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| 1 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 2 | Benzyl-penicillin ( Penicillin G) transformation in aqueous solution at low temperature under controlled laboratory conditions 显示文摘 | BERGHEIM M HELLAND T KALLENBORN R | 2010 | Chemosphere2010，81，11： | 1 |
| 3 | Solids management and removal for intensive land-based aquaculture production systems 显示文摘 | CRIPPS S J BERGHEIM A | 2000 | Aquacultural Engineering2000，22，1： | 1 |
| 4 | Critical role ofplasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis显示文摘 | Bergheim I Guo L Davis MA | 2006 | J Pharmacol Exp Ther2006，316，2： | 1 |
| 5 | Solids management and removal for intensive land-based aquaculture production systems 显示文摘 | CRIPPS S J BERGHEIM A | 2000 | Aquacultural Engineering2000，22，： | 1 |
| 6 | DNA methylation of alternativepromoters directs tissue specific expression of Epac2isoforms显示文摘 | HOIVIK E A WITSOE S L BERGHEIM I R | 2013 | PLoS One2013，8，67： | 1 |
| 7 | Bevacizumab therapy for POEMS syndrome显示文摘 | Straume O Bergheim J Ernst P | 2006 | Blood2006，107，12： | 1 |
| 8 | SJWD15012600002617显示文摘 | Giridhar Kanuri Ruth Ladurner Julia Skibovskaya Astrid Spruss Alfred K?nigsrainer Stephan C. Bischoff Ina Bergheim | 2015 | Liver Int2015，，2： | 1 |
| 9 | Towards a reduction of pol- lution from intensive aquaculture with reference to the farm- ing of salmonids in Norway 显示文摘 | SEYMOUR E A BERGHEIM A | 1991 | Aquaculture Engineering1991，02，10： | 1 |
| 10 | Solids management and removal for intensive land-based aquaculture production systems显示文摘 | Cripps Simon J Asbjφrn Bergheim | 2000 | Aquacultural Engineering2000，22，： | 1 |
| 11 | Bevacizumab therapy for POEMS syndrome 显示文摘 | Straume O Bergheim J Ernst P | 2006 | Blood2006，107，12： | 1 |
| 12 | Critical role of plasminogen activator inhibitor-1 in cholestatic Ever injury and fibrosis 显示文摘 | Bergheim I Guo L Davis MA | 2006 | J Pharmacol Exp Ther2006，316，2： | 1 |
| 13 | Solids management and removal for intensive land-based aquaculture production systems显示文摘 | CRIPPS S J BERGHEIM A | 2000 | Aquacultural Engineering2000，22，： | 1 |
| 14 | A system for the treatment of sludge from land-based fish-farms显示文摘 | Bergheim A Cripps S J Litved H | 1998 | Aquat Living Resour1998，11，： | 1 |
| 15 | Dietary fructo~ and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease显示文摘 | Spruss A Bergheim I | 2009 | JNutrBiochem2009，20，9： | 1 |
| 16 | Bevacizumab therapy for POEMS syndrome显示文摘 | Straume O Bergheim J Ernst P | 2006 | Blood2006，107，： | 1 |
| 17 | Metformin prevents alcohol-induced liver injury in the mouse:critical role of plasminogen activator inhibitor-1显示文摘 | Bergheim I Guo L Davis MA | 2006 | Gastroenterology2006，130，7： | 1 |
| 18 | Critical role of plasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis显示文摘 | Bergheim I Guo L Davis MA | 2006 | J Pharmacol Exp Ther2006，316，2： | 1 |
| 19 | Bevacizumab therapy for POEMS syndrome 显示文摘 | Straume O Bergheim J Ernst P | 2006 | Blood2006，107，12： | 1 |
| 20 | Dietary fructose and intestinal barrier: potentialrisk factor in the pathogenesis of nonalcoholic fatty liver disease 显示文摘 | Spruss A Bergheim I | 2009 | JNutr Biochem2009，20，9： | 1 |
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