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| 1 | Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents. | Kyle Crassini Stephen P Mulligan O Giles Best | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 2 | 猪饲料调味剂:—印迹法提高采食量显示文摘 | Best,P 朱丽华 | 1992 | 国外畜牧科技1992，19，1： | 5 |
| 3 | Sediment-related growth limitation of Elodea nuttallii as indicated by a fertilization experiment显示文摘 | BEST E P WOLTMAN H JACOBS F H | 1996 | Fresh Water Biology1996，36，： | 1 |
| 4 | The impact of renal insufficiency on clinical outcomes in patients undergoing percutaneous coronary inter-ventions显示文摘 | Best P J Lennon R Ting H H | 2002 | Am Coll Cardiol2002，39，： | 1 |
| 5 | Bayesian measures of model complexity and fit (with discussion)显示文摘 | SPIEGELHALTER D J BEST N G CARLIN B P | 2002 | Journal of the Royal Statistical Society2002，64，： | 1 |
| 6 | Statistical bias correction of global simulated daily precipitation and temperature for the application of hydrological models显示文摘 | PIANI C WEEDON G P BEST M | 2010 | J Hydrol2010，395，34： | 1 |
| 7 | Crystallographic analysis of an 'anticalin'with tailored specificity for fluorescenin reveals high structural plasticity of the lipocalin loop region显示文摘 | INGO P K BESTE G SKERRA A | 2003 | Proteins:Struc Func and Cene2003，52，： | 1 |
| 8 | Geospatial Web services within a scientific workflow: predicting marine mammal habitats in a dynamic environment显示文摘 | BEST B D HALPIN P N FUJIOKA E | 2007 | Ecological Informaties2007，2，3： | 1 |
| 9 | An extended adaptive Kalman filter for real-time state estimation of vehicle handling dynamics 显示文摘 | Best M GordonT Dixon P | 2000 | Vehi- cle System Dynamics2000，34，1： | 1 |
| 10 | Three - dimensional sedimentary architecture of a large, mid - channel sand braid bar, Jamuna river, Bangladesh 显示文摘 | Best J L Ashworth P J Bristow C S | 2003 | Journal of Sedimentary Research2003，73，4： | 1 |
| 11 | The aquatic macrophytes of Lake Vechten: species composition, spatial distribution and production 显示文摘 | Best E P H | 1982 | Hydrobiologia1982，95，： | 1 |
| 12 | The impact of renal insuffi-ciency on clinical outcomes in patients undergoing percutaneouscoronary interventions显示文摘 | Best P J Lennon R Ting H H | 2002 | J Am Coll Cardiol2002，39，7： | 1 |
| 13 | Particulate emission reduction in small-scale biomass combustion plants by a condensing heat exchanger显示文摘 | de Best C J J M van Kemenade H P Brunner T | 2008 | Energy and Fuels2008，，22： | 1 |
| 14 | Bayesian measures of model complexity and fit (with discussion) 显示文摘 | Spiegelhalter D J Best N G Carlin B P and Van der Linde A | 2002 | Journal of the Royal Statistical Society (Series B)2002，64，4： | 1 |
| 15 | An extended adaptive Kalman filter for real-time state estimation of vehicle handling dy- namics 显示文摘 | BEST M C GORDON T J DIXON P J | 2000 | Vehicle System Dynamics2000，34，1： | 1 |
| 16 | Determination of COD using a sealed-tube method显示文摘 | Best D G Decassers K P | 1978 | Water Pollution Control1978，77，1： | 1 |
| 17 | Estimation of SPOT P-mode Point Spread FunCtion and Derivation of a DeConvolution Filter 显示文摘 | Forster B C Best P | 1994 | ISPRS Journal for RS and GIS1994，49，6： | 1 |
| 18 | Test of fit for the geometric distri- bution显示文摘 | Best D J P ayner J C W | | 0，，05： | 1 |
| 19 | Increasing prevalence of Helicobacter pylori infection with age:continuous risk of infection in adults rather than cohort effect显示文摘 | VELDHUYZENVAN ZANTEN S J POLLAK P T BEST L M | 1994 | J Infect Dis1994，169，2： | 1 |
| 20 | Macro-invertebrate communities associated with the macrophytes of Lake Vechten: structural and functional relationships显示文摘 | Dvoak J Best E P H | 1982 | Hydrobiologia1982，95，： | 1 |
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