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14篇 您的检索式：作者名="Beom L"

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		题名	作者	年代	出处	被引量
	1	Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD.	Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun	2015	World Journal of Gastroenterology2015，21，45：	9
	2	Finite Element Analysis and Design in Stainless Steel Sheet Forming and Its Experimental Comparison 显示文摘	Li P L Sang M H Beom S K	2001	Journal of Materials Processing Technology2001，110，1：	1
	3	A study on the frame work for survivability assessment system of damaged ships 显示文摘	Dongkon L Soon Sup Lee Beom Jin Park	2005	0eean Enigneeirng2005，32，1：	1
	4	Antioxidant effects of L-Camosine on liposomes and beef homegenates显示文摘	Beom J L Deloy G	1997	J Food Sei1997，5，：	1
	5	Antioxidant effects of Lcarnosine on liposomes and beef homogenates显示文摘	Beom J L Deloy G H	1997	Food Science1997，62，5：	1
	6	High cell density fed-batch cultivation of Escherichia coil using exponential feeding combined with pH-star显示文摘	BEOM S K SEUNG C L SANG Y L	2004	Bioprocess Bio-systems Engineering2004，26，：	1
	7	Antioxidant effects of carnosine on liposomes and beef homogenates显示文摘	Beom L Hendricks G	1997	Food Sci1997，62，：	1
	8	A study on the framework for survivability assessment system of damaged ships显示文摘	DONGKON L SOON S L BEOM J P	2005	Ocean Engineering2005，32，1：	1
	9	Therapeutic acid on experimental osteoarthritis of ovine temporomandibuiar joint 显示文摘	Chang H K Beom I L Jung H Y	2001	J Vet Med Sci2001，63，10：	1
	10	Drop Formation Via Break of a Liquid Bridge in an AC Electric Field 显示文摘	Beom S L	2006	Journal of Colloid and Interface Science2006，302，：	1
	11	Improved hierarchical search block matching algorithm by using multiple motion vector candidates 显示文摘	Beom R J	1997	Elec Lett1997，33，21：	1
	12	Antioxidant effects of carnosine on liposomes and beef homogenates显示文摘	BEOM J L HENDRICKS G	1997	Food Science1997，62，：	1
	13	Therapeutic acid on experimental osteoarthritis of ovine temporomandibularjoint显示文摘	Chang H K Beom I L Jung H Y	2001	J Vet Med Sci2001，63，10：	1
	14	Phytic acid protective effect against beef round muscle lipid peroxidation 显示文摘	BEOM J L DELOY G H	1995	Journal of Food Science1995，2，：	1

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