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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | A new liquid chromatography/mass spectrometry method for 4-(methyl- nitrosamino) -1- (3-pyridyl) -1-butanol (NNAL) in urine 显示文摘 | Bhat S H Gelhaus S L Mesaros C | 2011 | Rapid Communications in Mass Spectrometry2011，25，1： | 1 |
| 3 | A simple general synthesis of 1-alkynyldiisop ropoxyboranes 显示文摘 | Brown H C Bhat N G Srebnik M | 1988 | Tetrahedron Letters1988，29，22： | 1 |
| 4 | The protein data bank显示文摘 | Berman H M Westbrook J Feng Z K Gilliland G Bhat T N Weissig H Shindyalov L N Bourne P E | | 0，，01： | 1 |
| 5 | Shear characteristics of soil -gravel mixtures 显示文摘 | Doddiah D Bhat H S Somasekhar P V | 1969 | Journal of the Indian National Society of Soil Mechanicsand Foundations Engineering1969，8，1： | 1 |
| 6 | Aromatase inhibitors from Broussonetia papyrifera 显示文摘 | Lee D Bhat K P L Fong H H S | 2001 | Journal of Natural Products2001，64，： | 1 |
| 7 | Preferential induction of cytochrome P4501A1 over cytochrome P4501B1 in human breast epithelial cells following exposure to quercetin显示文摘 | Mense S M Chhabra J Bhat H K | 2008 | J Steroid Biochem Mol Biol2008，110，12： | 1 |
| 8 | Microwave synthesis of electrode materials for lithium batteries 显示文摘 | BHAT M H CHAKILAVARTHY B P RAMAKRISHNAN P A LEVASSEUR RAO J | 2000 | Bulletin of Materials Science2000，23，6： | 1 |
| 9 | The Physics and Technology of Gallium Antimonide: An Emerging Optoelectronic Material显示文摘 | Dutta P S Bhat H L Vikram K | 1997 | J Appl Phys1997，81，： | 1 |
| 10 | Effects of sodium dodecyl sulphate and sonication treatment on physicochemical properties of starch显示文摘 | Chan H T Bhat R Karim A A | 2010 | Food Chemistry2010，120，： | 1 |
| 11 | Identification of failure modes in GFRP using PDVF sensors:ANN approach显示文摘 | H N Bar M R Bhat | 2004 | Composite Structures2004，65，： | 1 |
| 12 | Characterization of chemical vapor deposited HfN multilayer coatings on cemented carbide cutting tools显示文摘 | Staia M H Bhat DG Puchi-Cabrera ES | 2006 | Wear2006，261，5： | 1 |
| 13 | Safety and efficacy of low-fluence, high-repetition rate versus high-fluence, low- repetition rate 810-nm diode laser for permanent hair remov- al--a split-face comparison study 显示文摘 | Pal G S Bhat P S Mallya H | 2011 | J Cosmet Laser Ther2011，13，4： | 1 |
| 14 | Fetal ventricular mass determination on three-dimensional echocardiography: Studies in normal fetuses and validation experiments显示文摘 | Bhat A H Corbett V Carpenter N | 2004 | Cir- culation2004，110，9： | 1 |
| 15 | Review of CVD TiN coatings for wear resistant applications: deposition processes, properties and performance 显示文摘 | Rebenne H E Bhat D G | 1994 | Surface and Coating Technology1994，63，1： | 1 |
| 16 | Laparoscopicadrenalectomy is feasible for large adrenal masses >6 cm显示文摘 | Bhat H S Nair T B Sukumar S | 2007 | Asian] Surg2007，30，1： | 1 |
| 17 | Nickel induced crystallization of amorphous silicon thin films显示文摘 | JIN Z H BHAT G A YEUNG M | 1998 | J Appl Phys1998，84，1： | 1 |
| 18 | LC determination and pharmacokinetics of meloxicam显示文摘 | Shivaprakash Saroj H Bhat KM | 2002 | J Pharm Biomed Anal2002，28，5： | 1 |
| 19 | Potential of zeolite supported rhodium catalysts for the CO2 reforming of CH4显示文摘 | Sachtler W M H Bhat R N | 1997 | Appl Catal1997，150，2： | 1 |
| 20 | Targeting the ANGPT -TIE2 pathway in malignancy 显示文摘 | Huang H Bhat A Woodnutt G | 2010 | Nature Reviews Cancer2010，10，8： | 1 |
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