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您的检索式：作者名="Benjamin Lant"
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| 1 | Fluorescent Visualization of germline apoptosis in living caenorhabditiselegans显示文摘 | Benjamin Lant Wbrent Derry | 2014 | Cold Spring Harbor Laboratory Protocols2014，，4： | 1 |
| 2 | Antinociceptive effects of novel epibatidine analogs through activation of α4β2 nicotinic receptors显示文摘The study of α4β2 nicotinic receptors has provided new indications in the treatment of pain. Efforts have been made to explore new α4β2 nicotinic receptor agonists, including TC-2559, as antinociceptive drugs. In this study, we discovered a set of novel epibatidine analogs with strong binding affinities to the α4β2 nicotinic receptors. Among these compounds, C-159, C-163, and C-9515 attenuated formalin-induced nociceptive responses in mice; C-9515 caused the most potent analgesic effect, which was blocked by mecamylamine, a non-selective nicotinic receptor antagonist. Furthermore, C-9515 potently inhibited chronic constriction injury(CCI)-induced neuropathic pain in rats, which was sensitive to DHβE, a selective α4β2 subtype antagonist,indicating that its analgesic effect was mediated by the activation of the α4β2 nicotinic receptors. In conclusion, the epibatidine analog C-9515 was found to be a potent α4β2 nicotinic receptor agonist with potent analgesic function, which demonstrated potential for the further exploration of its druggability. | Weiwei Li Jingyi Cai Benjamin H Wang Lanting Huang Jing Fan Yun Wang | 2018 | Science China(Life Sciences)2018，61，6： | 0 |
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