines as immunosuppression for the treatment of refractory or chronic active inflammatory bowel disease is established for both Crohn's disease and ulcerative colitis.Nevertheless,many questions remain concerning the optimal treatment regimens of azathioprine,6-mercaptopurine and thioguanine.We will briefly summarize dose recommendations,indications for thiopurine therapy and side effects which are relevant in clinical practice.We discuss some currently debated topics,including the combination of azathioprine and allopurinol,switching of thiopurine therapy in case of side effects,the use of azathioprine in pregnancy,the infection risk using thiopurines and the evidence when to stop thiopurines.Excellent reviews have been published on the thiopurine metabolic pathway which will not be discussed here in detail. | Pascal Frei Luc Biedermann Ole Haagen Nielsen Gerhard Rogler | 2013 | World Journal of Gastroenterology2013，19，7： | 4 |
| 4 | Role of retinal glial cells in neurotransmitter uptake and metabolism显示文摘 | Andreas Bringmann Thomas Pannicke Bernd Biedermann Mike Francke Ianors Iandiev Jens Grosche Peter Wiedemann Jan Albrecht Andreas Reichenbach | 2008 | Neurochemistry International2008，，3： | 2 |
| 5 | Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy显示文摘 | Winkler DT Biedermann L Tolnay M | 2002 | Ann Neurol2002，51，6： | 1 |
| 6 | Yeast proteinase in beer 显示文摘 | Dreyer T Biedermann K Ottesn M | 1983 | Carlsberg Res Comnmn1983，48，3： | 1 |
| 7 | The prediction of failure of the stem in THR by measurement of early migration using EBRA-FCA 显示文摘 | Krismer M Biedermann R Stockl B | 1999 | J Bone Joint Surg Br1999，81，： | 1 |
| 8 | Body size and area-incidence relationships:is there a general pattern显示文摘 | Biedermann R | 2003 | Global Ecology and Biogeography2003，12，38： | 1 |
| 9 | Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium buffering 显示文摘 | Kofuji P Biedermann B Siddharthan V | 2002 | Glia2002，39，3： | 1 |
| 10 | Sustained T-bet expression confers polarized human TH2 cells with THl-like cytokine production and migratory capacities 显示文摘 | Lametschwandtner G Biedermann T Schwarzler C | 2004 | J Allergy Clha Immunol2004，113，5： | 1 |
| 11 | Clinical results using the trochanter stabilizing plate(TSP): the modular extension of the dynamic hip screw (DHS) for internal fixation of selected unstable intertrochanteric fracture显示文摘 | Babst R Renner N Biedermann M | 1998 | Orthop Trauma1998，12，6： | 1 |
| 12 | Loss of angiotensin II receptor expression in dopamine neurons in Parkinson inverted question marks disease correlates with pathological progression and is accompanied by increases in Nox4-and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation显示文摘 | Zawada W Mrak RE Biedermann J | 2015 | Acta Neuropathol Commun2015，3，： | 1 |
| 13 | In GC-MS, acrylamide from heated foods may be coeluted with 3-hydroxy propionitrile显示文摘 | Maurus Biedermann Koni Grob | 2008 | European Food Research and Technology2008，，3： | 1 |
| 14 | Use of dynamic magnetic resonance imaging to detect sacroiliitis in HLA-B27 positive and negative children with juvenile arthritides显示文摘 | Bollow M Biedermann T Kannenberg J | 2000 | J Rheumatol2000，27，10： | 1 |
| 15 | Satu- rated and Aromatic Mineral Oil Hydrocarbons from Paper- board Food Packaging: Estimation of Long-Term Migration from Contents in the Paperboard and Data on Boxes from the Market显示文摘 | LORENZINI R FISELIER K BIEDERMANN M | 2010 | Food Additives & Contaminants: Part A2010，27，12： | 1 |
| 16 | Odour control at biowaste composting facilities显示文摘 | Schlegelmilch M Streese J Biedermann W | 2005 | Waste Manage2005，25，9： | 1 |
| 17 | Diversity of Kir channelsubunit mRNA expressed by retinal glial cells of the guinea-pig 显示文摘 | Raap M Biedermann B Braun P | 2002 | Neuroreport2002，13，8： | 1 |
| 18 | Extracorporeal shock waves in the treatment of nonunions显示文摘 | Biedermann R Martin A Handle G | 2003 | J Trauma2003，54，5： | 1 |
| 19 | Complications and pa- tient satisfaction after periacetabular pelvic osteotomy显示文摘 | Biedermann R Donnan L Gabriel A | 2008 | Int Orthop2008，32，5： | 1 |
| 20 | Simulating progressive iteration, rework and change propagation to prioritise design tasks 显示文摘 | Maier J F Wynn D C Biedermann W | 2014 | Research in Engineering Design2014，25，4： | 1 |
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