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| 1 | Effect of serum γ-glutamyltranferase and albumin levels on the response to cardiac resynchronization therapy in the elderly显示文摘Background Several liver function tests have been identified as predictors of hospitalization for heart failure(HF) and death in patients with chronic HF. The relationship between serum γ-glutamyltranferase(GGT) and albumin(SA) levels with the response to cardiac resynchronization therapy(CRT) has not been reliably determined. The aim of the study was to evaluate the impact of liver function tests on the results of CRT in the elderly. Methods Baseline GGT and SA were assessed before CRT device implantation in the elderly(> 70-year-old) patients. The endpoints were:(1) CRT response defined as > 5% left ventricular ejection fraction improvement and no hospitalization for HF or cardiovascular death;(2) hospitalizations;and(3) mortality. Results Eighty of 138(58%) included patients were responders at nine months. Compared to responders, the SA levels were not significantly different(35.1 ± 5.4 vs. 33.6 ± 5.5 g/L, P = 0.103);but the GGT levels, higher(81.6 ± 69.3 vs. 54.7 ± 49.6 U/L, P = 0.013) in non-responders to CRT. GGT level was independently associated with non-response to CRT(P < 0.001, OR = 0.17;95% CI: 0.08–0.38, P < 0.001). GGT cut-off value ≥ 55 U/L was highly predictive of non-response [AUC = 0.65, 64% Sensitivity, 69% Specificity(95% CI: 0.56–0.74)]. GGT ≥ 55 U/L was also associated with higher risk of hospitalization for atrial fibrillation(AF)(95% vs. 83%, P = 0.024). Both SA and GGT had no impact on overall(P = 0.220, P = 0.723) mortality. Conclusions Higher level of GGT is an independent predictor of non-response to CRT in patients over age 70 years and is associated with higher risk of hospitalization for AF. Baseline serum levels of albumin and GGT and have no impact on mortality in elderly patients undergoing CRT. | Maciej Kubala Alexis Hermida Otilia Buiciuc Pierre-Marc Lallemand Geneviève Bertaina Frédéric Anselme Didier Klug Momar Diouf Jean-Sylvain Hermida | 2020 | Journal of Geriatric Cardiology2020，17，6： | 3 |
| 2 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 3 | K+ channelopeners prevent global ischemia- induced expression of C-fos,C-jun, heat shock prot ein, and amyloid beta -protein precur-sor genes and neuronal death in rat hippo -campus显示文摘 | Heurteaux C Bertaina V Widmann C | 1993 | ProcNail Acad Sci USA1993，90，94： | 1 |
| 4 | Performance of a multi-anode photomultiplier employing a weak electrostatic focusing system(Hamamatsu R8900 series)显示文摘 | Kawasaki Y Bertaina M E Sakaki N | 2006 | Nuclear Instruments and Methods in Physics Research2006，564，： | 1 |
| 5 | K + channel openers prevenl global ischemia-induced expression of c-los, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus显示文摘 | Heurteaux C Bertaina V Widmann C | 1993 | Proc Natl Acad Sci USA1993，90，20： | 1 |
| 6 | Human cytomegalovirus infection promotes rapid maturation ofNKcelis expressing activating killer Ig- like receptor in patients transplanted with NKG2C-/- umbilical cord blood 显示文摘 | Della Chiesa M Falco M Bertaina A | 2014 | J Immunol2014，192，4： | 1 |
| 7 | Clofarabine, cyclophosphamide and etoposide as single- course re-induction therapy for children with refractory/multiple re- lapsed acute lymphoblastie leukaemia显示文摘 | Loealelli F Testi AM Benlardo ME Rizzari C Bertaina A Merli P | 2009 | Br J Haematol2009，147，3： | 1 |
| 8 | HLA -haploiden- tical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders显示文摘 | BERTAINA A MERLI P RUTELLA S | 2014 | Blood2014，124，5： | 1 |
| 9 | Cord blood trans-plantation in children with haematological malignancies 显示文摘 | Bertaina A Bernardo ME Caniglia M | 2010 | BestPract Res Clin Haematol2010，23，2： | 1 |
| 10 | K + channel openers prevent global ischemia-induced expression of C-fos, C-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippo-campus显示文摘 | Heurtoaux C Bertaina V Lazdunski M | 1993 | Proc Natl Acad Sci USA1993，90，： | 1 |
| 11 | Experimental investi-gation over stimulated Raman scattering limitation on WDM transmission over various types of fiber infranstruc-tions显示文摘 | S Gauchard A Bertaina | 1999 | IEEE photon technology letter1999，1，： | 1 |
| 12 | Magnetic strong coupling in a spin-photon system and transition to classical regime 显示文摘 | Chiorescu I Groll N Bertaina S | 2010 | Phys Rev B2010，82，02： | 1 |
| 13 | K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid β-protein precursor genes and neuronal death in rat hippocampus显示文摘 | Bertaina V Widmann C | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 14 | K^+ channel opens prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein and amyloidal beta-protein precursor genes and neuronal death in rat hippocampus 显示文摘 | Heurteaux C Bertaina V Widmann C | 1993 | Proc Natl Acad Sci USA1993，90，： | 1 |
| 15 | Experimental investigation of stimulated Raman scattering limitation on WDM transmission over various types of fiber-infrastructure显示文摘 | Gauchard S Bertaina A | 1999 | IEEE Photon Technol Lett1999，11，： | 1 |
| 16 | Experimental investigation over stimulated Raman scattering limitation on WDM transmission over various types of fiber infranstructions显示文摘 | S Bigo S Gauchard A Bertaina | 1999 | IEEE photon technology letter1999，，1： | 1 |
| 17 | HLA-haploiden- tical stem cell transplantation after removal of ctl3+T and B cells in children with nonmalignant disorders 显示文摘 | BERTAINA A MERLI P RUTELLA S | 2014 | Blood2014，124，5： | 1 |
| 18 | K + channel o- peners prevent globalischemia - induced expression of c - fos, c -jun, heat shock protein, and amyloid 15 - protein precur- sor genes and neuronal death in rat hippocampus显示文摘 | Heurteaux C Bertaina V Widmann C | 1993 | ProcNatl Acad Sci USA1993，90，： | 1 |
| 19 | Mobilization of healthy donors with plerixa for affects the cellular composition of T cell receptor(TCR)-αβ/CD19-depleted hap loidentical stem cell grafts显示文摘 | Rutella S Filippini P Bertaina V | 2014 | J Transl Med2014，12，： | 1 |
| 20 | K+ channel openers prevent global ischemic-inducod expression of c-fos,c-jun,heat shock protein, and amyloid β-protein precursor genes and neuronal death in rat hippocampus显示文摘 | Honrteaux C Bertaina V Widmann C | 1993 | Proc Natl Acad Sci USA1993，90，20： | 1 |
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