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| 1 | E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome显示文摘瞄准:调查在颜色在转移的进程期间发生在 E-cadherin 表示的变化表面的癌症。方法:E-cadherin 表示被免疫组织化学检测,表示的二个索引是计算的它反映了表示和地点(膜和细胞质) 的水平。Univariate 并且多,变量幸存分析被用来作为两个的预言者估计这二个 E-cadherin 索引的价值没有疾病(DFS ) 并且疾病特定(决策支持系统) 幸存。结果:E-cadherin 膜索引(MI ) ,然而并非细胞质的索引(CI ) ,比他们的转移在原发性瘤是显著地更高的(P = 0.0001 ) 。而且,原发性瘤 MI 和 CI 在开发了随后的转移的病人之中是更高的(P = 0.022 并且 P = 0.007,分别地) 。有趣地,两个索引在与另外的解剖地点相比的肝转移是更高的(MI, P = 0.034 并且 CI, P = 0.022 ) 。原发性瘤的 CI 是 DFS 的一个重要预言者(P = 0.042, univariate 分析) ,与在 CI 和 DFS 之间的强壮的反的关联(P = 0.006,多变量分析) 。最后,原发性瘤的 MI 证明了是决策支持系统的一个重要独立预言者,与与更有利的结果被联系的更高的索引(P = 0.016 ) 。结论:在颜色的 E-cadherin 表示和分发的检查表面的肿瘤能在预言是极其珍贵的疾病复发。E-cadherin 的异常细胞质的表示能预言疾病复发为病人和临床医生显然是很重要的,并且显著地有关病人的治疗和管理影响决定的观察。 | Adam Elzagheid Annika lgars Riyad Bendardaf Hanan Lamlum Raija Ristamaki Yrjo Collan Kari Syrjanen Seppo Pyrhonen | 2006 | World Journal of Gastroenterology2006，12，27： | 17 |
| 2 | Bcl-2 expression significantly correlates with thymidylate synthase expression in colorectal cancer patients显示文摘AIM: To examine the expression of thymidylate synthase (TS) and oncoprotein Bcl-2 in advanced colorectal cancer (CRC) patients,and to determine their mutual relationship,association to therapeutic response and impact on disease outcome.METHODS: Tumor samples from 67 patients with CRC,who were treated at advanced stage with either irinotecan alone or in combination with 5-fluorouracil/ leucovorin,were analyzed for expression of TS and Bcl-2 using immunohistochemistry.RESULTS: A significant linear correlation between lower expression levels of Bcl-2 and lower levels of TS expression was found (P = 0.033).Patients with high levels of both TS and Bcl-2 expression had a significantly longer disease-free survival (DFS) (42.6 mo vs 5.4 mo,n = 25) than those with low TS/Bcl-2 index (P = 0.001).Tumors with low levels of both TS and Bcl-2 were associated with a longer survival with metastasis (WMS) interval in the whole patients group (n = 67,P = 0.035).TS/Bcl-2 index was not significantly related to disease-specific survival.CONCLUSION: The present data suggest that CRC patients with low TS/Bcl-2 demonstrate a significantly shorter DFS and longer WMS. | Riyad Bendardaf Raija Ristmaki Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，40： | 2 |
| 3 | Prognostic signifi- cance of matrix metalloproteinase-9 ( MMP-9 ) in stage II colorectal carcinoma 显示文摘 | Buhmeida A Bendardaf R Hilska M | 2009 | J Gastrointest Cancer2009，40，34： | 1 |
| 4 | PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage Ⅱ colorectal carcinoma显示文摘 | Buhmeida A Bendardaf R Hilska M | 2009 | Ann Oncol2009，20，7： | 1 |
| 5 | E - eadherin, CD44s and CD44v6correlate with tumour differentiation in eoloreetal cancer 显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | OncolRep2005，13，5： | 1 |
| 6 | VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival 显示文摘 | Bendardaf R Buhmeida A Hilska M | 2008 | Anticancer Res2008，28，6： | 1 |
| 7 | MMP-9 (gelatinase B) expression is associated with disease-free survival and disease-specific survival in colorectal cancer patients显示文摘 | Bendardaf R Buhmeida A Hilska M | 2010 | Cancer Invest2010，28，1： | 1 |
| 8 | PL4,2 (group Ⅱ A phospholipase A2 ) as a prognostic determinant in stage Ⅱ colorectal carcinoma 显示文摘 | Buhmeida A Bendardaf R Hilska M | 2009 | Ann Oncol2009，20，7： | 1 |
| 9 | E-cadherin, CD44S and CD44V6 correlate with tumor differentiation in colorectalcancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | OncolRep2005，13，5： | 1 |
| 10 | E-cadherin,CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | Oncol Rep2005，13，5： | 1 |
| 11 | E-cadherin,CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer显示文摘 | Bendardaf R Elzagheid A | 2005 | Oncol Rep2005，13，5： | 1 |
| 12 | M M P-9(gela-tinase B)expression is associated with disease-free sur-vival and disease-specific survival in colorectal cancer pa-tients显示文摘 | Bendardaf R Buhmeida A Hilska M | | 0，，1： | 1 |
| 13 | E - cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer 显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | Oncol- Rep2005，13，5： | 1 |
| 14 | E-cadherin, CD44S and CD44V6 correlate with tumor differentiation in colorectal cancer显示文摘 | BENDARDAF R ELZAGHEID A LAMLUM H | 2005 | Oncol Rep2005，13，5： | 1 |
| 15 | CD44 variant 6 espression predicts response to treatment in advanced colorectal cancer 显示文摘 | Bendardaf R Lamlum H Ristama KIR | 2004 | Cancer Oncol Rep2004，11，1： | 1 |
| 16 | Comparison of CD44 expression in primary tumors and metastases of colorectal cancer显示文摘 | Bendardaf R Algars A Elzagheid A | 2006 | Oncology Reports2006，16，4： | 1 |
| 17 | Comparison of CD44 expression in primary tumours and metastases of colorectal cancer显示文摘 | Bendardaf R A lgars A Elzagheid A | 2006 | Oncol Rep2006，16，4： | 1 |
| 18 | Ecadherin,CD44s and CD44v6 correlate with tumour differentiati on in colorectal cancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2009 | Oncol Rep2009，13，5： | 1 |
| 19 | E-cadherin, CD44s and CD44V6 correlate with tumourd ifferentiation in colorectal cancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | Oncol Reo2005，13，5： | 1 |
| 20 | Prognosticand predictive molecular markers in colorectal carcinoma 显示文摘 | BENDARDAF R LAMLUM H PYRHONEN S | 2004 | Anticancer Res2004，24，4： | 1 |
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